Vascular remodelling
Simultaneous imaging of blood flow dynamics and vascular remodelling during development
... Normal vascular development requires blood ...image vascular structure and blood flow velocity, but these techniques lack the resolution to accurately calculate fluid forces such as shear ...vascular ...
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Chronic obstructive pulmonary disease phenotype desaturator with hypoxic vascular remodelling and pulmonary hypertension obtained by cluster analysis
... initiates vascular remodelling leading to perman- ent changes in pulmonary vasculature ...hypoxia-driven vascular changes ...that vascular changes contribute to vascular ...
7
Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF-β signalling: implications for PAH vascular remodelling
... resulting in protein expression in recipient HPAECs. Thus, mRNAs transported to HPAECs may lead to func- tional activation. To test this, we analysed two markers of EndoMT and vascular remodelling, ...
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Inhibition of vascular remodelling in a porcine coronary injury model by herbal extract XS0601
... diet, remodelling accounted for 59% of late lumen loss, and intimal hyperplasia, ...and vascular remodelling were attributed to late lumen loss in this porcine coronary injury ...arterial ...
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Basement membrane and vascular remodelling in smokers and chronic obstructive pulmonary disease: a cross-sectional study
... and vascular remodelling in large airway biopsies in current smokers with normal lung function and patients with established mild to moderate ...fragmentation. Vascular changes in the Rbm and LP were ...
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Magnetic resonance imaging of local and remote vascular remodelling after experimental stroke.
... Ling et al. 30 found that post-stroke secondary degen- eration in the thalamus may be accompanied by angio- genesis and neurogenesis. In addition to neuronal loss and microglial activation in the ipsilateral VPN at days ...
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The role of 14q32 microRNAs in vascular remodelling
... DŝĐƌŽZEƐĂƌĞƐŚŽƌƚ͕ŶŽŶͲĐŽĚŝŶŐZEŵŽůĞĐƵůĞƐƚŚĂƚƌĞŐƵůĂƚĞƚŚĞĞdžƉƌĞƐƐŝŽŶŽĨƚŚĞŝƌƚĂƌŐĞƚŐĞŶĞƐ Ăƚ ƚŚĞ ƉŽƐƚͲƚƌĂŶƐĐƌŝƉƟŽŶĂů ůĞǀĞů ϯ ͘ ĂĐŚ ŵŝĐƌŽZE ŚĂƐ ŵƵůƟƉůĞ ƚĂƌŐĞƚ ŐĞŶĞƐ ĂŶĚ ŵŝĐƌŽZEͲďŝŶĚŝŶŐ ƚŽĂƚĂƌŐĞƚŵ[r] ...
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Neutralizing S1P inhibits intratumoral hypoxia, induces vascular remodelling and sensitizes to chemotherapy in prostate cancer
... new vascular network [35, ...including vascular endothelial (VE)-cadherin [65], VEGF causes VE-cadherin destabilization hence a loosening of endothelial cell association ...of vascular function ...
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Progenitor cell mobilisation and recruitment in pulmonary arteries in chronic obstructive pulmonary disease
... pulmonary vascular remodelling, pulmonary function and CS exposure In COPD patients, the number of circulating PCs or bone marrow-derived cells localized in pulmonary arter- ies was unrelated to the ...
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The role of the bronchial microvasculature in the airway remodelling in asthma and COPD
... during vascular remodelling in bron- chial asthma ...airway vascular permeability index as measured by the albumin in induced sputum/albumin in serum [28-31], or as fibronectin concentrations [32] or ...
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Preclinical Imaging Biomarkers for Postischaemic Neurovascular Remodelling
... as vascular remodelling and reorganisation, there is a need for recognising the capabilities and limitations of in vivo imaging ...neuro- vascular changes in small ...neurovascular remodelling ...
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Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodeling in a hypoxic model of pulmonary arterial hypertension
... remodelling and pro-in fl ammatory changes. Current treatments for PAH are targeted at improving pulmonary haemodynamics, exercise tolerance and quality of life. Currently licenced drugs for treating PAH are all ...
10
Pulmonary arterial remodelling by deficiency of peroxisome proliferator-activated receptor-γ in murine vascular smooth muscle cells occurs independently of obesity-related pulmonary hypertension
... Clinical and experimental observations suggest a connection between obesity, insulin resistance and VSMC-driven vascular remodelling including PAH [9, 10], while the molecular mechanisms remain elusive. ...
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Precision medicine and personalising therapy in pulmonary hypertension: seeing the light from the dawn of a new era
... pulmonary vascular lesions of ...pulmonary vascular lesions [69] and the presence of lymphoid neogenesis in lungs have been demonstrated in patients with PAH [70, ...pulmonary vascular ...
9
The crosstalk between vascular MSCs and inflammatory mediators determines the pro-calcific remodelling of human atherosclerotic aneurysm
... [15]. Vascular remodelling and inflammatory process are tightly connected, because inflammatory me- diators stimulate the MMP expression in different bio- logical contexts [16–18]; moreover, a relation has ...
13
Fibrocytes are associated with vascular and parenchymal remodelling in patients with obliterative bronchiolitis
... for remodelling in OB, and the vascular remodelling in these patients might facilitate an increased influx of fibrocytes into the ...structural remodelling of both the pulmonary ves- sels and ...
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Aortic remodelling during hemogenesis: is the chicken paradigm unique?
... al., 2008). Double positive QCPN (a pan-quail marker)- SMA cells were clearly visible following sclerotome graft (Fig. 3 G,H). In contrast, the dermomyotome gives rise to angioblasts but never to cells of the ...
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Chromatin remodelling during plant pathogen interactions
... In addition to developmental cues, biotic or abiotic stress can also lead to rapid changes in chromatin dynamics, mediated by different chromatin remodelling processes. Studies with cultured animal cells have ...
222
Mechanical Assessment of the Risk of Atherosclerotic Plaque Rupture in Carotid Arteries with a Focus on Damage Accumulation
... a remodelling metric was also defined to characterise the lack of remodelling in the diseased carotid bifurcations in terms of lack of collagen fibre ...This remodelling metric has the potential to ...
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Age dependent remodelling of ionotropic signalling in cortical astroglia
... The development and ageing of the brain is associated with remodelling of synaptic contacts and plastic changes in neural networks. The formation, maintenance and modification of these networks depend on the ...
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