Wild type and transgenic mice
Genetic Immunization of Wild-Type and Hepatitis C Virus Transgenic Mice Reveals a Hierarchy of Cellular Immune Response and Tolerance Induction against Hepatitis C Virus Structural Proteins
... The mice did not exhibit any long-term patho- logical effects from the expression of the HCV ...both wild-type and transgenic mice and demonstrate an inter- esting hierarchy of immune ...
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Excretion of Wild-Type and Vaccine-Derived Poliovirus in the Feces of Poliovirus Receptor-Transgenic Mice
... of wild-type poliovirus, oral polio vaccine, and cVDPV (Hispaniola) strains after intraperitoneal injection in poliovirus receptor-transgenic ...of wild-type poliovirus type ...
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High Pathogenicity of Wild-Type Measles Virus Infection in CD150 (SLAM) Transgenic Mice
... generated transgenic mice ubiquitously expressing the human protein SLAM (signaling lymphocytic activation molecule), or CD150, recently identified as an MV ...receptor transgenic models described so ...
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Isolation of Novel Synthetic Prion Strains by Amplification in Transgenic Mice Coexpressing Wild-Type and Anchorless Prion Proteins
... or transgenic mice overexpressing glycosylphosphatidylinositol (GPI)-anchored PrP C ...into mice that express wild-type (wt) levels of PrP C and that synthetic prion strain propagation ...
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Spontaneous hepatic repopulation in transgenic mice expressing mutant human α1 antitrypsin by wild type donor hepatocytes
... expressing wild-type AAT might have a competitive advantage relative to AAT-Z–expressing hepatocytes, using transgenic mice expressing human ...AAT-Z. Wild-type donor hepatocytes ...
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Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3
... of transgenic (Tg) mice expressing human wild-type (WT) MATR3 (MATR3 WT ) and ALS-mutant F115C MATR3 (MATR3 F115C ) proteins under the control of the mouse prion promoter ...of mice ...
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Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein
... of wild-type human alpha-synuclein may be too low in Tg(SNCA)1Nbm/J mice to allow for a more severe type of synucleinopathy to ...in wild-type mice [12]. Moreover, M83 +/− ...
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Developmental Expression of Wild-Type and Mutant Presenilin-1 in Hippocampal Neurons from Transgenic Mice: Evidence for Novel Species-Specific Properties of Human Presenilin-1
... The distribution of PS 1 in the transgenic neurons expressing human wtPS I and the M146L mutant was also investigated to determine whether the human proteins localized in a markedly diff[r] ...
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Longitudinal chemokine profile expression in a blood-brain barrier model from Alzheimer transgenic versus wild-type mice
... It should be noted that most data from the literature on the BBB failure and the presence of PBMCs in parenchyma are observed very late on postmortem samples. On the con- trary, recent imaging studies to assess the ...
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Molecular Analysis of the Protease-Resistant Prion Protein in Scrapie and Bovine Spongiform Encephalopathy Transmitted to Ovine Transgenic and Wild-Type Mice
... ovine transgenic mice infected with the BSE agent inoculated either from an experimentally infected sheep or from a second pas- sage in C57BL/6 ...human transgenic mice infected with ...
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Acquired transmissibility of sheep-passaged L-type bovine spongiform encephalopathy prion to wild-type mice
... Salguero FJ, Parra B, Segundo FD, Sanchez-Vizcaino JM, Rogers M, Torres JM (2004) Subclinical bovine spongiform encephalopathy infection in transgenic mice expressing porcine prion protein. J Neurosci ...
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Antiviral immune responses in CTLA4 transgenic mice.
... tg mice, B7-CD28 interactions became limiting for IgG responses in all of the instances tested here, less for ...tg mice (squares) and nontransgenic littermates (triangles) with 2 3 10 6 PFU of LCMV WE, ...
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Transmission of Elk and Deer Prions to Transgenic Mice
... of transgenic (Tg) mice expressing prion protein (PrP) from Rocky Mountain elk (Cervus elaphus nelsoni), denoted Tg(ElkPrP), and two lines of Tg mice expressing PrP common to white-tailed deer ...
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B cell lymphoma in hiv transgenic mice
... a wild type (WT) FVBN mouse were used as a control polyclonal B cells show four bands corresponding to D-JH1, D-JH2, D-JH3 and D-JH4, indicating that these four segments were rearranged, while tumors were ...
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Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice
... Cristian A Lasagna-Reeves, Diana L Castillo-Carranza, Urmi Sengupta, Audra L Clos, George R Jackson and Rakez Kayed * Abstract Background: The correlation between neurofibrillary tangles of tau and disease progression in ...
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Morphometric analysis of the small intestine in wild type mice C57BL/6L - a developmental study
... A combination of morphometric analysis and animal experiments is increasingly providing impor- tant information relevant to cancer and its genetic background. Most animal work has focused on the familial cancer genes ...
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Haplotypes that are mosaic for wild-type and t complex-specific alleles in wild mice.
... The preponderance of mosaic haplotypes in both groups of mice can be explained by any one of the following hypotheses: genetic recombination between t haplotypes and their w[r] ...
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Chikungunya Virus Arthritis in Adult Wild-Type Mice
... adult wild-type mouse model of chikungunya virus arthritis, which recapitulates the self-limiting arthritis, tenosynovitis, and myositis seen in ...protected mice against chikungunya virus disease, ...
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Igf2 Gene Expression Levels in Wild-Type and Mutant Mice
... in wild-type mice during development and is altered in several mutant mice bearing deletions at the Igf2/H19 ...both wild-type and mutant ...all mice analyzed, except in ...
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How to construct transgenic mice
... Generation of gene deficient mice „knock-out“ 4.. Future of knock-out mice??.[r] ...
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