voltage-gated K+ channel
Multiple mechanisms mediating carbon monoxide inhibition of the voltage-gated K+ channel Kv1.5
... The voltage-gated K + channel has key roles in the vasculature and in atrial excitability and contributes to apoptosis in various ...the channel, which had previously been suggested as ...
10
The voltage gated K+ channel subunit Kv1 1 links kidney and brain
... in voltage-gated K + channel subtype ...mutant channel is dysfunctional and speculate that Mg 2+ wasting results from changes in apical membrane voltage along the ...apical ...
5
Functional antagonism of voltage gated K+ channel α subunits in the developing brain ventricular system
... Judging by an increased cell proliferation and extrusion of cells, the integrity of the neuroepithelial layer is compromised very early, at least a day before hydrocephalus. Why does cell extrusion happens in the third ...
12
Hypoxia inhibits gene expression of voltage gated K+ channel alpha subunits in pulmonary artery smooth muscle cells
... KV channel alpha subunits, ...KV channel beta subunits (KVbeta1, KVbeta2, and KVbeta3). The native K+ channels are composed of pore-forming alpha and auxiliary beta ...
8
Molecular and genetic basis of sudden cardiac death
... Congenital LQTS. The QT interval measured by standard surface ECG provides a surrogate measurement of the average ventricu- lar action potential duration. Both a prolonged or shortened QT interval indicates an increased ...
10
The voltage gated Kv1 3 K+ channel in effector memory T cells as new target for MS
... Kv1.3 channel numbers following mitogen activation in T cells from eight MS patients who had not begun immunotherapy and returned for clinical visits during the course of the study, and from six healthy ...
12
pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1
... the channel is perfectly selective [31,32], which suggests that protons permeate proton channels by a hydrogen- bonded chain mechanism [33] that does not require a continuous aqueous ...the voltage-sensing ...
10
Silencing of voltage-gated potassium channel K 9.3 inhibits proliferation in human colon and lung carcinoma cells
... that K V ...showing K V ...silencing K V ...40], K V ...[12], K V 1.3 channels in lung adenocarcinoma cells [13], and K V ...showing K V ...silencing K V ...of ...
12
Selectivity Mechanism of the Voltage-gated Proton Channel, H V
... (6) Lim, C.; Bashford, D.; Karplus, M. J. Phys. Chem. 1991, 95, 5610. (7) Ozutsumi, K.; Ishigiro, S. Bull. Chem. Soc. Jpn 1992, 65, 1173. (8) Smith, R. M.; Martell, A. E. Sci. Total Environ. 1987, 64, 125. (9) ...
20
Molecular basis of ion permeability in a voltage gated sodium channel
... the channel (Appendix Fig S7A), again consistent with the electrophysiology ...the channel, but the small interaction energies with the polypeptide would not enable compensatory desolvation (as occurs in ...
12
Cloning and functional expression of voltage gated ion channel subunits from cnidocytes of the Portuguese Man O'War Physalia physalis
... ion channel subunits, 12 cnidocytes were removed from a suspension of purified cells by aspiration into a fine glass pipette whose tip diameter was slightly larger than that of ...the K + channel, ...
11
Perspective The gp91 phox Component of NADPH Oxidase Is Not a Voltage-gated Proton Channel
... opposing voltage would shut down the oxidase within 20 ...by voltage-gated proton chan- nels. A recent suggestion that K efflux contributes 6% of the total charge compensation (Reeves et ...
7
The voltage gated Ca2+-channel Cav3.2 and therapeutic responses in breast cancer
... Brewer K, Aldrich JS, Yu H, Dawson ES, Li M, McManus O, Jones CK, Daniels JS, Hopkins CR, Xie XS, Conn PJ, Weaver CD, Lindsley ...calcium channel inhibitor with robust effects in STN neurons and in a rodent ...
15
A kinetic study of receptor activation of the G-protein gated K+ channel
... Na^, K^, Ca^^ or Cl' ions are responsible for excitation and electrical signaling in the nervous ...a voltage change across the membrane, a neurotransmitter, a cytoplasmic second messenger, and so on - is ...
347
Aspartate 112 is the selectivity filter of the human voltage-gated proton channel
... The Cl – permeability of D112H was completely unexpected, given strong precedents for His imparting proton selectivity to channels. Histidine shuttles protons in K 1 or Na 1 channel VSDs with ArgRHis ...
6
Identification of Mutation in SCN4A, Hot-Spot for Periodic Paralyses, in a Large Chinese Family with a Typical Normokalemic PP Using the Whole-Exome Sequencing
... a-subunit, voltage-gated sodium channel, ...the voltage sensor and by rotamer conformations of R4 ...potassium channel gene such as KCNE3, in which mutations are a rare cause of ...
5
Voltage-gated proton channel in a dino agellate
... Proton channel genes were subsequently identi fi ed in human, mouse, and Ciona intestinalis, but their existence in dino- fl agellates remained uncon fi ...ton channel gene from a Karlodinium vene fi cum cDNA ...
10
Construction and validation of a homology model of the human voltage-gated proton channel hH 1
... 25 simulations were performed on each of the top five models from each alignment (see Materials and methods). In each of these simulations, the system was allowed to evolve in the octane slab at 300 K for 100 ns ...
23
The Eag potassium channel as a new prognostic marker in ovarian cancer
... control voltage gradients across the plasma membranes of all living cells by allowing the flow of ions down their electrochemical gradient ...[3]. Voltage gated potassium (K + ) channels have ...
8
Molecular cloning of a glibenclamide sensitive, voltage gated potassium channel expressed in rabbit kidney
... total volume of 30 m l. The reaction mixture was overlaid with 50 m l of mineral oil and incubated at 50 8 C for 16 h. The total amount of RNA in each sample was kept constant (100 m g) by adding the appropriate amount ...
10