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Verapamil Hydrochloride

FORMULATION AND OPTIMIZATION OF VERAPAMIL HYDROCHLORIDE MICROCAPSULES

FORMULATION AND OPTIMIZATION OF VERAPAMIL HYDROCHLORIDE MICROCAPSULES

... Verapamil hydrochloride microcapsules prepared with sodium alginate, carbopol and magnesium start in different ratios of polymers with the drug by the iconic Gelation Technique and the prepared ...

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Simultaneous Determination of Verapamil Hydrochloride and Gliclazide in Synthetic Binary Mixture and Combined Tablet Preparation by Chemometric Assisted Spectroscopy

Simultaneous Determination of Verapamil Hydrochloride and Gliclazide in Synthetic Binary Mixture and Combined Tablet Preparation by Chemometric Assisted Spectroscopy

... A comparative study of the use of PLS-1 and PCR for the separation and simultaneous estimation of VER and GLZ in a binary mixture has been accomplished, showing that this method provide a clear example of the high ...

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Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period

Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period

... of verapamil - hydrochloride on the level of blood cells aggregation, given the location of the calcium channel in the structure of the NMDA - receptors of lymphocytes and which function is ...of ...

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Synthesis, Characterization and Drug delivery of Verapamil Hydrochloride loaded Montmorillonite Nanocomposite Beads

Synthesis, Characterization and Drug delivery of Verapamil Hydrochloride loaded Montmorillonite Nanocomposite Beads

... In the present research programme, Verapamil Hydrochloride loaded Sodium Alginate/Polyethylene oxide/Montmorillonite nanocomposite beads were prepared by using gelation method. Sodium alginate (SA) and Poly ...

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Stability indicating uplc method for determination of impurities in verapamil hydrochloride drug substance

Stability indicating uplc method for determination of impurities in verapamil hydrochloride drug substance

... Several LC methods with shorter run time and high throughput were tried for the separation of sixteen impurities along with verapamil hydrochloride. These includes different stationary phase, column ...

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FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF VERAPAMIL HYDROCHLORIDE

FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF VERAPAMIL HYDROCHLORIDE

... of verapamil hydrochloride were prepared by using HPMC K15M, Xanthan and Guar Gum polymers with different concentration in various batches of the formulations to facilitate the drug release which cause ...

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Effect Of Super Disintegrating Agent And Lubricant On Optimized Fast Disintegrating Tablets Of Verapamil Hydrochloride.

Effect Of Super Disintegrating Agent And Lubricant On Optimized Fast Disintegrating Tablets Of Verapamil Hydrochloride.

... of Verapamil hydrochloride which were prepared in order to achieve constant plasma concentrations, to improve the bioavailability by the avoidance of hepatic first-pass metabolism, and to prevent frequent ...

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DEVELOPMENT AND EVALUATION OF VERAPAMIL HYDROCHLORIDE XANTHAN GUM MICROCAPSULES AS CONTROLLED DRUG DELIVERY SYSTEM

DEVELOPMENT AND EVALUATION OF VERAPAMIL HYDROCHLORIDE XANTHAN GUM MICROCAPSULES AS CONTROLLED DRUG DELIVERY SYSTEM

... containing Verapamil hydrochloride xanthan complexes encoated with ethyl cellulose by emulsion solvent evaporation ...of Verapamil hydrochloride loaded microcapsules (VXM2) formulation was ...

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Title:  DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE TABLETS FOR HIGHLY  WATER SOLUBLE DRUG Author:  Smita R. Narnaware, Jayshree V. Patil, Shabnam Saher, Archana Bhuyar Keyword:  Sustained release tablet, Verapamil hydrochloride, Hydrocolloids, Carrra

Title: DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE TABLETS FOR HIGHLY WATER SOLUBLE DRUG Author: Smita R. Narnaware, Jayshree V. Patil, Shabnam Saher, Archana Bhuyar Keyword: Sustained release tablet, Verapamil hydrochloride, Hydrocolloids, Carrrageenan, ChitosanPage No: 49-56DOI: 10.30876/JOHR.7.2.2018.49-56Abstract: Sustained release tablets reduce the frequency of the dosing and increase the effectiveness of the drug by localization at the site of action, providing uniform drug delivery. Verapamil hydrochloride was considered as an ideal drug for designing sustained release formulation because of the high frequency of administration and short biological half-life. Therefore, in the present study, sustained release tablets of verapamil hydrochloride were prepared by using synthetic hydrocolloids like HPMC K4M, K15M, and K100M and using interaction of natural gums like carrrageenan and chitosan. Before using carrrageenan and chitosan an attempt was made to study the mechanism of interaction of carrageenan and chitosan by FT-IR spectroscopy, x-ray diffraction spectroscopy and differential scanning calorimetry. Then these prepared tablets were evaluated for various parameters such as hardness, friability, thickness, weight variation and the formulations were found to be within limits. The in vitro drug release profile of the various formulations was performed. In pH 1.2 buffer Peppas model was found to be the best fit model of drug release and a better control on drug release can be obtained by varying the proportion of HPMC K4M, K15M and K100M. Hence, it was concluded that the drug release can be effectively controlled for a highly water soluble drug verapamil HCI using synthetic hydrocolloids and interaction of natural gums carrageenan and chitosan. Keywords: Sustained release tablet, Verapamil hydrochloride, Hydrocolloids, Carrrageenan, Chitosan Download PDF

... of verapamil hydrochloride using synthetic gums like HPMC K4M, K15M and 100M and using interaction of natural gums like carrrageenan and chitosan for better control of drug ...

