Valosin-containing protein
Original Article Associations of valosin-containing protein gene polymorphisms with hepatocellular carcinoma: a case-control study in a Chinese Han population
... operation. Valosin-containing protein (VCP) is a member of the ATPase associated with lots of cellu- lar activities (AAA) ...teasome-mediated protein degradation, mem- brane fusion, ...
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Valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal
... Valosin-containing protein (VCP)/p97 is a ubiquitously expressed protein belonging to the AAA+ (ATPases As- sociated with diverse cellular Activities) protein family with two ATPase ...
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Genome-Wide Screen Reveals Valosin-Containing Protein Requirement for Coronavirus Exit from Endosomes
... 6 Valosin-containing protein (VCP) depletion leads to accumulation of viral particles in early endosome ...N protein (rIBV-FlagN) for 4 h, fixed, permeabilized, and stained for EEA1 ...
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Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant
... Valosin-containing protein (VCP) is a ubiquitous member of the AAA-ATPase supergene ...-dependent protein degradation [1], chromatin- associated protein degradation [2], messenger ...
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Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons
... Mutations in the gene encoding valosin-containing protein (VCP) lead to multisystem proteinopathies including fronto- temporal dementia. We have previously shown that patient- derived VCP mutant ...
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Affinity Purification of the Hepatitis C Virus Replicase Identifies Valosin-Containing Protein, a Member of the ATPases Associated with Diverse Cellular Activities Family, as an Active Virus Replication Modulator
... identified valosin-containing protein (VCP), a member of the ATPases associated with diverse cellular activities (AAA ⴙ ATPase) family, as an active viral replication modulator whose ATPase activity ...
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Sorafenib Impedes Rift Valley Fever Virus Egress by Inhibiting Valosin-Containing Protein Function in the Cellular Secretory Pathway
... p97/ valosin-containing protein (VCP), which is involved in membrane remodeling in the secretory pathway and a known target of sorafenib, was found to be impor- tant for RVFV ...
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Valosin-Containing Protein (VCP/p97) Is Required for Poliovirus Replication and Is Involved in Cellular Protein Secretion Pathway in Poliovirus Infection
... Antiviral candidates have served as useful tools for the study of PV infection in addition to their potential use in therapy. Antivi- rals for PV have been identified at every stage of PV infection, including binding to ...
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From neurodevelopment to neurodegeneration: the interaction of neurofibromin and valosin-containing protein/p97 in regulation of dendritic spine formation
... Statin, an inhibitor of 3-hydroxy-3-methylglutaryl- coenzyme A (HMG-CoA) reductase, has been shown to rescue the learning and attention deficits of Nf1 mutant mice [78]. HMG-CoA reductase is the rate-limiting enzyme of ...
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Valosin containing protein and neurofibromin interact to regulate dendritic spine density
... this protein detected in the Myc antibody precipitate may correspond to aggregates of oxidized CSRD protein generated during antibody and protein A ...and protein A (from 4 to 3 hours) and ...
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Upregulation of valosin-containing protein (VCP) is associated with poor prognosis and promotes tumor progression of orbital B-cell lymphoma
... Notes: The apoptosis rate of the siVcP group was more than the nc and mock groups (P , 0.05). (A) cells containing bright-blue particles (apoptosis-positive cells) were visualized under fluorescence microscopy. ...
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The involvement of endoplasmic reticulum formation and protein synthesis efficiency in VCP- and ATL1-related neurological disorders
... including Valosin-containing protein (VCP), Atlastin-1 (ATL1), Spastin (SPAST), Reticulon 2 (RTN2), Receptor expression enhancing protein 1 (REEP1) and RAB10 — suggesting a critical role of ER ...
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Mutational Analysis of the Drosophila homothorax Gene
... taining protein of the MEIS family (PREP and MEIS the MEIS family and it also contains a proline-tyrosine- in mammals, HTH in Drosophila, Ceh 25 in Caenorhab- proline sequence that is common to all members of the ...
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Heterologous expression of family 10 xylanases from Acidothermus cellulolyticus enhances the exoproteome of Caldicellulosiruptor bescii and growth on xylan substrates
... The architecture of these xylanases may also play a role in their activity. For example, the large multifunctional xylanases containing a GH10 in C. bescii may get trapped in non-productive binding on these ...
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Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems
... inhibits protein kinase C [73] and insulin signalling [74], both involved in up- regulation of α-cleavage [75] (Figure 2, line 5) - and additionally may negatively feedback on APP expression and its own production ...
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The cloning and characterisation of link1: A LIM-domain containing protein kinase
... and protein kinase C lie within the proline/serine-rich region connecting the LIM and kinase ...and protein kinase C are key regulatory molecules of overlapping ...the protein kinases MAPKAP-2 ...
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A Preliminary Study on the Dietary Protein Requirement of Parachanna obscura (Günther, 1861) Larvae
... Parachanna obscura is the most common species among African Snakeheads (Bonou and Teugels, 1985). Characteristics of this fish that make it a desirable species in aquaculture are its high market value, rapid growth, ...
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Evaluation of vegetable protein in canine diets: assessment of performance and apparent ileal amino acid digestibility using a broiler model
... DCon = Control diet containing poultry meal as the main protein source DPr = Partial replacement with vegetable protein, formulated on total protein basis DAA = Partial replacement with [r] ...
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Evaluating the Effect of Protein A Signal Peptide on Extracellular Expression of Recombinant Hirudin in E.Coli
... the cells were lysed using sonicator. After centrifugation, the supernatant contained residual soluble proteins and the cell pellet contained the insoluble protein. Lyophilizer equipment was used to concentrate ...
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The arrestin-domain containing protein AdcA is a response element to stress
... Given that hyperosmolarity evokes AdcA phosphoryl- ation, we tried to position AdcA relatively to known me- diators of the osmoresponse. In response to the osmotic shock, vegetative cells like starving cells shrink ...
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