Viral interference with IFN induction processes
Studies on interferon (IFN) induction and isolation of IFN inducing mutant viruses
... from viral antigens free of viral nucleic acid, and contain only a small portion of the viral protein, rather than the whole ...no viral genomic RNA, there is no chance of causing a ...
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The Resolution Phase of NK Cell Proliferation and IFN Production Following Viral Infection Are Highly Regulated Processes.
... suppress viral-induced NK cell proliferation in our AT system, we proceeded to evaluate a number of candidate molecules using enriched T cells from gene-targeted mice, including T cells from mice deficient in ...
151
A Rhesus Rhadinovirus Viral Interferon (IFN) Regulatory Factor Is Virion Associated and Inhibits the Early IFN Antiviral Response
... I IFN induction by specif- ically blocking the phosphorylation and nuclear accumulation of IRF7 ...hampered IFN-  transcription very soon after poly(I · C) transfection, this led to our ...
15
TRAM is required for TLR2 endosomal signaling to type I IFN induction
... impaired induction of type I IFN, indicating a role for TRAM in this TLR2-dependent pathway, while Staphylococcus aureus stimulated IFN-β was also ...I IFN induction in response to both ...
29
Alpha/Beta Interferon (IFN-α/β)-Independent Induction of IFN-λ1 (Interleukin-29) in Response to Hantaan Virus Infection
... for IFN- (20, 32), it might be that some, if not all, of the secreted IFN- is con- sumed by the cells, thus decreasing the amount of free IFN- in supernatants to levels undetectable by ...
9
Comparison of viral replication and IFN response in alpaca and bovine cells following bovine viral diarrhea virus infection
... greater IFN expression in AT cells acting to inhibit BVDV ...I IFN with no signi ficant difference in IFN induction between alpaca and bovine cells following infection, which corresponds to ...
7
Alpha/Beta Interferon (IFN-α/β) Signaling in Astrocytes Mediates Protection against Viral Encephalomyelitis and Regulates IFN-γ-Dependent Responses
... induce IFN- in microglia/macrophages ...of IFN- ␣/ are essential to prevent viral dissemination and mortality (31, ...the IFN- ␣/ pathway in astrocytes and microglia isolated from naive and ...
20
NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3
... the interference with SFSV NSs at a late stage in the signaling pathway on the one hand and the domain mapping on the other hand, a mechanism involving the sequestration of the DBD by SFSV NSs from the IFN- ...
18
IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils
... non-CNS viral infectious models including the influenza virus and herpes simplex virus-1 infections, which attribute Th17 cell-mediated pathogenesis to neutrophil attraction ...EAE induction, while impaired ...
15
Role of IFN γ in induction of Foxp3 and conversion of CD4+ CD25– T cells to CD4+ Tregs
... in IFN-γ–deficient ...that IFN-γ is critically required for the conversion of CD4 + CD25 – T cells to CD4 + Tregs during ...in IFN-γ knockout mice was directly associated with altered ...
9
Spatial-Temporal Patterns of Viral Amplification and Interference Initiated by a Single Infected Cell
... physics. Viral gene expression, activation of innate defensive cytokine production, and stimulation of cell-me- diated adaptive immune responses combine with physical move- ment of virus particles and cytokines ...
15
Pro-inflammatory TNF-α and IFN-γ Promote Tumor Growth and Metastasis via Induction of MACC1
... including AP-1, Sp1, and C/EBPs, which were shown to regulate MACC1 expression ( 35 ). TNF-α mediates a variety of cell-signaling processes involved in the immune response and carcinogenesis, primarily via its ...
15
Viral RNA at Two Stages of Reovirus Infection Is Required for the Induction of Necroptosis
... of viral RNA are required for the induction of necroptosis, they are not ...that viral RNA interfaces with host components at two different stages of infection to induce ...the viral ...
19
Successful Interference with Cellular Immune Responses to Immunogenic Proteins Encoded by Recombinant Viral Vectors
... as, for instance, in muscular dystrophies, where even intracel- lular or nuclear transgene products may become cross-pre- sented due to excessive cell death (31). In the present study we demonstrate that, even if cross- ...
9
Reovirus Induction of and Sensitivity to Beta Interferon in Cardiac Myocyte Cultures Correlate with Induction of Myocarditis and Are Determined by Viral Core Proteins
... of viral RNA synthesis determines ...cytes, viral spread through primary cardiac myocyte cultures and the resulting cumulative cell death correlate with viral myocarditic ...increased ...
10
Influence of the Viral Regulatory Region on Tumor Induction by Simian Virus 40 in Hamsters
... Whether viral DNA replication is a prerequisite for the occurrence of such rear- rangements is unclear, but it has been proposed that recombi- nation occurs between two newly synthesized daughter strands during ...
9
Intrinsic Interference: a New Type of Viral Interference
... The steps taken to detect intrinsic interference in indi- vidual cells are listed below and will be referred to col- lectively as the intrinsic-interference test: (i) infection of cells [r] ...
10
Defective Influenza Viral Ribonucleoproteins Cause Interference
... ments (Table 1) show that peak I did not inter- fere with infectious virus, whereas peak III caused a 40 to 70% reduction as tested by infec- tious center assay (17).. RNase treatment ab[r] ...
6
CRISPR/Cas9 mediated viral interference in plants
... evolved viral variants. Engineered resistance of the plant host to viral infec- tion might place selection pressure on the virus, leading to generation of variants with better adaptation, ...targets ...
11
The role of a viral microRNA and RNA interference during viral replication in mammalian cells
... suggest viral miRNAs might make worthy anti-viral drug ...identifying viral-encoded miRNAs that does not require an experimental infectious ...
119