vitamin D receptor
Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1,25 dihydroxyvitamin D3
... We have identified and characterized two mutations in the hormone binding domain of the vitamin D receptor (VDR) in patients with hereditary vitamin D-resistant rickets. One patient was ...
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Vitamin D receptor gene polymorphisms and cardio-metabolic profile in women with hypovitaminosis D
... of vitamin D receptor (VDR) variants in determining cardiovascular risk factors has been suggested ...of vitamin D receptor (VDR) gene with metabolic profile in Iranian ...
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The Distribution of Vitamin D Receptor Genotypes and Haplotypes in Southern Moroccan Population
... Vitamin D functions are mediated through the vitamin D receptor (VDR), a nuclear transcription factor with a DNA-binding domain belonging to the nuclear hormone receptor ...X ...
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Association of Vitamin D Receptor (VDR) Start Codon FokI Polymorphism with Acute Myelogenous Leukemia
... The vitamin D receptor (VDR) has a thymine/cytosine (T/C) polymorphism located in the first of two potential start (ATG) codons, that can be detected by a restriction fragment length polymorphism ...
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Original Article Cutaneous expression of TREM, vitamin D receptor and HMGB1 in vitamin D deficiency
... the vitamin D receptor (VDR) and the triggering receptor expressed on myeloid cells (TREM) have been independently implicated in the biology of numerous of cutaneous ...of vitamin ...
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The association of vitamin D receptor gene polymorphisms and acute myeloid leukemia: a case-control study
... of vitamin D, 1, 25-dihydroxy vitamin D or cholecalciferol, acts by adjoining to its nuclear receptor in target cells (vitamin D ...The vitamin D ...
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Gene Polymorphism of Vitamin D Receptor (VDR) in Iraqi Population
... of vitamin D are exerted by binding to its intracellular receptor known as Vitamin D receptor (VDR) ...[2].Vitamin D-Vitamin D receptor complex ...
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Metabolic and cellular analysis of alopecia in vitamin D receptor knockout mice
... the vitamin D receptor (VDR) results in hypocalcemia, hypophosphatemia, hyper- parathyroidism, rickets, osteomalacia, and alopecia — the last a consequence of defective anagen initi- ...
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Associations of vitamin D deficiency and vitamin D receptor (Cdx-2, Fok I, Bsm I and Taq I) polymorphisms with the risk of primary open-angle glaucoma
... single vitamin D receptor (VDR) ...tween vitamin D levels and myopia; vitamin D deficiency has been shown to influence the development of high myopia ...[20–22]. ...
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Genomic effects of the vitamin D receptor: Potentially the link between vitamin D, immune cells, and multiple sclerosis
... Vitamin D has a plethora of functions that are important for the maintenance of general health and in particular, the functional integrity of the immune system, such as pro- moting an anti-inflammatory ...
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The effect of the epigenome on the Vitamin D Receptor target genes
... is Vitamin D, which interacts with the epigenome ...of Vitamin D3 intake is unique because it is not only obtained by the exposure of sunlight but also via the intake of nutrients ...the ...
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Evidence for in vivo upregulation of the intestinal vitamin D receptor during dietary calcium restriction in the rat
... intracellular vitamin D ...in vitamin D receptor content after exposure to ...enterocyte vitamin D receptor content in vivo, male rats were fed either a normal ...
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Vitamin D Receptor Polymorphisms Are Associated with Reduced Esophageal Vitamin D Receptor Expression and Reduced Esophageal Adenocarcinoma Risk
... that vitamin D exerts a protective effect on the development of various solid ...high vitamin D levels in the development of eso- phageal adenocarcinoma ...the vitamin D ...
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Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug induced osteomalacia
... by vitamin D receptor (VDR), and it is expressed mainly in the kidney, where VDR is also ...xenobiotic receptor (SXR) also enhances the expression of CYP24, providing a new molecular mechanism ...
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Original Article Lower maternal and fetal vitamin D status and higher placental and umbilical vitamin D receptor expression in preeclamptic pregnancies
... fetal vitamin D status in preeclamptic pregnan- ...25(OH) D measurement was ...of vitamin D receptor in placenta and cord tissues of ...fetal vitamin D status in ...
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VITAMIN D RECEPTOR (VDR) GENE POLYMORPHISM AND MATERNAL VITAMIN D DEFICIENCY IN INDIAN WOMEN WITH PRETERM BIRTH (PTB)
... Dietary vitamin D is efficiently absorbed in small intestine and transport to lymphatic system in ...chylomicrons. Vitamin D is a steroid hormone that maintains mineral homeostasis in the ...
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Vitamin D receptor genotype is associated with radiographic osteoarthritis at the knee
... components. Low bone density is a risk factor for osteoporotic fracture while osteoarthritis is associated with increased bone density. The 1,25-dihydroxyvitamin D3 receptor (VDR) gene locus was previously found ...
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A nonclassical vitamin D receptor pathway suppresses renal fibrosis
... (Figure 8A). In contrast, administration of DLAM-iPr and DLAM-4P significantly reduced Serpine1, Acta2, and Col1a1 mRNA levels in UUO kidneys (Figure 8A). Consistent with these results, UUO- induced PAI-1 and α-SMA ...
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The Prognostic Value of Vitamin D Insufficiency & Vitamin D Receptor Gene Polymorphism in Adult Acute Myeloid Leukemia Patients
... After induction therapy, our study demonstrated a statistically significant dif- ference between the VD sufficient and insufficient groups as regard complete remission (CR) rate being 90.5% vs 44.8% respectively. The ...
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Hereditary vitamin D resistant rickets caused by a novel mutation in the vitamin D receptor that results in decreased affinity for hormone and cellular hyporesponsiveness
... (OP) VDRE was examined by GMSA. Following in vitro tran- scription of the normal VDR and H305Q mutant VDR cDNAs, the receptor proteins were produced by in vitro translation us- ing reticulocyte lysates. As shown ...
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