viral oncogene
Abrogation of the Brd4-Positive Transcription Elongation Factor b Complex by Papillomavirus E2 Protein Contributes to Viral Oncogene Repression
... repress viral E6/E7 onco- gene transcription, it is suggested that the binding of Brd4 and associated P-TEFb with viral chromatin is essential for inte- grated viral oncogene E6/E7 ...grated ...
12
V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis
... Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Fatality rates are substantial, and long-term sequelae develop in about half of survivors. Here, we have performed a prospective ...
11
HTLV-1 viral oncogene HBZ drives bone destruction in adult T cell leukemia
... HTLV-1 viral oncogenes Tax and HBZ have been shown to independently regulate expres- sion of cellular genes involved in osteoclast activation and ...of viral infection and subsequent oncogenic ...
17
Mutant Feline Sarcoma Proviruses Containing the Viral Oncogene (v-fes) and Either Feline or Murine Control Elements
... 3 Mutant Feline Sarcoma Proviruses Containing the Viral Oncogene v-fes and Either Feline or Murine Control Elements Received 23 September 1982/Accepted 8 December 1982 The sequences requ[r] ...
13
CCCTC binding factor recruitment to the early region of the human papillomavirus type 18 genome regulates viral oncogene expression
... stein-Barr virus (EBV) and Kaposi’s sarcoma-associated her- pesvirus (KSHV). Mutation of sites to prevent CTCF binding has demonstrated that CTCF determines latency in these viruses by blocking epigenetic silencing of ...
16
Subcellular localization of glycoproteins encoded by the viral oncogene v-fms.
... The selective detection at the cell surface of gp140"'s, the least predominant form of the glycoprotein in transformed cells, shows that the target- *^*ing of v-fms-coded molecules to th[r] ...
12
Determinants of Viral Oncogene E6 E7 mRNA Overexpression in a Population Based Large Sample of Women Infected by High Risk Human Papillomavirus Types
... In our study, HPV E6-E7 mRNA positivity among HPV DNA-positive women varied between centers and in relation to the HPV DNA assay used, with lower values in centers with higher HPV DNA positivity and vice versa. This ...
10
Expression of Kirsten murine sarcoma virus in transformed nonproducer and revertant NIH/3T3 cells: evidence for cell-mediated resistance to a viral oncogene in phenotypic reversion.
... All transformed nonproducer cells were found to express high levels of both viral RNA and p21 transforming protein at least 10- to 30-fold higher than endogenous mouse ras expression wit[r] ...
6
Comparative Analysis of V-Akt Murine Thymoma Viral Oncogene Homolog 3 (AKT3) Gene between Cow and Buffalo Reveals Substantial Differences for Mastitis
... We also identified the important consensus sequence motifs, variation in 2000 upstream of ATG, substantial difference in the “3 UTR” region, and miRNA association in the buffalo sequen[r] ...
14
Mechanisms of Human Papillomavirus E2-Mediated Repression of Viral Oncogene Expression and Cervical Cancer Cell Growth Inhibition
... The papillomavirus E2 gene product plays a pivotal role in viral replication. E2 has multiple functions, including (i) transcriptional activation and repression of viral promoters and (ii) the enhancement ...
9
CCCTC-Binding Factor Recruitment to the Early Region of the Human Papillomavirus 18 Genome Regulates Viral Oncogene Expression
... Identification of CTCF binding sites in alpha-HPV genomes by bioinformatic analysis. CTCF binding sites in the genomes of low-risk HPV types 6b and 11 and high-risk HPV types 16, 18, and 31 were predicted using open ...
16
The impact of the MYB-NFIB fusion proto-oncogene in vivo
... myelobastosis viral oncogene homolog (MYB) and nuclear factor I/B (NFIB) generates the MYB-NFIB transcription factor, which has been detected in a high percentage of individuals with adenoid cystic ...
8
The Human Papillomavirus Type 16 E7 Oncogene Is Required for the Productive Stage of the Viral Life Cycle
... The viral oncogene E7, in the context of the full episomal HPV-16 genome, extends the life span of ...episomal viral DNA, analysis of the colonies arising from transfections with the E7-deficient ...
10
ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming
... to malignant transformation. We previously showed that accumulation of the oncometabolite, 2-hydroxyglutarate (2HG), in breast tumors was associated with MYC signaling, but not with isocitrate dehydrogenase (IDH) ...
19
CUX2 functions as an oncogene in papillary thyroid cancer
... Meanwhile, we also assessed the mRNA expression levels of CUX2 in TC cell lines and found that CUX2 was consistently upregulated in KCT-1, TPC-1, BCPAP, and FTC-133 cells compared[r] ...
8
Nucleic acid sequences of the oncogene v-rel in reticuloendotheliosis virus strain T and its cellular homolog, the proto-oncogene c-rel.
... We have sequenced v-rel and its flanking sequences, each of the regions of the c-rel locus from turkey that are homologous to v-rel and their flanking sequences, and the coding sequence [r] ...
11
Oncogene addiction in gliomas: Implications for molecular targeted therapy
... determining oncogene addiction in ...screening oncogene addiction networks was ...defining oncogene addiction ...novel oncogene addiction networks based on the individual genomics of the ...
5
CD3-ε Overexpressed in Prothymocytes Acts as an Oncogene
... pressing functional CD3-s-derived proteins, but not in transgenic mice made with a genomic construct that did not have any protein expres- sion (sA2); (2) the frequency of tumor incidenc[r] ...
10
Temperature-sensitive transforming mutants of the v-rel oncogene.
... To determine whether ts v-Rel proteins isolated from spleen cells grown at the nonpermissive temperature for transformation could bind DNA in vitro, lysates were prepared from wild-type [r] ...
6
Transcriptional targeting of oncogene addiction in medullary thyroid cancer
... Treatment with the CDK7 inhibitor THZ1 mimicked the results seen with dinaciclib in terms of reduced cell viability and proliferation, apoptosis, CDK9 and RET mRNA and protein reductio[r] ...
21