Ventral tegmental area
Role of Orexin-1 Receptor Within the Ventral Tegmental Area in Mediating Stress- and Morphine Priming-induced Reinstatement of Conditioned Place Preference in Rats
... (ventral tegmental area) administration of SB334867 as an orexin-1 receptor (OX1R) antagonist on drug priming- and forced swim stress (FSS)-induced reinstatement of mor- ...
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Microinjection of Ghrelin into the Ventral Tegmental Area Potentiates Cocaine Induced Conditioned Place Preference
... Prior work has shown that systemic cocaine pretreatment augments cocaine conditioned place preference (CPP) in rats. In contrast, ghrelin receptor antagonism attenuates cocaine and amphetamine-induced CPP. In order to ...
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Functional Interaction between the Shell Sub-Region of the Nucleus Accumbens and the Ventral Tegmental Area in Response to Morphine: an Electrophysiological Study
... This study has examined the functional importance of nucleus accumbens (NAc)-ventral tegmental area (VTA) interactions. As it is known, this interaction is important in associative reward processes. ...
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Effect of Transient Inactivation of Ventral Tegmental Area on the Expression and Acquisition of Nicotine-Induced Conditioned Place Preference in Rats
... espite effective public health campaigns that have decreased tobacco use, smoking remains a predominant health troublesome. Smoking is essentially a myriad of behaviors reflecting addiction to nicotine, the major ...
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A Persistent Na+ Current and Its Contribution to Burst Like Firing in Ventral Tegmental Area Dopamine Neurons
... Ventral tegmental area dopamine (DA VTA) neurons project their axons to the nucleus accumbens (NAcb) [1]. Increases in the activity of mesoaccumbal dopamine system in the brain are critical for the ...
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Determination of circuit-specific morphological adaptations in ventral tegmental area dopamine neurons by chronic morphine
... Long-term use of opiates, such as morphine or her- oin, can have lasting effects within the mesocortico- limbic circuitry, particularly the ventral tegmental area (VTA) dopamine (DA) neurons, which ...
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The Effects of Zinc and Other Divalent Cations on M Current in Ventral Tegmental Area Dopamine Neurons
... Zinc Zn2+ Inhibits M-Current IM in Ventral Tegmental Area Dopamine DA VTA Neurons After obtaining a stable perforated patch recording, DA VTA neurons were identified in current-clamp rec[r] ...
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Acute Tramadol-Induced Cellular Tolerance and Dependence of Ventral Tegmental Area Dopaminergic Neurons: An In Vivo Electrophysiological Study
... Drug addiction is a major maladaption of the brain in human populations. It could even start by prescription of drugs. The Ventral Tegmental Area (VTA) Dopaminergic (DA) neurons are the core brain ...
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Volume and Connectivity of the Ventral Tegmental Area are Linked to Neurocognitive Signatures of Alzheimer's Disease in Humans
... colleagues found that, in a mouse model of the disease, very early anatomical changes are present in a subcortical brain region rich in dopaminergic neurons, the ventral tegmental area (VTA), or ...
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The interactive effects of ketamine and ethanol on dopamine expression in the ventral tegmental area of rats
... Methods: Here, we evaluated the effects of two different doses of ketamine (30 mg/kg and 60 mg/kg) with and without ethanol (0.3156 g/kg) on DA concentration in the rat’s ventral tegmental area ...
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Microinfusion of Bupropion Inhibits Putative GABAergic Neuronal Activity of the Ventral Tegmental Area
... Introduction: The most common interpretation for the mechanisms of antidepression is the increase of the brain monoamine levels such as dopamine (DA). The increase of DA can reduce depression but it can also decrease the ...
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<p>Role of Dopaminergic Receptors Within the Ventral Tegmental Area in Antinociception Induced by Chemical Stimulation of the Lateral Hypothalamus in an Animal Model of Orofacial Pain</p>
... rodent ventral tegmental area (VTA) contains both orexin recep- tors, orexin-1 (OX1) and orexin-2 (OX2) receptors 6,7 with particularly high levels of OX2 ...
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Otx2 expression is restricted to dopaminergic neurons of the ventral tegmental area in the adult brain
... the ventral tegmental area (VTA), the substantia nigra (SN) and the retrorubral field (RRF) and originate from progenitors located in the floor plate region of the anterior prosomeres and ...
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The Response of Ventral Tegmental Area Dopaminergic Neurons to Bupropion: Excitation or Inhibition?
... Introduction: Antidepressants can modulate brain monoamines by acting on pre-synaptic and postsynaptic receptors. Autoreceptors can reduce the monoamines effect on the somatodendritic or pre-synaptic regions despite its ...
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MORPHINE RELE ASES GLUTAMATE THROUGH AMPA RECEPTORS IN THE VENTRAL TEGMENTAL AREA: A MICRODIALYSIS STUDY IN CONSCIOUS RATS
... VTA is known to be involved in the mediation of a vari ety of behavioral responses. Glutamate is one of the neu rotransmitters in this area that plays an important role in addiction. Our results demonstrated ...
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Gabapentin regulates dopaminergic neuron firing and theta oscillation in the ventral tegmental area to reverse depression-like behavior in chronic neuropathic pain state
... Next, the depressive symptoms associated with chronic pain were examined. The mobility, anhedonia, and behavioral despair for depression were evaluated using OFT, SPT, and FST, respectively, to demonstrate ...
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Ventral Tegmental Area Neuronal Activity Correlates to Animals’ Behavioral Response to Chronic Methylphenidate Recorded from Adolescent SD Male Rats
... Methylphenidate (MPD) is considered as the first-line pharmacotherapy to treat ADHD. More re- cently, MPD has also been used as a cognitive enhancement recreationally. Its therapeutic effects are not fully understood, ...
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Effect of flavor on neuronal responses of the hypothalamus and ventral tegmental area
... In addition to reward effects, flavor might affect the neuronal activity of the hypothalamus as sweet taste without caloric intake has been shown to elicit an insulin response 22.. Howe[r] ...
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Local infusion of low, but not high, doses of alcohol into the anterior ventral tegmental area causes release of accumbal dopamine
... [28,29]). Previously, alcohol-induced reward, as meas- ured by alcohol-induced locomotor stimulation, accum- bal dopamine release, and alcohol intake were shown to be mediated via nicotinic acetylcholine receptors, espe- ...
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Opioid stimulation in the ventral tegmental area facilitates the onset of maternal behavior in rats
... An inverted V-shaped pattern of dose-responsiveness was obtained in which the effectiveness of MS was reduced as the dose increased, presumably as a result of an increas[r] ...
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