Vaccine Efficacy
A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine
... of vaccine immunogenicity (anti-CSP antibody titres), decay in antibody titres, and the association between antibody titres and clinical ...predict vaccine efficacy in a range of scenarios. Results: ...
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A New Furunculosis Challenge Method for Evaluation of Vaccine Efficacy in Rainbow Trout
... Experimental infection of fish for vaccine efficacy studies is associated with several limitations. Administration of live bacteria with the purpose of causing disease in fish can be performed by ...
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Clinical trials: The mathematics of falling vaccine efficacy with rising disease incidence
... the efficacy of vaccines, as estimated from randomised controlled trials in different parts of the world, are commonplace in the literature ...lower vaccine efficacy when measured in settings where ...
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Measles Vaccine Efficacy in Children Previously Vaccinated at 12 Months of Age
... niore months of age. Vaccine efficacy for those vaccinated at 12 iiionths of age was notably l)etter than for those vacci- nated at younger ages but not different froni those vacci- nate[r] ...
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Real-time Investigation of Measles Epidemics with Estimate of Vaccine Efficacy
... the vaccine efficacy, three distinct study approaches have been ...the vaccine-induced immunity in a biologically well-defined ...tual vaccine-induced protection ...the efficacy using ...
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Exploiting dendritic cells to improve vaccine efficacy
... DCs via TLRs and TNF-Rs. One tolerance mechanism is exerted by DCs bearing the DEC-205 receptor in the lymph nodes. When antigen is targeted to these DCs in the absence of a maturation stimulus, interacting T cells ...
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Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria
... of vaccine efficacy than defining a clinical episode by a cut-off threshold and would partially eliminate the problem of differing sensi- tivities and specificities in each arm of the ...of vaccine ...
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Acellular pertussis vaccine efficacy: An updated systematic review and meta –analysis
... whole-cell vaccine which was developed in the 1940s ...acellular vaccine may be more efficient than whole-cell vaccine (5), although according to the technical adviso- ry group on ...
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Heterogeneity in malaria exposure and vaccine response: implications for the interpretation of vaccine efficacy trials
... Whilst these results are intuitively clear, it is often assumed that randomization will diminish or remove their effect. Clearly randomization should at the least ensure that characteristics such as individual-level ...
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Vaccine Efficacy of Seasonal Inactivated Influenza Vaccine Using in Chinese Children and Adolescent Under 18 Years of Age: A Meta-Analysis
... There were three published reviews on assessing the vaccine efficacy (VE) in health children [9-11]. These quantitative estimates were relatively similar, but their conclusions were inconsistent. One review ...
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Characterization of a Cynomolgus Macaque Model of Pneumonic Plague for Evaluation of Vaccine Efficacy
... rF1V efficacy studies described here were conducted to fur- ther develop the CM model for use in testing the efficacy of rF1V according to the requirements of the FDA Animal ...one vaccine dose, our ...
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Systematic review of dengue vaccine efficacy
... greater efficacy of the vac- cine for children 9 years of age and low efficacy for chil- dren between 2 and 5 years of age, which can be explained by the greater seropositivity as children grow and acquire ...
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Comparison of hepatitis B vaccine efficacy in Japanese students: a retrospective study
... According to the guideline [9, 10], the HB vaccine is administered as a three-dose series with a 0-, 1-, and 6-month schedule. Nursing students have their first vaccination in May, and medical students have their ...
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Comparison of the Whole-Genome Sequence of an Oka Varicella Vaccine from China with Other Oka Vaccine Strains Reveals Sites Putatively Critical for Vaccine Efficacy
... varicella vaccine became available in 1998. Currently, the vaccine is produced by four domestic companies, namely, Changchun BCHT Biotechnology (also known as Baike), Changchun Keygen Biological Products, ...
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Genomic Analysis Reveals Pre- and Postchallenge Differences in a Rhesus Macaque AIDS Vaccine Trial: Insights into Mechanisms of Vaccine Efficacy
... Group II animals showed a distinct upregulation of pro- cesses implicating activated macrophages. For the protein- boosted vaccine recipients, the differential functional analysis of Fig. 6 indicates a very ...
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A Neonatal Murine Model of Coxsackievirus A6 Infection for Evaluation of Antiviral and Vaccine Efficacy
... Several animal models have been developed for the evaluation of EVA71 and CVA16 vaccine candidates (38–43). Because of the upsurge in epidemic HFMD attributable to CVA6 in the last 5 years, there is an urgent need ...
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Vaccine Efficacy of Inactivated, Chimeric Hemagglutinin H9/H5N2 Avian Influenza Virus and Its Suitability for the Marker Vaccine Strategy
... H9/H5N2 vaccine, they showed moderate body weight loss until 5 dpi ( ⬎ 10%) following homologous mouse-adapted virus infections ...a vaccine is able to provide protection from mortality, immunized animals ...
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Analysis of HLA A*02 Association with Vaccine Efficacy in the RV144 HIV-1 Vaccine Trial
... strain rgp120 included in the boost (16). Several recent findings seem to suggest that the V2 antibodies that correlated inversely with risk may have been cross-reactive: (i) the IgG V1/V2 CoR reported in RV144 by Haynes ...
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Vaccine efficacy and T helper cell differentiation change with aging
... the efficacy of influenza vaccination declines with aging [40, 41] but the exact mechanisms responsible for this remain ...the efficacy of an influenza vaccine consisting of the highly conserved ...
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Toward a better understanding of the relationship between influenza vaccine efficacy against specific and non-specific endpoints and vaccine efficacy against influenza infection
... moderate vaccine effectiveness against influenza infection (only 35% of influenza cases prevented), given the maximum possible value of ...influenza vaccine effectiveness, while for other endpoints it may ...
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