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FORMULATION AND EVALUATION OF BILAYER FLOATING TABLET CONTAINING VERAPAMIL HYDROCHLORIDE

FORMULATION AND EVALUATION OF BILAYER FLOATING TABLET CONTAINING VERAPAMIL HYDROCHLORIDE

... and or coronary artery diseases. The profile of verapamil hydrochloride indicates that it is a drug with short half life(3-6 hrs) and hence requires frequent dosing like 3-4 tablets daily. This frequent ...

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Enhanced Skin Permeation of Verapamil Hydrochloride Through Ethanolic Liposomes

Enhanced Skin Permeation of Verapamil Hydrochloride Through Ethanolic Liposomes

... of verapamil hydrochloride that could be incorporated into ethosomes was found to be 20mg with percentage entrapment efficiency of ...of verapamil hydrochloride in ethosomes may be due to the ...

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Design, Devolopment and Charecterization of Verapamil Hydrochloride Membrane Moderate Type Transdermal Patches

Design, Devolopment and Charecterization of Verapamil Hydrochloride Membrane Moderate Type Transdermal Patches

... evaluate Verapamil hydrochloride transdermal films and to study the effect of different formulation variables such as polymer concentration, polymer ratio, plasticizer concentration, permeation enhancer ...

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STABILITY STUDIES OF THE OPTIMIZED ORAL CONTROLLED RELEASE VERAPAMIL HYDROCHLORIDE TABLET FORMULATIONS

STABILITY STUDIES OF THE OPTIMIZED ORAL CONTROLLED RELEASE VERAPAMIL HYDROCHLORIDE TABLET FORMULATIONS

... The results of long term stability studies also confirmed the physical and chemical stability of formulations. Like accelerated studies, the results in long term studies were obtained with minor changes. In case of ...

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Design and development of polyethylene oxide based matrix tablets for verapamil hydrochloride

Design and development of polyethylene oxide based matrix tablets for verapamil hydrochloride

... of verapamil hydrochloride. Verapamil hydrochloride was formulated as oral controlled release matrix tablets by using the polyethylene oxides (Polyox WSR ...for verapamil ...

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FORMULATION AND CHARACTERIZATION OF MUCOADHESIVE MICROSPHERES USING VERAPAMIL HYDROCHLORIDE AS MODEL DRUG

FORMULATION AND CHARACTERIZATION OF MUCOADHESIVE MICROSPHERES USING VERAPAMIL HYDROCHLORIDE AS MODEL DRUG

... Verapamil hydrochloride is a water-soluble cardiovascular ...of verapamil hydrochloride into the aqueous phase during the curing of the gel ...

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Elastic liposomes mediated transdermal delivery of verapamil hydrochloride

Elastic liposomes mediated transdermal delivery of verapamil hydrochloride

... hydrochloride on oral administration undergoes extensive first pass metabolism which is responsible for its low bioavailability i.e. 20%. It has a short biological half life of just 4.8 hours, due to its short ...

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Novel gastroretentive mucoadhesive pulsatile tablet for Verapamil hydrochloride

Novel gastroretentive mucoadhesive pulsatile tablet for Verapamil hydrochloride

... Core tablets containing verapamil hydrochloride were press coated with different ratios of HPMC E15 and Carbopol 974P in two steps. First required amounts of HPMC and carbopol were weighed and mixed ...

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Enhanced Skin Permeation of Verapamil Hydrochloride ThroughEthanolic Liposomes

Enhanced Skin Permeation of Verapamil Hydrochloride ThroughEthanolic Liposomes

... of verapamil hydrochloride that could be incorporated into ethosomes was found to be 20mg with percentage entrapment efficiency of ...of verapamil hydrochloride in ethosomes may be due to the ...

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Spectrophotometric Determination of Verapamil Hydrochloride using Bromokresol Green

Spectrophotometric Determination of Verapamil Hydrochloride using Bromokresol Green

... The solvent was chosen bearing in mind the solubility of verapamil hydrochloride and BKG, as well as the maximum yield of the reaction product, i. e., the maximum value of optical density. The amount of ...

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Formulation and evaluation of transdermal drug delivery system of verapamil hydrochloride

Formulation and evaluation of transdermal drug delivery system of verapamil hydrochloride

... In this research, attempts were made to formulate Verapamil Hydrochloride patches has been developed for the sustain transport of the drug action. This is done by using HPMC, CAP and EC as the rate ...

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