Virus-like particle (VLP)
An Intranasal Virus Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus
... B virus (IBV) strains (11) but require a close antigenic match with circulating ...demic virus emergence complicates vaccination strategies even further (12, ...Various virus-like ...
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Nipah Virus-Like Particle Egress Is Modulated by Cytoskeletal and Vesicular Trafficking Pathways: a Validated Particle Proteomics Analysis
... Nipah virus budding is significantly modulated upon the inhibition of endocytosis, recycling, and ESCRT ...and virus-like particle (VLP) fractions were prepared 24 h after transfection and used ...
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A Single Intramuscular Dose of a Plant-Made Virus-Like Particle Vaccine Elicits a Balanced Humoral and Cellular Response and Protects Young and Aged Mice from Influenza H1N1 Virus Challenge despite a Modest/Absent Humoral Response
... ABSTRACT Virus-like-particle (VLP) influenza vaccines can be given intramuscularly (i.m.) or intranasally (i.n.) and may have advantages over split-virion formulations in the elderly. We tested a ...
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Prime-pull vaccination with a plant-derived virus-like particle influenza vaccine elicits a broad immune response and protects aged mice from death and frailty after challenge
... highly-successful virus-like particle (VLP) vac- cines are in current use (eg: HBV and HPV vaccines) and VLP vaccines have many potential advantages for a wide range of targets ...
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Electrostatic Interactions between Hendra Virus Matrix Proteins Are Required for Efficient Virus-Like-Particle Assembly
... Hendra virus (HeV) is a zoonotic paramyxovirus belonging to the genus ...disease virus (NDV) M and is fundamental to protein stability and effective virus-like- particle (VLP) ...
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Development of Virus-Like-Particle Vaccine and Reporter Assay for Zika Virus
... Zika virus (ZIKV) infection and the lack of an approved vaccine raise serious concerns regarding preparedness to combat this emerging ...a virus-like particle (VLP)-based approach to develop a ...
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Enhanced Influenza Virus-Like Particle Vaccines Containing the Extracellular Domain of Matrix Protein 2 and a Toll-Like Receptor Ligand
... lethal virus challenge (8, 10, 15, 16, 39, ...based virus-like particle (VLP) antigen was used as a supplement to inactivated viral vaccines ...
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Virus-Like Particle Secretion and Genotype-Dependent Immunogenicity of Dengue Virus Serotype 2 DNA Vaccine
... Dengue virus (DENV), composed of four distinct serotypes, is the most important and rapidly emerging arthropod-borne patho- gen and imposes substantial economic and public health ...dengue virus serotype 2 ...
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A Disulfide-Bonded Dimer of the Core Protein of Hepatitis C Virus Is Important for Virus-Like Particle Production
... C virus (HCV) core protein forms the nucleocapsid of the HCV ...HCV particle is assembled is not well ...nucleocapsid-like particle of HCV is composed of a disulfide-bonded core protein ...
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Murine Immune Responses to Virus-Like Particle-Associated Pre- and Postfusion Forms of the Respiratory Syncytial Virus F Protein
... RSV virus-like particle that stimulates protective immune responses in mice (26, ...disease virus (NDV) and the ectodomains of the RSV F and G proteins fused to the transmembrane (TM) and ...
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Hepatitis C Virus-Like Particle Morphogenesis
... sequence, virus-like particle assembly may in this case involve the region of the HCV RNA encoding the core, which is believed to be involved in encapsidation ...
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Virus-Like Particle Vaccine Induces Protective Immunity against Homologous and Heterologous Strains of Influenza Virus
... influenza virus- like particles of higher ...influenza virus particles with spikes on their surfaces, characteristic of influenza virus HA proteins on viri- ...The particle sizes ranged ...
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Gag Localization and Virus-Like Particle Release Mediated by the Matrix Domain of Human T-Lymphotropic Virus Type 1 Gag Are Less Dependent on Phosphatidylinositol-(4,5)-Bisphosphate than Those Mediated by the Matrix Domain of HIV-1 Gag
... Relative virus release efficiency was calculated as the amount of virus-associated Gag as a fraction of total Gag synthesized and nor- malized to the virus release efficiency in 5ptaseIV ⌬ ...
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Genotype Considerations for Virus-Like Particle-Based Bivalent Norovirus Vaccine Composition
... Norovirus (NoV) genogroup I (GI) and GII are responsible for most human infections with NoV. Because of the high genetic variability of NoV, natural infection does not induce sufficient protective immunity to different ...
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Real-time monitoring for the enhancement of virus-like particle recovery from yeast
... Only particulate contaminants (mainly cell debris) scatter light and so soluble contaminants (e.g. carbohydrates, soluble protein) do not contribute to the light scattering signal. To measure VLP in the presence of ...
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A Leucine Residue in the C Terminus of Human Parainfluenza Virus Type 3 Matrix Protein Is Essential for Efficient Virus-Like Particle and Virion Release
... for virus growth, and a mutant PIV5 with a P-to-A mutation in its FPIV L domain replicated very poorly and read- ily gave rise to second-site revertants that restored the budding function ...
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Norwalk Virus-Like Particle Hemagglutination by Binding to H Histo-Blood Group Antigens
... Noroviruses are a major cause of epidemic acute nonbacterial gastroenteritis worldwide. Here we report our discovery that recombinant Norwalk virus virus-like particles (rNV VLPs) agglutinate red ...
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Development of a Novel Virus-Like Particle Vaccine Platform That Mimics the Immature Form of Alphavirus
... ABSTRACT Virus-like particles (VLPs) are noninfectious multiprotein structures that are engineered to self-assemble from viral structural ...the virus, we altered our VLP’s in vivo dynamics and ...
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Enhanced Influenza Virus-Like Particle Vaccination with a Structurally Optimized RIG-I Agonist as Adjuvant
... M8 stimulates long-term immune responses. The same im- munization schedule was used to determine whether VLP vaccine adjuvanted with M8, alum, AddaVax, or poly(I·C) induced a long- term memory response against influenza ...
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Mutations in the Transmembrane Domain and Cytoplasmic Tail of Hendra Virus Fusion Protein Disrupt Virus-Like-Particle Assembly
... Endocytic trafficking of HeV F protein is required for proper assembly with M. In contrast to other paramyxovirus F proteins, henipavirus F proteins reach the cell surface in the inactive, uncleaved form. The proteins are ...
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