VEGF Pathway
Genome wide pathway analysis identifies VEGF pathway association with oral ulceration in systemic lupus erythematosus
... that VEGF cytokine could be directly implicated in the formation of oral ulcers in BD ...of VEGF have been also associated with oral ulceration ...the VEGF gene has been also associated with the risk ...
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Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy
... inhibiting VEGF is a primary approach to tumor vessel ...targeting VEGF pathway to normalize the ...depress VEGF pathway and make tumor vascular are ...
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Genetic biomarkers in the VEGF pathway predicting response to anti-VEGF therapy in age-related macular degeneration
... In our study, we assessed associations in patients with neovascular ARMD between the response to anti- VEGF treatment and SNPs in components of the VEGF pathway. We genotyped tagging SNPs near a ...
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VEGF pathway targeting agents, vessel normalization and tumor drug uptake: from bench to bedside
... (VEGF) pathway targeting agents have been combined with other anticancer drugs, leading to improved efficacy in carcinoma of the cervix, stomach, lung, colon and rectum, ovary, and ...by VEGF ...
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Original Article Proinflammatory-factors-carrying-microvesicles from monocytes induced by high glucose enhance the activation of HIF/VEGF pathway in human renal mesangial cells
... and VEGF in human renal mesangial cells after treatment with THP1-derived microvesicles were examined by western ...and VEGF in HRMC were augmented by ...HIF/VEGF pathway in human renal ...
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The role of HIF-1α-VEGF pathway in bronchiolitis obliterans after lung transplantation
... , VEGF-A, and VEGFR2 in BO after lung transplantation and found a link between these three ...that VEGF-A, as a target protein of HIF-1, has specific binding to the VEGFR2 transmembrane protein, activating ...
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Resveratrol ameliorates high-glucose-induced hyperpermeability mediated by caveolae via VEGF/KDR pathway
... Resveratrol (3,5,4 0 -trihydroxy-trans-stilbene, RSV), a kind of dietary polyphenol abundantly existed in red wine and Chinese herb rhizoma polygonum cuspidatum, might play an important role in ‘French paradox’ (Kopp ...
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The mTOR/AP-1/VEGF signaling pathway regulates vascular endothelial cell growth
... and VEGF, while overexpression of AP-1 (pAP-1) upregulated AP-1 and VEGF (Figure ...of VEGF combined with RAPA treatment inhibited mTOR expression, and RAPA alone or in combination with empty vector ...
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Tumor refractoriness to anti-VEGF therapy
... VEGF pathway inhibition may change the natural history of tumor progression after anti-angiogenic therapy and include potential metastasis promoting ...as VEGF and PlGF, or recruitment of EPCs that ...
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Normalization of Tumor Vasculature by Oxygen Microbubbles with Ultrasound
... Tumor microenvironment influences the efficacy of anti-cancer therapies. The dysfunctional tumor vasculature limits the efficiency of oxygenation and drug delivery to reduce treatment outcome. A concept of tumor vascular ...
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<p>Downregulation of miR-21 inhibits the malignant phenotype of pancreatic cancer cells by targeting VHL</p>
... VHL is a component of the protein complex that includes elongin B, elongin C and cullin-2, and possesses ubiquitin ligase E3 activity. When oxygen supply is ade- quate, hypoxia-inducible factor (HIF)-1 α is hydroxylated ...
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ADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress
... Notes: (A) relative mrna expression level of aDar1 genes in a time-course condition of hypoxia culture. gaPDh was used as housekeeping gene for normalization. (B) Western blot analysis of aDar1, FgFr2, VegF, and ...
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Vascular endothelial growth factor inhibitors: investigational therapies for the treatment of psoriasis
... of VEGF inhibitors are licensed for the treatment of malignancies and eye disease and isolated case reports suggest that some individuals with pso- riasis may improve when exposed to these ...of VEGF ...
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Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
... Elevated VEGF levels have been observed in tissues and biological samples from individu- als with ...the VEGF level in asthmatic subjects correlates closely ...
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BMP2 secretion from hepatocellular carcinoma cell HepG2 enhances angiogenesis and tumor growth in endothelial cells via activation of the MAPK/p38 signaling pathway
... of VEGF was lower in the H_oeBMP2 + SB-239063 group than that in the H_oeBMP2 + DMSO ...of VEGF, VEGF-C, MMP-2, MMP-9, and Vimentin were decreased obviously, while that of E- cadherin protein level ...
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Role of cytokines and chemokines in alcohol-induced tumor promotion
... There are a number of signaling pathways that are regulated by cytokines and chemokines and play an important role in tumorigenesis and progression. On the other hand, these signaling pathways can also modulate the ...
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Axitinib for the treatment of patients with advanced metastatic renal cell carcinoma (mRCC) after failure of prior systemic treatment
... to VEGF inhibitors, with multiple lines of prior therapy, patient selection differed substantially from the AXIS trial, where multiple agents were allowed, but prior lines of therapy were restricted to one ...
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Vandetanib (ZD6474) induces antiangiogenesis through mTOR–HIF-1 alpha–VEGF signaling axis in breast cancer cells
... target for this new drug. Our study showed that vandetanib specifically targets mTOR, HIF-1 alpha, and VEGF signal- ing pathway. This will help us identify the best target for treatment. A cancer with ...
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Effect of a Proprietary Commiphora mukul Gum Resin Extract and Medium-Chain Triglyceride Preparation (GU-MCT810) on hypoxia-inducible factor-1 pathway in HepG2 cell line
... HIF-1 pathway might be effective in the treatment of pancreatic cancer, which works through the suspension of glucose metabolism [23] and rendering the cells susceptible to ...
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Original Article Overexpression of both VEGF-A and VEGF-C in gastric cancer correlates with prognosis, and silencing of both is effective to inhibit cancer growth
... of VEGF-A and VEGF-C may reduce cancer growth, progression and lym- phatic ...either VEGF-A or VEGF-C in the biological behaviors of ...both VEGF-A and VEGF-C, who present with ...
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