Vascular smooth muscle cells (VSMCs)
Exosomes from hyperglycemia-stimulated vascular endothelial cells contain versican that regulate calcification/senescence in vascular smooth muscle cells
... endothelial cells; VSMCs: vascular smooth muscle cells; ROS: reactive oxy‑ gen species; ALP: alkaline phosphatase; Runx2: Runt‑related transcription fac‑ tor; HUVECs: human ...
15
Original Article GDF-15 promotes proliferation of vascular smooth muscle cells through MAPK-activated protein kinase pathways
... which vascular smooth muscle cells (VSMCs) mainly derived from the medial layer of the blood vessel play a pivotal role in atherogene- ...sis. VSMCs proliferation is one of the ...
8
Original Article Cholesterol induces dedifferentiation of vascular smooth muscle cells by regulating monocyte chemotactic protein-1-induced protein 1
... of VSMCs in vitro and the underly- ing mechanisms. Methods: Vascular smooth muscle cells (VSMC) were employed to evaluate the role of choles- terol in regulating the dedifferentiation ...
10
In Vitro Effects of Curcumin on Transforming Growth Factor-β-mediated Non-Smad Signaling Pathway, Oxidative Stress, and Pro‐inflammatory Cytokines Production with Human Vascular Smooth Muscle Cells
... of vascular smooth muscle cells (VSMCs) which promote to the progression of atherosclerotic ...endothelial cells (ECs) and vascular smooth muscle ...
10
Immune interferon inhibits proliferation and induces 2' 5' oligoadenylate synthetase gene expression in human vascular smooth muscle cells
... of vascular smooth muscle cells (SMC) contributes to formation of the complicated human atherosclerotic ...T cells secrete immune IFN-gamma locally in the ...
10
Insulin and insulin like growth factor I differentially induce alpha1 adrenergic receptor subtype expression in rat vascular smooth muscle cells
... of cells with insulin or IGF-I enhanced subsequent norepinephrine stimulation of mitogen activated kinase ...in VSMCs and potentially enhance the effects of catecholamines in settings of ...
10
Pioglitazone modulates the proliferation and apoptosis of vascular smooth muscle cells via peroxisome proliferators-activated receptor-gamma
... After cell treatment, VSMCs were washed with phosphate- buffered saline (PBS) and lysed in RIPA buffer (Biotech, Shanghai, China). After one freeze/thaw cycle, lysates were centrifuged. Protein concentration was ...
10
Anti Proliferative Effects of Rutin on OLETF Rat Vascular Smooth Muscle Cells Stimulated by Glucose Variability
... rat VSMCs were obtained from enzymatically dissociated rat thoracic ...aortas. VSMCs were incubated for 72 h with alternating normal ...of VSMCs, the proliferative molecular pathway [including p44/42 ...
9
Angiotensin II receptor expression and relation to Helicobacter pylori-infection in the stomach of the Mongolian gerbil
... cortical cells in the zona glomerulosa (staining of the capsule surrounding the gland, vascular smooth muscle cells (VSMCs) and endothelial cells was also noted) in both ...
11
Hemodynamics, inflammation, vascular remodeling, and the development and rupture of intracranial aneurysms: a review
... response, vascular smooth muscle cells (VSMCs) phenotypic modulation, extracellular matrix remodeling, and subsequent cell death and vessel wall ...complement, VSMCs, mast ...
9
A Chinese herbal formula "Gan Lu Yin" suppresses vascular smooth muscle cell migration by inhibiting matrix metalloproteinase 2/9 through the PI3K/AKT and ERK signaling pathways
... blocking vascular endothelial growth factor (VEGF) protein expression of HUVEC ...induced VSMCs cells migration was ...on vascular smooth muscle cells and to evaluate its ...
12
The methanol seed extract of Garcinia kola attenuated angiotensin II- and lipopolyssacharide-inducedvascular smooth muscle cell proliferation and nitric oxide production
... of Vascular Smooth Muscle Cells (VSMCs) in cell culture by Angiotensin II (Ang II) and LPS-induced NO production were carried ...Confluent VSMCs were exposed to GK (25, 50 and ...
6
Original Article β-catenin in VSMC proliferation induced by fluid shear stress through the non-Wnt signaling pathway
... (FSS), vascular smooth muscle cells (VSMCs) proliferation during atherosclerosis (AS), and ...endothelial cells, the thickening and severe deformation of endangium, and the ...
10
PubMedCentral-PMC5009267.pdf
... in vascular smooth muscle cells has important physiological ...During vascular injury, activated platelets or other cells pro- duce TxA2, which in turn promotes platelet ...
12
Oxidative stress-dependent activation of collagen synthesis is induced in human pulmonary smooth muscle cells by sera from patients with scleroderma-associated pulmonary hypertension
... and vascular smooth muscle cells (VSMCs) ...conditions, VSMCs exhibit a contractile phenotype, which regulate blood vessel diam- eter by virtue of stretch-sensing ...During ...
5
Regulation of smooth muscle cell migration and integrin expression by the Gax transcription factor
... cultured vascular smooth muscle cells (VSMCs) upon stimula- tion by serum PDGF (6, 7) or angiotensin II (8), and in the rat carotid artery during the proliferative response to balloon ...
13
Original Article Chinese rice wine polyphenol compounds inhibit vascular smooth muscle cell dedifferentiation and its mechanism
... aortic vascular smooth muscle cells (VSMCs) dedifferentiation through mammalian target of rapamycin (mTOR)/P70S6K ...rat VSMCs was conducted and VSMCs in passages 3-5 were ...
10
Inflammation and intracranial aneurysms: mechanisms of initiation, growth, and rupture
... inflammatory cells. Dysfunction of the endothelium and vascular smooth muscle cells (VSMCs) promotes a chronic pathological inflammatory response that progressively weakens the ...
9
Original Article Xanthohumol inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration through suppression of PDGF signaling pathway
... of vascular smooth muscle cells (VSMCs) contribute to the development of ...aortic smooth muscle cells (HASMCs) proliferation and migration, the potential mechanism ...
7
A novel role for the cyclin dependent kinase inhibitor p27Kip1 in angiotensin II–stimulated vascular smooth muscle cell hypertrophy
... in VSMCs by transfection, using the lipid formulation Fugene (Boehringer Mannheim Biochemicals ...the cells. The medium was changed 24 hours later and left until the cells were ...when cells ...
10