Virus Clearance
Interleukin-4 causes delayed virus clearance in influenza virus-infected mice.
... influenza virus infection in ...PR8 virus-infected mice, IL-4 treatment of cells was associated with the loss of the virus clearing activity seen after adoptive transfer of cells restimulated in the ...
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Overexpression of interleukin-4 delays virus clearance in mice infected with respiratory syncytial virus.
... syncytial virus (RSV) disease, its role in mediating the immune response to primary RSV infection remains ...eliminated virus from the lung as quickly as did C57BL/6 ...delayed virus clearance ...
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Alternative Mechanisms of Respiratory Syncytial Virus Clearance in Perforin Knockout Mice Lead to Enhanced Disease
... mice. Virus clearance was slightly delayed on days 6 and 8 but was accomplished by day 10 in both PKO and WT mice, suggesting that perforin-mediated lysis was not nec- essary for viral ...RSV ...
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Interleukin-10 Modulation of Virus Clearance and Disease in Mice with Alphaviral Encephalomyelitis
... Sindbis virus (SINV), the prototypical alphavirus, is the most widespread alphavirus and causes rash and arthritis in humans ...on virus and host factors, including host age and genetic background and ...
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Virus Clearance through Apoptosis-Dependent Phagocytosis of Influenza A Virus-Infected Cells by Macrophages
... influenza virus-infected HeLa cells are phagocytosed by macrophages and that the phagocytosis depends on the occurrence of apo- ...of virus growth, suggest- ing that the virus, together with its host ...
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Simian Immunodeficiency Virus Infection of Rhesus Macaques Results in Delayed Zika Virus Clearance
... ZIKV infection assessment in LN cells. Lymph node cells from day 5 and day 27 post-ZIKV infection were sorted into T cell, B cell, and macrophage populations (Fig. S2) for assessment of ZIKV viral RNA via qRT-PCR. RNA ...
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Surfactant protein A enhances respiratory syncytial virus clearance in vivo
... Bronchoalveolar lavage. Lung cells were recovered by bron- choalveolar lavage (BAL). Animals were sacrificed as described for viral clearance, and lungs were lavaged three times with 1 ml of sterile PBS. The fluid ...
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Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo.
... * t This 682 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Our data show that 1 x 107 to 1.5 x 107 lymphocytic choriomeningitis virus-specific, H-2-restricted cloned [r] ...
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Enhanced Virus Clearance by Early Inducible Lymphocytic Choriomeningitis Virus-Neutralizing Antibodies in Immunoglobulin-Transgenic Mice
... infection because LCMV-specific CTLs were exhausted (17, 29) (Fig. 6A). If 200 mg of the LCMV-neutralizing IgG1 MAb KL25 was administered intraperitoneally 4 h before i.c. virus challenge, mice died after low and ...
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Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus and in vitro properties.
... Analysis of the relationship between interferon release by cloned CTLs and their ability to lyse virus infected targets showed that interferon was made only by CTL clones reacted with th[r] ...
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Alphavirus-Induced Encephalomyelitis: Antibody-Secreting Cells and Viral Clearance from the Nervous System
... Production of SINV-specific Abs in peripheral lymphoid tissue. ASCs are generated in secondary lymphoid tissue in two phases: an early extrafollicular response that produces primar- ily low-affinity IgM and a later, ...
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The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection
... of virus clearance determines the duration of IFNβ expression in infiltrating Gr1 + CD11b + ...When virus replication was suppressed by Oseltamivir, body weight and influx of CCR2+ inflam- matory ...
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Vaccine Induced Measles Virus Specific T Cells Do Not Prevent Infection or Disease but Facilitate Subsequent Clearance of Viral RNA
... IMPORTANCE The components of vaccine-induced immunity necessary for protection from infection and disease have not been clearly identified for most vaccines. Vaccine development usually focuses on induction of antibody, ...
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Longitudinal Analysis of Feline Leukemia Virus-Specific Cytotoxic T Lymphocytes: Correlation with Recovery from Infection
... of virus- specific cytolysis were observed earlier in cats which recovered following challenge compared to cats which became persis- tently ...infectious virus from the blood in the absence of detectable ...
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Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification
... To obtain cell suspensions for flow cytometric analyses and stimulation cultures, the spleens, livers and CNS were harvested from mice after an intracardiac perfusion with a 0.9% saline solution to remove the ...
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Cancer Cells Impair the Clearance of Oncolytic Virus M1 by Macrophage in a Non-Contact-Dependent Manner
... M1 virus from macrophages perspective other than tumor cells and finally increase the response rate of M1 in future clinical ...M1 virus replication, indicating that 15- PGDH may function as an antiviral ...
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Clearance of lymphocytic choriomeningitis virus in antibody- and B-cell-deprived mice.
... In organs of IL-suppressed BALB/c mice, LCMV-WE replicated, dependent upon organ, at the same rate or more rapidly and, in general, to higher titers than in normal rabbit immunoglobulin-[r] ...
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How to Clear HBV cccDNA: CRISPR/Cas9 Might Be Promising
... First, the efficiency of CRISPR/Cas9 system is low needing to be improved. In some studies [13, 50], serum HBsAg level was reduced but persisted following the CRISPR/Cas9 therapy, potentially leading to rebound viremia ...
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Brain-infiltrating cytolytic T lymphocytes specific for Theiler's virus recognize H2Db molecules complexed with a viral VP2 peptide lacking a consensus anchor residue.
... infection. The latter, TMEV-susceptible mouse strains, de- velop a chronic, progressive form of demyelination similar both clinically and pathologically to human multiple sclerosis (MS). TMEV-infected mice provide an ...
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PubMedCentral-PMC5597584.pdf
... immunity. Clearance of measles virus (MeV) involves rapid elimination of infectious virus during the rash followed by slow elimination of viral ...
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