Vaccine Vector
Use of a novel enhanced DNA vaccine vector for preclinical virus vaccine investigation
... DNA vaccine vector containing a porcine circovirus (PCV-1) enhancer element that significantly increases recombinant antigen expression and immunogenicity and allows for dose ...
11
A Vesicular Stomatitis Virus-Based Hepatitis B Virus Vaccine Vector Provides Protection against Challenge in a Single Dose
... HBV vaccine in humans may be advantageous in situations where single-dose immunization eliminates logistical difficulties associated with the current HBV vaccine ...HBV vaccine series do not develop ...
10
The Nucleoprotein Is Required for Lymphocytic Choriomeningitis Virus-Based Vaccine Vector Immunogenicity
... In summary, the following conclusions can be drawn. (i) Transgenes under 3= UTR control can be expressed in the absence of de novo NP synthesis, albeit at very low levels. (ii) Still, in the absence of NP synthesis in ...
5
Stimulation of Human Monocytes with the Gram-Positive Vaccine Vector Streptococcus gordonii
... Streptococcus gordonii is a nonpathogenic gram-positive commensal bacterium and component of the normal microbial flora of the human oral cavity (13) which was developed as a vaccine vector (20, 24, 26). A ...
7
Listeria monocytogenes as a Biologic Vaccine Vector Against Feline Immunodeficiency Virus
... biologic vaccine vector against HIV because it induces a strong cell mediated immune response, can be delivered by mucosal routes, can be readily manipulated to express viral antigens, and is easy and ...
153
Evaluation of Toxoplasma gondii as a live vaccine vector in susceptible and resistant hosts
... cine vector. A commercial live vaccine strain S48 or avirulent no cyst-forming strains of ...live vaccine vector in ani- mals in the future ...
9
Characterization of a Single-Cycle Rabies Virus-Based Vaccine Vector
... Recombinant rabies virus (RV)-based vectors have demonstrated their efficacy in generating long-term, antigen-specific immune responses in murine and monkey models. However, replication-competent viral vectors pose ...
12
Assessment of Lactobacillus gasseri as a Candidate Oral Vaccine Vector
... a vaccine vector for oral immunization against mucosal ...the vector, a plasmid containing fliC, the gene encoding bacterial flagellin, was introduced which resulted in the strong activation of ...
11
Innate Immunogenicity of Lactobacillus as a Mucosal Vaccine Vector.
... a vaccine vector since its surface layer protein binds the CLR DC-SIGN, cell wall lipotechoic acid activates TLR2, and peptidoglycan-derived muramyl dipeptide activates the NLR, NOD2, and caspase 1 ...
339
IBV : potential as a vaccine vector and identification of a novel subgenomic mRNA
... replacement of Gene 5 proved to be the most successful in terms of both stability and protein expression while the replacement of ORFs 3a and 3b was found to be the least stable. The type of heterologous gene inserted ...
247
A Replication-Incompetent PB2-Knockout Influenza A Virus Vaccine Vector
... egg-based vaccine propagation is the selection of variants adapted to embryonated chicken eggs at the time of implementation, the virus in the vaccine may be slightly different from the circulating viruses ...
6
Novel Concepts for HIV Vaccine Vector Design
... Copenhagen vaccine strain) and MVA and (ii) avipoxvirus-derived ALVAC (canarypox virus) and fowlpox ...ALVAC vector was particularly attractive because of the lack of preexisting antivector immunity in ...
15
Recombinant Lactobacillus as a Vaccine Vector for HIV
... viral vaccine vectors including modified vaccinia virus (Robinson H et al, 1999), adenovirus ( Shiver JW et al, 2002), rabies virus (Schnell MJ et al, 2000), flavivirus (Mandl et al, 1998), murine leukemia virus ( ...
100
Recombinant Newcastle Disease Virus as a Vaccine Vector
... An important application of reverse-genetic techniques is the generation of recombinant viruses for use as vaccine vec- tors (reviewed in references 4, 8, 19, 21, and 26). A number of recombinant negative-strand ...
6
Immunogenicity and Cross-Reactivity of Rhesus Adenoviral Vectors
... as vaccine vectors due to their safety profile and immunogenicity (1, ...of vector-specific NAbs have been shown to attenuate the humoral and cellular immune responses elicited by these vectors due to ...
15
Vaccination of Macaques with DNA Followed by Adenoviral Vectors Encoding Simian Immunodeficiency Virus (SIV) Gag Alone Delays Infection by Repeated Mucosal Challenge with SIV
... HIV vaccine development and testing. In this vaccine model, T cell control of virus load has been achieved by vaccination with replication-defective adenovirus (rAd) vectors and other nonpersistent virus ...
15
Overcoming Immunity to a Viral Vaccine by DNA Priming before Vector Boosting
... a vaccine modality that has proven particularly effective in animal models ...same vector, prior immunity to the viral vaccine vector has become a ...a vector for the delivery of ...
5
undvacc[EDocFind.com].pdf
... a vaccine against the bacterium, 115,000 to 270,000 people suffered from whooping cough each year in the United States; 5,000 to 10,000 of those died from ...the vaccine was introduced in the United States ...
59
A critical assessment of vector control for Dengue prevention
... Decreasing dengue will require increased capacity for informed preventive, versus the cur- rent reliance on reactive, vector control efforts that use existing and/or novel interventions with improved, more ...
19
Multi-walled carbon nanotubes increase antibody-producing B cells in mice immunized with a tetravalent vaccine candidate for dengue virus
... Thus, this study aims to assess the MWCNTs’ (carboxylated or not) efficiency in the increase in expression of the tetravalent vaccine candidate (TVC) plasmid vector for dengue virus in [r] ...
12