Virus-specific T cells
Vaccine Induced Measles Virus Specific T Cells Do Not Prevent Infection or Disease but Facilitate Subsequent Clearance of Viral RNA
... MeV-specific T-cell responses after challenge with wild-type MeV. Shown are T-cell responses 7 (A), 14 (B), and 35 (C) days after challenge as assessed by IFN- ␥ ...spot-forming cells (SFCs) ...
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A Fusion Inhibitor Prevents Spread of Immunodeficiency Viruses, but Not Activation of Virus-Specific T Cells, by Dendritic Cells
... Tween 20, 0.45% Igepal-630; all from Sigma Chemicals, St. Louis, MO) with 1 mg/ml proteinase K (Roche Biochemicals, Indianapolis, IN). Cell lysis was car- ried out for 90 min at 56°C, and proteinase K was inactivated by ...
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Increased Expression of the NK Cell Receptor KLRG1 by Virus-Specific CD8 T Cells during Persistent Antigen Stimulation
... by virus-specific CD8 T cells in hu- ...of virus-specific T cells were stained by the indicated tetram- ers (A2/pp65 for CMV, B8/Nef for HIV, B8/BZLF1 for EBV, and ...
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Regulation of Cytokine Production by Virus-Specific CD8 T Cells in the Lungs
... of virus-spe- cific memory T cells to produce cytokines after entry into the lung could be due to active suppression or to a lack of optimal ...stimulate virus-specific T ...by ...
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Antiviral antibodies attenuate T-cell-mediated immunopathology following acute lymphocytic choriomeningitis virus infection.
... Specific T lymphocytes are able to mediate a more rapid clearance of virus in transient asymptomatic infections 10, 20, 22, 40, and transfer of virus-specific T cells early after infecti[r] ...
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Sustained High Frequencies of Specific CD4 T Cells Restricted to a Single Persistent Virus
... of virus-specific CD4 T cells has already been demonstrated in elegant murine models, where frequencies of virus-specific CD4 T cells are stable even upon infection ...
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Early Interferon Therapy for Hepatitis C Virus Infection Rescues Polyfunctional, Long-Lived CD8+ Memory T Cells
... the cells demonstrated weak proliferative capacity against the NS3-1073 peptide during the early time points of the infection and diminished proliferation over time ...of virus-specific T ...
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Virus-Specific and Bystander CD8 T Cells Recruited during Virus-Induced Encephalomyelitis
... restricted T-cell entry into the naı¨ve CNS, viral infection induces vigorous T-cell responses (14, 18, ...of virus-specific versus “ir- relevant” bystander CD8 ⫹ T-cell recruitment and ...
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Development of virus specific CD4+ T cells during primary cytomegalovirus infection
... Although virus-specific CD4 + T cells have been characterized extensively in latently infected individuals, it is unclear how these protective T-cell responses develop during primary ...
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CD127+CCR5+CD38+++ CD4+ Th1 Effector Cells Are an Early Component of the Primary Immune Response to Vaccinia Virus and Precede Development of Interleukin-2+ Memory CD4+ T Cells
... ⫹ T cells that expressed IL-7R and produced IL-2 at day ...effector cells are precur- sors for memory cells which re-express high levels of Bcl-2 ...memory cells from apoptosis, ...
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Cross-Reactivity between Hepatitis C Virus and Influenza A Virus Determinant-Specific Cytotoxic T Cells
... C1R-AAD cells and 10 g of peptide per ...of specific spots was determined by subtracting the number of spots in the absence of antigen from the number of spots in the presence of ...10 specific ...
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Large scale analysis of pediatric antiviral CD8+ T cell populations reveals sustained, functional and mature responses
... CD8+ T cells in pediatric popula- ...CD8+ T cell response to HCMV was observed in specific cases of infec- tion of fetuses and newborns ...CD4+ T cell help, regulation, dendritic ...
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T Cells with a CD4+CD25+ Regulatory Phenotype Suppress In Vitro Proliferation of Virus-Specific CD8+ T Cells during Chronic Hepatitis C Virus Infection
... Treg cells to CD4-depleted PBMC markedly impaired the expan- sion of HCV-specific CD8 ⫹ T cells after 7 days in vitro peptide specific ...enhanced virus- specific CD8 ⫹ ...
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Progressive Loss of Memory T Cell Potential and Commitment to Exhaustion during Chronic Viral Infection
... antiviral T cell responses (31, ...C virus (HCV) infection (12, 16, 34), though the impact on preservation of T cell immunity in these cases is not always ...of virus-specific CD8 ...
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Comparisons of CD8+ T Cells Specific for Human Immunodeficiency Virus, Hepatitis C Virus, and Cytomegalovirus Reveal Differences in Frequency, Immunodominance, Phenotype, and Interleukin-2 Responsiveness
... Epstein-Barr virus (EBV)-transformed B cells were pulsed with the relevant peptide/pool at a concentration of ...presenting cells (APC) at an E:T ratio of ...⫹ T cells, CMV ...
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Increased Protein Degradation Improves Influenza Virus Nucleoprotein-Specific CD8+ T Cell Activation In Vitro but Not in C57BL/6 Mice
... influenza virus- specific CD8 ⴙ T cells are directed mainly against relatively conserved internal proteins, like nucleoprotein (NP), they are highly cross-reactive and afford protection ...
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MAVS Expressed by Hematopoietic Cells Is Critical for Control of West Nile Virus Infection and Pathogenesis
... memory virus-specific CD8 T cells could protect Mavs ⫺/⫺ mice, we performed a prime-boost vaccination strategy, immunizing mice with DCs coated with NS4B peptide, followed by boosting at day 7 ...
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Rotavirus-specific protein synthesis is not necessary for recognition of infected cells by virus-specific cytotoxic T lymphocytes.
... whether RRV was processed by target cells exposed to a protein synthesis inhibitor for recognition by RRV-specific CTLs, B6/WT-3 cells were both infected with RRV and labeled with 51Cr i[r] ...
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Analysis of the human T-cell response to picornaviruses: identification of T-cell epitopes close to B-cell epitopes in poliovirus.
... Twenty-nine individuals responded to poliovirus type 3, coxsackievirus B3, and encephalomyocarditis virus by proliferation of T cells, and from such cultures, 130 virus-specific T-cell l[r] ...
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Virus-Specific Deoxyribonucleic Acid in Simian Virus 40-Exposed Hamster Cells: Correlation with S and T Antigens
... 199-207 Copyright @ 1970 American Society for Microbiology Virus-Specific Deoxyribonucleic Acid in Simian Virus 40-Exposed Hamster Cells: Correlation with S and T Antigens1 Received for [r] ...
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