Valproic acid (VPA)
![Histone Deacetylase Inhibitor Valproic Acid and Cancer [Retracted]](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
Histone Deacetylase Inhibitor Valproic Acid and Cancer [Retracted]
... Valproic acid (VPA) is a short chain fatty acid with a long history of clinical use as an anticonvulsant ...drug. VPA has been shown to function as an HDAC inhibitor, leading to the ...
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3′,4′-Dimethoxyflavone and valproic acid promotes the proliferation of human hematopoietic stem cells
... was valproic acid ...example, VPA) have been successfully used for more than 2 decades, for the treatment of neurodegenerative ...disorders. VPA has been used as a first-line treatment drug ...
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Inactivation of beef brain alpha ketoglutarate dehydrogenase complex by valproic acid and valproic acid metabolites Possible mechanism of anticonvulsant and toxic actions
... anticonvulsant valproic acid (VPA, 2-n-propylpentanoic acid) causes inhibition of the citric acid cycle and elevations of central nervous system (CNS) gamma-aminobutyric acid ...
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A rapid and simple procedure for monitoring valproic acid by gas chromatography
... The method specificity was evaluated by comparing the chro- matograms obtained from the samples containing VPA and IS with those obtained from blank samples. A number of drugs were added to blank plasma and were ...
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Original Article Induction of apoptosis and autophagy in metastatic thyroid cancer cells by valproic acid (VPA)
... of valproic acid (VPA) on the inhibition of RET signaling and induction of apoptosis in human thyroid carcinoma ...cells. VPA inhibited the viability of ARO and WRO cells and also inhibited ...
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Pancreatitis Associated with Valproic Acid Therapy
... A review of the literature reveals no previous reports of elevated amylase and clinical signs of pancreatitis associated with valproic acid therapy. While direct evidence pinpointing VPA[r] ...
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Valproic Acid Induces Endocytosis-Mediated Doxorubicin Internalization and Shows Synergistic Anti-Proliferation Effects in Hepatocellular Carcinoma Cells
... of valproic acid (VPA) and doxorubicin (DOX) in hepatocellular carcinoma (HCC) and identified a specific and efficient, synergistic anti-proliferative effect of the VPA and DOX combination in ...
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Valproic Acid Sensitizes Chronic Lymphocytic Leukemia Cells to Apoptosis and Restores the Balance Between Pro- and Antiapoptotic Proteins
... that valproic acid (VPA), a well-es- tablished histone deacetylase (HDAC) inhibitor, mediates apoptosis in CLL cells ex vivo through caspase activation via both the extrinsic and the intrinsic ...
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Effects of amoxicillin/clavulanic acid on the pharmacokinetics of valproic acid
... Abstract: Valproic acid (VPA) is mainly metabolized via glucuronide, which is hydrolyzed by β-glucuronidase and undergoes enterohepatic ...Amoxicillin/clavulanic acid (AMC) administration ...
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Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents
... combining VPA with DNA demethylating agents ...of VPA. The studies of VPA plus ATRA in older patients suggests that it may be difficult to reach the ordinary therapeutic serum levels of VPA in ...
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Molecular dissection of the valproic acid effects on glioma cells
... agents. Valproic acid (VPA) is a histone deacetylase inhibitor that apart from its anticonvulsive effects in some retrospective studies has been suggested to lead to a superior outcome of ...
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Valproic acid ameliorates coxsackievirus B3 induced viral myocarditis by modulating Th17/Treg imbalance
... [12]. Valproic acid (VPA), a short-chain branched fatty acid, is a clinic- ally approved HDAC inhibitor that is traditionally used in the treatment of epilepsy and has been shown to be a safe, ...
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Original Article Valproic acid (VPA) suppresses the expression of SMAD4 in prostate carcinoma by up-regulating miR-34a
... that valproic acid (VPA) suppresses prostate carcinoma (PCa) cell metastasis and down-regulates SMAD4 protein ...which VPA regulates the expression of SMAD4 in PCa cells remains ...after ...
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Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report
... valproic acid. Thereafter, she restarted treatment with the low-dose valproic acid in an attempt to control her ...the valproic acid ...
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The Spectrum of Valproic Acid–Associated Pancreatitis
... RESULTS. Twenty-two patients with valproic acid–associated pancreatitis were seen during the study period. Symptoms were similar to those of patients with pancre- atitis from other etiologies and included ...
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Role of valproic acid in the treatment of bipolar disorder
... tolerability, Valproic Acid plays a major role, also in view of the relative safety and ease of handling compared to lithium, carbamazepine and atypical ...
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Virtual screening and molecular dynamics simulation suggest Valproic acid Co-A could bind to SARS-CoV2 RNA depended RNA polymerase
... i.e., valproic acid co-A was subjected to docking with RNA dependent RNA polymerase of SARS-CoV2, nsP12 (PDB id 6NUR), which has similar catalytic architecture as dengue RdRp nsP5 ...the valproic ...
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Valproic Acid-Induced Hyperammonemia in the Elderly: A Review of the Literature
... Valproic acid is a broad-spectrum antiepileptic drug that is approved for the treatment of several types of ...[1]. Valproic acid and its derivatives have been found to be useful and generally ...
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The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia
... of valproic acid in the treatment of human acute myeloid leukemia (AML); a summary of the previous clinical results from studies of valproic alone, valproic acid + all-trans retinoic ...
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Hallucinations After Withdrawal of Valproic Acid
... taking VPA up to a dose of 30 mg/kg per day, resulting in freedom from ...withdrew VPA over a period of 6 ...of VPA, she presented with an increase of oppositional behavior with agitation and racing ...
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