Vascular integrity
CHD4 regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity
... The chromatin-remodeling enzyme CHD4 maintains vascular integrity at mid-gestation; however, it is unknown whether this enzyme contributes to later blood vessel or lymphatic vessel development. Here, we ...
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The FGF system has a key role in regulating vascular integrity
... The integrity of the endothelial monolayer is essential to blood vessel homeostasis and active regulation of endothelial permeability. The FGF system plays important roles in a wide variety of physiologic and ...
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Cis element mutated in GATA2 dependent immunodeficiency governs hematopoiesis and vascular integrity
... ling vascular integrity (48, 49), and FERMT3 knockdown in human endothelial cells disrupted integrin-dependent adhesion and tube formation (50), one would predict that the simultaneous downreg- ulation of ...
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Absence of endothelial α5β1 integrin triggers early onset of experimental autoimmune encephalomyelitis due to reduced vascular remodeling and compromised vascular integrity
... and vascular remodeling occur in a similar time-frame to BBB disruption, one interpretation is that vascular remodeling is an endogenous attempt to repair the damaged blood vessels and re-establish vascu- ...
11
Endothelial nitric oxide synthase, vascular integrity and human exceptional longevity
... maintaining vascular integrity during aging by activating vasorelaxation and allowing migration and ...of vascular integrity and nitric oxide production in determining healthy ...
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Notch3 establishes brain vascular integrity by regulating pericyte number
... brain vascular integrity, permeability and blood ...brain vascular development whereby Notch3 signaling promotes expansion of the brain pericyte ...
11
The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity
... to vascular fragility that led to severe edema and hemorrhage. Vascular ECs in RAMP2 –/– embryos were severely deformed and detached from the basement ...to vascular hyperpermeability and impaired ...
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KLF2 and KLF4 control endothelial identity and vascular integrity
... acute vascular dysfunction and death. The profound vascular defects seen in EC-DKO mice are likely a combined result of vascular barrier disruption as well as a generalized state of consumptive ...or ...
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Platelet ITAM signaling is critical for vascular integrity in inflammation
... platelet-dependent vascular integrity in the lung and skin are consistent with a tis- sue-independent source of podoplanin as the trigger of platelet CLEC2 ...
10
Preserved vascular integrity and enhanced survival following neuropilin-1 inhibition in a mouse model of CD8 T cell-initiated CNS vascular permeability
... cytokine, vascular endothelial growth factor (VEGF), has been strongly implicated in vascular ...the vascular perme- ability condition associated with Dengue hemorrhagic fever (DHF) as well as ...
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Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure
... Increased vascular leakage after ablation of ...the vascular leakage was further increased in BMK1-CKO mice after topical application of mustard oil, an inflammatory agent that induces vascular ...
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Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy
... cerebrovascular integrity, including taxifolin, need not reach neurons through the BBB [42], providing advantage for clinical application as drug delivery is a frequent problem in the development of novel ...
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The impact of crystalloidal and colloidal infusion preparations on coronary vascular integrity, interstitial oedema and cardiac performance in isolated hearts
... Actual shedding of the endothelial glycocalyx was obviously not initiated by any solution or condition simu- lated, as demonstrated by no increase in the glycocalyx constituent syndecan-1 in coronary effluent, no morpho- ...
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The Role of Sirtuin 6 in Maintaining Vascular Integrity
... of vascular pathologies that make them of particular interest to this ...all vascular cells ...ECs, vascular SMCs, and adventitial fibroblasts [10] and activated by vascular injury ...
106
In Vivo Assessment of Pulmonary Vascular Integrity in Experimental Pulmonary Edema
... to vascular damage by alloxan, we studied [ 51 Cr]erythrocytes (r), [ 125 I]albumin (a), [ 14 C]urea (u), and tritiated water as dilution indicators in the pulmonary circulation of anesthetized ...
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Endothelial pyruvate kinase M2 maintains vascular integrity
... driver of oncogenic metabolism. In contrast, the role of PKM2 in nontransformed cells is little studied, and nearly nothing is known of its role, if any, in quiescent cells. We show here that endothelial cells express ...
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Ebola Hemorrhagic Shock Syndrome-on-a-Chip
... Here, we describe a simple chip-based model of Ebola-induced vascular integrity loss. To provide the proof-of-principle for this approach and to ensure that the platform can be extended to a low-cost, ...
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Recombinant angiopoietin 1 restores higher order architecture of growing blood vessels in mice in the absence of mural cells
... in vascular remodeling and maintenance of vascular ...organized vascular architecture, comprising distinct artery, vein, and capillary, from a simple mesh- like ...a vascular network was ...
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The Role of Epithelial and Vascular-Endothelial Cadherin in the Differentiation and Maintance of Tissue Integrity
... of vascular integrity and permeability in adults ...of vascular development in mesodermal cells of the yolk sac ...in vascular permeability ...the vascular endothelial lining by direct ...
5
Andes Virus Regulation of Cellular MicroRNAs Contributes to Hantavirus-Induced Endothelial Cell Permeability
... and vascular integrity were increased ⬎ 4-fold following infection, while one miRNA associated with the regulation of Robo1, a receptor that counters Robo4 regulation of VEGF responses, was downregulated ...
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