virus-like particle
An Intranasal Virus Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus
... B virus (IBV) strains (11) but require a close antigenic match with circulating ...demic virus emergence complicates vaccination strategies even further (12, ...Various virus-like ...
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Electrostatic Interactions between Hendra Virus Matrix Proteins Are Required for Efficient Virus-Like-Particle Assembly
... parainfluenza virus type 1 (hPIV1) (35), Sendai virus (40), Nipah virus (32), measles virus (37), and Newcastle disease virus (NDV) (36), the expression of M proteins alone is sufficient ...
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Nipah Virus-Like Particle Egress Is Modulated by Cytoskeletal and Vesicular Trafficking Pathways: a Validated Particle Proteomics Analysis
... Nipah virus budding is significantly modulated upon the inhibition of endocytosis, recycling, and ESCRT ...and virus-like particle (VLP) fractions were prepared 24 h after transfection and used ...
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Enhanced Influenza Virus-Like Particle Vaccines Containing the Extracellular Domain of Matrix Protein 2 and a Toll-Like Receptor Ligand
... lethal virus challenge (8, 10, 15, 16, 39, ...based virus-like particle (VLP) antigen was used as a supplement to inactivated viral vaccines ...
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Hepatitis C Virus-Like Particle Morphogenesis
... sequence, virus-like particle assembly may in this case involve the region of the HCV RNA encoding the core, which is believed to be involved in encapsidation ...
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Virus-Like Particle Secretion and Genotype-Dependent Immunogenicity of Dengue Virus Serotype 2 DNA Vaccine
... Dengue virus (DENV), composed of four distinct serotypes, is the most important and rapidly emerging arthropod-borne patho- gen and imposes substantial economic and public health ...dengue virus serotype 2 ...
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Murine Immune Responses to Virus-Like Particle-Associated Pre- and Postfusion Forms of the Respiratory Syncytial Virus F Protein
... RSV virus-like particle that stimulates protective immune responses in mice (26, ...disease virus (NDV) and the ectodomains of the RSV F and G proteins fused to the transmembrane (TM) and ...
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A Single Intramuscular Dose of a Plant-Made Virus-Like Particle Vaccine Elicits a Balanced Humoral and Cellular Response and Protects Young and Aged Mice from Influenza H1N1 Virus Challenge despite a Modest/Absent Humoral Response
... ABSTRACT Virus-like-particle (VLP) influenza vaccines can be given intramuscularly (i.m.) or intranasally (i.n.) and may have advantages over split-virion formulations in the elderly. We tested a ...
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A Disulfide-Bonded Dimer of the Core Protein of Hepatitis C Virus Is Important for Virus-Like Particle Production
... C virus (HCV) core protein forms the nucleocapsid of the HCV ...HCV particle is assembled is not well ...nucleocapsid-like particle of HCV is composed of a disulfide-bonded core protein ...
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Prime-pull vaccination with a plant-derived virus-like particle influenza vaccine elicits a broad immune response and protects aged mice from death and frailty after challenge
... MN: Microneutralization; NA: Neuraminidase; ng: nanogram; NK: Natural killer cell; nm: nanometer; OD: Optical density; PBS: Phosphate-buffered saline; Pdm H1N1: Pandemic H1N1; PE: Phycoerythrin; PerCP: Peridinin ...
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Development of Virus-Like-Particle Vaccine and Reporter Assay for Zika Virus
... Zika virus (ZIKV) infection and the lack of an approved vaccine raise serious concerns regarding preparedness to combat this emerging ...a virus-like particle (VLP)-based approach to develop a ...
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Virus-Like Particle Vaccine Induces Protective Immunity against Homologous and Heterologous Strains of Influenza Virus
... influenza virus- like particles of higher ...influenza virus particles with spikes on their surfaces, characteristic of influenza virus HA proteins on viri- ...The particle sizes ranged ...
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Nontransmissible Virus-Like Particle Formation by F-Deficient Sendai Virus Is Temperature Sensitive and Reduced by Mutations in M and HN Proteins
... Sendai virus (SeV) is an enveloped virus with a nonseg- mented negative-strand RNA genome and is a member of the family ...three virus-derived proteins nucleoprotein (NP), phosphoprotein (P), and ...
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Reversible Binding of Recombinant Human Immunodeficiency Virus Type 1 Gag Protein to Nucleic Acids in Virus-Like Particle Assembly In Vitro
... deficiency virus type 1 (HIV-1) Gag protein used in all exper- iments was produced in Escherichia coli and lacks the p6 do- main present in authentic HIV-1 Gag ...
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Norwalk Virus-Like Particle Hemagglutination by Binding to H Histo-Blood Group Antigens
... Without a cell culture system for NV, there is no means to directly determine if H or Lewis antigen binding plays a part in NV infection. An association between expression of the B antigen and resistance to NV infection ...
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Bacterial superglue enables easy development of efficient virus-like particle based vaccines
... per particle varied according to antigen and the VLP employed, but the mean display capacity was 118 antigen molecules per spy-VLP, corresponding to that antigens had been coupled to 65 % of the available VLP ...
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Mutations in the Transmembrane Domain and Cytoplasmic Tail of Hendra Virus Fusion Protein Disrupt Virus-Like-Particle Assembly
... influenza virus, measles virus, and Sendai virus can all be found in Rab11-positive vesicles (29, 31, ...syncytial virus is facilitated by Rab11a-enriched apical recycling endosomes (34, 50), ...
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Enhanced Influenza Virus-Like Particle Vaccination with a Structurally Optimized RIG-I Agonist as Adjuvant
... M8 potentiates DC maturation and antiviral signaling in hu- man MDDC. The most efficient antigen-presenting cells are ma- ture, immunologically competent dendritic cells (DC) (32), and it is now accepted that the ...
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Analytical technologies for influenza virus like particle candidate vaccines: challenges and emerging approaches
... influenza virus; A/PR/8/1934 had 4 times the amount of NA activ- ity of VLPs, which agrees with the levels from the HA assay of Sf9 VLPs ...influenza virus [59]. Considering that in Nayak et al’s study the ...
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Recombinant norovirus specific scFv inhibit virus like particle binding to cellular ligands
... Therapeutic antibodies have been used successfully in treatment regimens for diseases including cancer and rheumatoid arthritis, for transplant rejection, and against respiratory syncytial virus infections in ...
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