Vasoactive intestinal peptide receptor
Importance of the Vasoactive Intestinal Peptide Receptor in the Stimulation of Cyclic Adenosine 3′,5′ Monophosphate in Gallbladder Epithelial Cells of Man: COMPARISON WITH THE GUINEA PIG
... maximal inhibition was observed at 2 nM. Scatchard analysis indicated two functionally independent classes of receptor sites: 62,000 high affinity sites/cell with a dissociation constant (K d ) of 1.3 nM, and ...
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Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
... with vasoactive intestinal peptide receptor 2 (Sigma, St Louis, MO), FITC-IgG (Sigma, St Louis, MO) and CD4-PE anti- mouse monoclonal antibodies and analysed on the flow cytometer with ...
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Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats
... direct pathway to the brain, the drugs reaching the brain parenchyma mainly by a paracellular route (Mathison et al., 1998; Illum, 2000). By intranasal administration, drugs not only circumvent the BBB, but they also ...
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Protective effect of vasoactive intestinal peptide on bone destruction in the collagen induced arthritis model of rheumatoid arthritis
... with vasoactive intestinal peptide (VIP) prevents experimental arthritis in animal models by downregulation of both autoimmune and inflammatory components of the ...(COX-2), receptor activator ...
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Vasoactive intestinal peptide prevents excitotoxic cell death in the murine developing brain
... Glutamate receptor antagonists and inhibitors of glutamate re- lease (for review see reference 9), free radical scavengers (59), growth factors including nerve growth factor (60), and insulin- like growth factor 1 ...
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Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension
... using vasoactive intes- tinal peptide, a neuropeptide primarily functioning as a neurotransmitter that acts as a potent sys- temic and pulmonary ...corresponding receptor sites as shown by Northern ...
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Inhibition of murine embryonic growth by human immunodeficiency virus envelope protein and its prevention by vasoactive intestinal peptide and activity dependent neurotrophic factor
... The mechanism of gp120-induced neurotoxicity is un- known. Earlier work from our laboratory indicated that gp120 acts indirectly to interfere with glial cell neurotrophic func- tions (16, 17). VIP stimulates the release ...
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Actin reorganization is involved in vasoactive intestinal peptide induced human mast cells priming to fraktalkine-induced chemotaxis
... c receptor on the cell surface, but will put the cell in the ready-to-go position to re-stimulation and will do so even with a suboptimal dose of the proper chemokine that attracts the cell ...
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Maternal vasoactive intestinal peptide and the regulation of embryonic growth in the rodent
... The recognized receptor for VIP is linked to adenylate cy- clase, and GTP sensitivity is characteristic of these receptors (29). The second messenger system through which the GTP- insensitive binding sites operate ...
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Effects of the vasoactive intestinal peptide (VIP) and related peptides on glioblastoma cell growth in vitro
... VIP receptor antagonists on the proliferation of C6 cells in culture: neurotensin-VIP; GRF antagonist; and VIP ...VIP receptor antagonists, compared to cell number observed without treatment (control) (0%) ...
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A comparison of the release of a vasoactive intestinal peptide like peptide and acetylcholine in the giant axon Schwann cell preparation of the tropical squid Sepioteuthis sepioidea
... VIP-like peptide is not required for activation of either of the two subclasses of NMDA receptor previously described to be present in this preparation (Evans 1991a, ...VIP-like peptide is blocked ...
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Vasoactive Intestinal Peptide (VIP) and VIP Receptors Elucidation of Structure and Function for Therapeutic Applications
... VIP receptor functions to inhibit the produc- tion of inducible nitric oxide synthase (iNOS), inhibit the production of the proinflammatory cytokine tumor ne- crosis factor (TNF)-α, and promote the production of ...
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Therapeutic effect of vasoactive intestinal peptide on form-deprived amblyopic kittens
... the receptor, VIP plays a physiological role through a series of signal transduction pathways, in- cluding the cAMP-dependent protein kinase pathway, alcohol phospholipid pathway, ornithine decarboxylase polyamine ...
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Vasoactive intestinal peptide induces S(alpha)/S(mu) switch circular DNA in human B cells
... (VIP1) receptor (38, 39, 45, 47, 48). That the VIP1 receptor could mediate this effect is supported by the recent finding that the VIP1 receptor gene is expressed at readily de- tectable levels in ...
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Glucose-targeted niosomes deliver vasoactive intestinal peptide (VIP) to the brain
... ical effect obtained was a peripheral vasodilation. We recently delivered with success intact VIP to the brain in rats, by using an intranasal route of administration (Dufes et al., 2003). Through this pathway, VIP not ...
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Prospect of vasoactive intestinal peptide therapy for COPD/PAH and asthma: a review
... Progressive pulmonary inflammation is the hallmark of airway diseases, including asthma, COPD and PAH. VIP has been shown to exert immunomodulating and anti- inflammatory activities through VIP specific receptors [74]. ...
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Role of vasoactive intestinal peptide in osteoarthritis
... nociception. The mechanism by which VIP exerts its pro-nociceptive effects includes the enhanced produc- tion of cAMP and enhanced protein kinase A activity through the stimulation of adenylyl cyclase [37]. VIP is ...
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Severe microcephaly induced by blockade of vasoactive intestinal peptide function in the primitive neuroepithelium of the mouse
... Vasoactive intestinal peptide (VIP) has potent growth-related actions that influence cell mitosis, neuronal survival, and neurodifferentiation in cell ...
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Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis
... regulator (CFTR), an anion channel whose dysfunction leads to chronic bacterial and fungal airway infections via a pathophysiological cascade that is incompletely understood. Airway glands, which produce most airway ...
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Prevention of hyperoxia-induced bronchial hyperreactivity by sildenafil and vasoactive intestinal peptide: impact of preserved lung function and structure
... or vasoactive intestinal peptide (VIP) is able to prevent the hyperoxia-induced development of ...of vasoactive intestinal peptide (VIP, Group HV) or sildenafil (Group ...
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