Viral vector
Multivalent and Multipathogen Viral Vector Vaccines
... Coxsackievirus group B. Coxsackieviruses are positive-sense single-stranded RNA (ssRNA) viruses. Six serotypes of group B coxsackievirus (CVB1 to CVB6) have been described, of which CVB3 has been particularly identified ...
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Atraumatic Oral Spray Immunization with Replication-Deficient Viral Vector Vaccines
... by viral vector vaccines consists of a multilayer, nonkeratinized squa- mous ...replication-deficient viral vector vaccines after immunization by the tonsillar route and compared them * ...
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Evaluation of the role of innate lymphoid cells following viral vector vaccination
... Viral vector-based vaccine studies in our laboratory for the last decade have shown that IL-13 plays a crucial role in modulating the efficacy of a vaccine in a route dependent manner, where mucosal ...
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Expression and Purification of Human Interferon Gamma Using a Plant Viral Vector
... using viral vector for pharmaceutical protein expression in plant is an efficient and inexpensive recombinant protein production while minimizing the risk for contamination with endotoxins and maximizing ...
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An MRI-visible non-viral vector for targeted Bcl-2 siRNA delivery to neuroblastoma
... non-viral vector (scAb GD2 -PEG-g-PEI-SPION) and then with Bcl-2 siRNA to form nanoparticles showing low ...non-viral vector for targeted neuroblastoma siRNA therapy and ...
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Gallid herpesvirus 3 SB-1 strain as a recombinant viral vector for poultry vaccination
... In this paper we show that a GaHV3 (MDV-2) strain SB-1, already in use as a licensed vaccine against MD since the mid-1980s, can be used as a viral vector expressing the IBDV VP2 capsid antigen to induce ...
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A Narcissus mosaic viral vector system for protein expression and flavonoid production
... a viral particle ...NMV viral system has the potential to produce high level proteins, given the material used for protein measurement only had local infection foci (Additional file 1: Figure S1) on the ...
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Changing Viral Tropism Using Immunoliposomes Alters the Stability of Gene Expression: Implications for Viral Vector Design
... In this report, we describe an alterna- tive targeting strategy using immunovi- rosomes generated by mixing mildly aggregated monoclonal antibodies, lipo- somes, and viral particles. This strategy is based on the ...
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Foxtail mosaic virus: a new viral vector for protein expression in cereals
... expression vector. A: FoMV genome organisation and expression strategy. The viral genomic RNA (gRNA) contains five major open reading frames (ORFs; labelled from 1 to 4, and CP), coding for the polymerase ...
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Adeno-Associated Viral Vector-Driven Expression of Coagulation Proteins for Treatment of Hemophilias and Cancer
... that vector doses for HB can be dramatically lowered with no loss of FIX activity by utilizing the naturally occurring, hyper-functional FIX-Padua as the transgene, potentially allowing for vector doses low ...
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Synthesis and properties of a novel biodegradable poly(ester amine) copolymer based on poly(L-lactide) and low molecular weight polyethylenimine for gene delivery
... A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity. [r] ...
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Overcoming Immunity to a Viral Vaccine by DNA Priming before Vector Boosting
... ADV-GP(Z) priming and boosting regimen in contrast to DNA prim- ing and viral vector boosting. (A) The Ebola virus GP-specific CTL response was evaluated as described in the legend for Fig. 1A. Each symbol ...
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2.11 and 2.112 biotech.ppt
... White blood cells were removed and normal copies of the defective gene were inserted. using a viral vector.[r] ...
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Zhang, Wenli (2012): Adenovirus-based gene therapy approaches for hemophilia B. Dissertation, LMU München: Medizinische Fakultät
... the viral vector constructs and location of real-time PCR ...transposon-donor vector, expressing canine coagulation factor IX under control of the liver specific human alpha-1-antitrypsin promoter ...
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Müller, Katharina (2018): Characterization of Vaccinia virus MVA candidate vaccines mutated in viral genes modulating inflammasome activation. Dissertation, LMU München: Tierärztliche Fakultät
... Prophylactic vaccines against various pathogens are generally very effective and protect against all types of infectious diseases. Therapeutic cancer vaccines on the other hand are much less successful. One reason for ...
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An Update on New Vaccines for Tuberculosis
... The viral vector is also used to develop new TB vaccine, for example, the modified vaccinia virus Ankara 85A (MVA85A) which utilizes poxvirus to express Ag85A while Aeras 402 uses a recombinant ...
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In Vivo Gene Transfer Using a Nonprimate Lentiviral Vector Pseudotyped with Ross River Virus Glycoproteins
... increase vector MOI for hepatocytes, including catheter directed delivery to the hepatic artery or vein or direct portal vein injection of the vector ...lentiviral vector preparations, this assay ...
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Influence of E1-Deleted Recombinant Adenoviruses on B7.1 and IL-2 Expression in C1498 Cells
... of viral vector without significant expression of p53 in the ...of viral vector could be addressed to the presence of vector in the ...as viral vectors to deliver therapeutic ...
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Novel CHM mutations in Polish patients with choroideremia – an orphan disease with close perspective of treatment
... Mutation-independent therapies have not been trialled in CHM, but several clinical trials of retinal gene re- placement therapy are in progress [30]. Recently, the 24-month results of two clinical trials in male patients ...
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Development of a gene silencing DNA vector derived from a broad host range geminivirus
... plasmid vector or the recombined and released BCTV viral vector, DNA was extracted from bleached leaves of pWSRi:rbcS treated plants which were not yet present at the time of ...released viral ...
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