vaccine design
Genome-based vaccine design: the promise for malaria and other infectious diseases
... drug design and target selection (chemoge- nomics) has led to the identification of new classes of antimicrobial drugs (Bhattacharjee et ...genome-based vaccine design is well under way and showing ...
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In silico-based vaccine design against Ebola virus glycoprotein
... in vaccine design that the distribution of HLA varies according to the diverse ethnic groups and geographic regions around the ...the vaccine will be ...
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Effect of Plasmid DNA Vaccine Design and In Vivo Electroporation on the Resulting Vaccine-Specific Immune Responses in Rhesus Macaques
... pDNA vaccine designs carrying HIV env, gag, pol, nef, tat, and vif were tested for the ability to elicit HIV-1 antigen-specific CMI and humoral immune responses in rhesus ...candidate vaccine designs were ...
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Monoclonal Antibodies against Zika Virus: Therapeutics and Their Implications for Vaccine Design
... ZIKV vaccine design, FL MAbs should be ...mRNA vaccine candidate incorporates T76R, Q77E, W101R, and L107R mutations to destroy the ...mRNA vaccine can prevent ZIKV disease and be adapted to ...
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Particulate delivery systems in vaccine design
... rational vaccine design, which, in combination with a more traditional empirical approach in development should yield more effective and safer vaccines with more clearly defined function and ...for ...
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In Silico Epitope-Based Peptide Vaccine Design against Invasive Non Typhoidal Salmonella (iNTS) Through Immunoinformatic Approaches
... effective vaccine candidate is the first step of designing an effective ...vaccine. Vaccine refers to a pharmacological product that can provide the best cost-benefit ratio to fight against ...
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Poly and autoreactivity of HIV 1 bNAbs: implications for vaccine design
... HIV-1 vaccine design, and potential ways to access normally forbidden compartments of the antibody repertoire by modulating or circumventing tolerance ...
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Human antibody response to dengue virus: implications for dengue vaccine design
... DENV vaccine design Currently, there are no licensed dengue vaccine which are used ...Dengue vaccine research has been carried out for the past 70 years, beginning with the first isolation of ...
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Classification of self-assembling protein nanoparticle architectures for applications in vaccine design
... These results pave the way for the optimisation of SAPN morphologies for ap- plications in vaccine design. To generate an optimal humoral immune response, repetitive antigen display is a key determinant ...
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L1 and L2 gene polymorphisms in HPV 58 and HPV 33: implications for vaccine design and diagnosis
... Genital HPV subtypes are typically divided into two groups according to their presumed oncogenic potential. High-risk oncogenic HPV subtypes −16, −18, −58, −33, −52 and −45 are more common in Asia than elsewhere [5]. ...
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An Envelope-Modified Tetravalent Dengue Virus-Like-Particle Vaccine Has Implications for Flavivirus Vaccine Design
... available vaccine or specific therapeutic for DENV ...tetravalent vaccine, DENV1-4 VLPs elicited high levels of neutralization activity against all four serotypes ...VLP vaccine development, due to ...
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Characterization of Influenza H5N1 Nucleocapsid Protein for Potential Vaccine Design
... Avian influenza, subtype H5N1, causes occasional but serious infections in humans and efforts to produce vaccines against this strain continue. Current influenza vaccines are prophylactic and utilize the two major ...
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Enhancing vaccine design strategies : applications for protein science, proteomics and adjuvants
... To stimulate new collaborations and developments in vaccines, the British Council recently funded a workshop led by two organisations with complementary skills and objectives; Aston University in the UK, and Ho Chi Minh ...
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Combinatorial Approach to Hepadnavirus-Like Particle Vaccine Design
... Generation of a library of C-terminal modifications on WHcAg. Importantly, the expansion of the number of positions available for insertion of foreign epitopes was made possible by the generation of a library of ...
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Norovirus immunobiology and vaccine design
... trivalent vaccine that did not include the LV antigen was still able to induce BT50 values in mice that were roughly twice that necessary for blockade following a multivalent challenge that did include the LV ...
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Potential contribution of gut microbiota and systemic inflammation on HIV vaccine effectiveness and vaccine design
... mercialized vaccine response are linked with the levels of T-cell activation and translocation of bacterial products such as LPS into the systemic circulation [20] ...HIV vaccine specific IgA response [23] ...
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<p>Immunoinformatics and Vaccine Development: An Overview</p>
... Personalized vaccines stem from our understanding of how, within the human leukocyte antigen (HLA) sys- tem – also referred to as the major histocompatibility complex (MHC), the T cells are able to recognize peptides of ...
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Strategies for an HIV vaccine
... Finally, highly purified viral protein, produced through recombinant DNA technology, has been a highly effec- tive immunogen for preventing hepatitis B virus infec- tion in humans. Some years ago, this approach to HIV ...
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Design of an epitope-based peptide vaccine against spike protein of human coronavirus: an in silico approach
... 54. Agnihothram S, Gopal R, Yount BL, et al. Platform strategies for rapid response against emerging coronaviruses: MERS-CoV serologic and anti- genic relationships in vaccine design. J Infect Dis [serial ...
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Novel Concepts for HIV Vaccine Vector Design
... to vaccine design based on the systematic design of epitopes, the use of immunogenic adjuvants, and the selection of appropriate delivery ...on vaccine immunogenicity, safety, and ...HIV ...
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