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Vascular biology

Endothelial cell culture: beginnings of modern vascular biology

Endothelial cell culture: beginnings of modern vascular biology

... vascular biology. It is apparent that two key variables were crucial in focusing attention on the work: (1) easy availability of a source tissue (umbilical vein) to isolate and grow a relatively pure ...

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Perspectives series: cell adhesion in vascular biology  Integrin signaling in vascular biology

Perspectives series: cell adhesion in vascular biology Integrin signaling in vascular biology

... Affinity modulation as a form of signal transduction is di- rectly relevant to vascular biology. First, several antithrom- botic drugs (e.g., aspirin, ticlopidine, clopidogrel, phosphodi- esterase ...

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Nuclear receptors in vascular biology

Nuclear receptors in vascular biology

... of vascular nuclear receptors including peroxisome proliferator activated receptors (PPAR- , farnesoid X receptor (FXR), the small heterodimer partner (SHP), the pregnane X ...

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Pediatric Prevention of Atherosclerosis: Targeting Early Variation in Vascular Biology

Pediatric Prevention of Atherosclerosis: Targeting Early Variation in Vascular Biology

... in vascular biology on long-term risk of cardiovas- cular disease will generate a scientific evidence base to allow us to design robust proposals for novel pediatric prevention strategies for ...

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Impact of AT2-receptor stimulation on vascular biology, kidney function, and blood pressure

Impact of AT2-receptor stimulation on vascular biology, kidney function, and blood pressure

... on vascular remodeling, and studies that measured the net effect of AT2R stimula- tion on BP in ...hypertension-induced vascular remodeling and reduce arterial stiffening, which in more chronic settings and ...

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Abstracts from the 13th International Conference on Cerebral Vascular Biology (CVB 2019)

Abstracts from the 13th International Conference on Cerebral Vascular Biology (CVB 2019)

... of vascular commitment, which kinases/phosphatases dysregulation, alteration of tissue clearance and reduced ...the vascular arise (stroke, CADASIL and Alzheimer); involving pro-inflammatory markers and ...

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Perspectives series: cell adhesion in vascular biology  Smooth muscle migration in atherosclerosis and restenosis

Perspectives series: cell adhesion in vascular biology Smooth muscle migration in atherosclerosis and restenosis

... However, it is likely that other morphogenic processes are involved in atherosclerosis. For example, vascular narrowing may well depend on some form of smooth muscle migration. The size of atherosclerotic plaques ...

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Perspectives series: cell adhesion in vascular biology  Adhesive interactions of sickle erythrocytes with endothelium

Perspectives series: cell adhesion in vascular biology Adhesive interactions of sickle erythrocytes with endothelium

... cluding those allowing red cell rolling) are not identified. Moreover, in vitro studies have thus far examined adhesion only on flat surfaces, corresponding best to a vessel having an infinite radius of curvature. Yet ...

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Review Article The roles of cytochromes P450 in vascular biology and cardiovascular homeostasis

Review Article The roles of cytochromes P450 in vascular biology and cardiovascular homeostasis

... Consistent evidence supports the importance of COX-derived eicosanoids in atherogenesis as well as the benefit of COX inhibition in decreas- ing atherosclerosis [77]. The use of aspirin, a COX-1 inhibitor, for secondary ...

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A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability

A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability

... Impaired endothelial production of prostacyclin (PGI2) and nitric oxide (NO) in early arterial lesions facilitate vasoconstriction, inflammation and oxidative stress at a time when no morphological changes in the vessel ...

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Perspectives series: cell adhesion in vascular biology  Role of PSGL 1 binding to selectins in leukocyte recruitment

Perspectives series: cell adhesion in vascular biology Role of PSGL 1 binding to selectins in leukocyte recruitment

... These include defining the details of the posttranslational modifications that confer optimal PSGL-1 binding to selectins, the nature of the molecular contacts between lectin and ligand,[r] ...

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Egyptian Association of Vascular Biology and Atherosclerosis (EAVA) consensus on the usage of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors

Egyptian Association of Vascular Biology and Atherosclerosis (EAVA) consensus on the usage of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors

... Having revised the evidence from the cardiovascular outcome studies with PCSK9 inhibitors as well as from the available Egyptian data as we showed, we can con- clude that addition of a P[r] ...

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Engineering Patterns to Study Vascular Biology

Engineering Patterns to Study Vascular Biology

... understood, a growing number of studies utilizing these materials and their interactions with cells as a means of repairing or replacing injured tissues quickly coalesced into its own field (Vacanti, 2012). Today, tissue ...

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Analysis of clonality and vascular biology in Hepatocellular carcinoma

Analysis of clonality and vascular biology in Hepatocellular carcinoma

... Each group of SK-Hep-1 cells (wild-type, plasmid vector transfected, TSP1. transfected) were seeded into the upper chamber of the modified Boyden[r] ...

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Vascular biology and bone formation: hints from HIF

Vascular biology and bone formation: hints from HIF

... In their current study, Wang, Clemens, and colleagues (3) significantly advance our understanding of bone-vascular coupling by establishing the critical role for osteo- blast hypoxia-inducible factor 1α (HIF-1α) ...

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Cell adhesion in vascular biology  New insights into integrin ligand interaction

Cell adhesion in vascular biology New insights into integrin ligand interaction

... In an analogous model of integrin allostery, the b subunit I-domain structure would sit on top of the a subunit propeller in the low affinity quaternary state, where it sterically blocks[r] ...

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Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine

Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine

... Endothelial progenitor cells (EPCs) were first isolated from adult peripheral blood (PB) in 1997 [1]. Circulating EPCs are bone marrow (BM)-derived cells that incorporate into the foci of physiological or pathological ...

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Viruses in Biology

Viruses in Biology

... Finally, virocentric ideas on the origin-of-life were large- ly abandoned in the 1960s and throughout the remainder of the twentieth century due to two major factors. The first had to do with the nature of viruses ...

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Stem cell biology meets systems biology

Stem cell biology meets systems biology

... Cell Biology and Genetics, Dresden, Germany), who presented the results of a genome-wide RNAi screen for genes that affect ES cell identity via alteration of Oct4 expression (Ding et ...

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Biology Unit Biology B1b (Evolution and Environment)

Biology Unit Biology B1b (Evolution and Environment)

... In graph 1 , what percentage of the people surveyed in Town 1 would buy GM foods, but would like more information about them.. 1 28 %.[r] ...

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