WNT/beta-catenin
Hypothesis of Opposite Interplay Between the Canonical WNT/beta-catenin Pathway and PPAR Gamma in Primary Central Nervous System Lymphomas
... canonical WNT/beta-catenin pathway, TNF-alpha, interleukin (IL)-1, IL-13, Connective Tissue Growth Factor (CTGF), leptin, and lysophosphatidic acid (LPA) (Simon et ...canonical WNT target and ...
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<p>Nr5a2 promotes tumor growth and metastasis of gastric cancer AGS cells by Wnt/beta-catenin signaling</p>
... the Wnt/beta- catenin signaling pathway in human GC ...of Wnt/beta-catenin ...and beta-catenin signaling pathways, were decreased as ...the ...
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Studies of the Wnt/Beta-catenin signalling pathway in chronic myeloid leukaemia
... Beta-catenin is a non-enzymatic 781 amino acid protein encoded by the CTNNB1 gene which plays a crucial role in both cell adhesion and Wnt signalling. There are various parts of the β-catenin ...
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MiR 92b inhibitor promoted glioma cell apoptosis via targeting DKK3 and blocking the Wnt/beta catenin signaling pathway
... the Wnt/beta-catenin signaling path- way, such as Bcl2, c-myc, c-Jun and ...of beta-catenin (Figure 4A), which suggested that miR-92b modulated beta-catenin via ...the ...
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Role of Wnt/β-catenin signaling in hepatocellular carcinoma, pathogenesis, and clinical significance
... with Wnt/β-catenin signalling and represents the transporter of gadoxetic acid in hepatocellular carcinoma, 80–1087, Copyright (2014), with permission from ...
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Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma
... whether Wnt/ b -catenin signaling could directly induce miR-181 expression, we first used HuH7 cells with stable WNT10B expression (HuH7 WNT10B R8) ...the Wnt/b-catenin pathway through ...
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Wnt/beta catenin signaling in embryonic stem cell converted tumor cells
... of Wnt/β-catenin signaling might include up-regulation of target gene, disruption of linked signal- ing, deregulation of cell proliferation and disruption of cell adhesion ...activated ...
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<p>New Advances in Canonical Wnt/β-Catenin Signaling in Cancer</p>
... Porcupine is a membrane-bound O-acyltransferase, which has been the focus of attention as a key enzyme for Wnt ligand synthesis. Small molecule inhibitors that specifically target Porcupine, such as LGK974 and C59 ...
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Overexpression of CD300A inhibits progression of NSCLC through downregulating Wnt/β-catenin pathway
... in Wnt/ β -catenin pathway were detected by Western ...the Wnt/ β -catenin pathway in A549 and H1650 ...the Wnt/ β -catenin pathway was involved in the suppression effect of ...
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Wnt/beta-catenin pathway: modulating anticancer immune response
... β- catenin was activated during development of mixed- lineage leukemia (MLL) ...on Wnt/β-catenin pathway in addition to other important pathways like PI3K/Akt/mTOR and JAK/STAT for ac- quiring ...
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ABERRANT EXPRESSION OF WNT/BETA CATENIN SIGNALING PATHWAY AND IN VITRO CYTOTOXIC ACTIVITY OF TRADESCANTIA SPATHACEA MEDICINAL PLANT USED TO TREAT HUMAN BREAST ADENOCARCINOMA (MCF 7 CELL LINES)
... A Wnt gene (Wnt1) was first discovered in mouse mammary tumor 12, 13 . Wnt signaling, β-catenin plays crucial impact in stem cells development and ...via Wnt/β-catenin signaling pathway ...
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Formation of synovial joints and articular cartilage
... in Wnt/beta-catenin signalling joints did form, but displayed a defective flat cell layer normally abutting the synovial cavity and expressed markedly reduced levels of ...
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Circular RNAs: Regulators of Cancer-Related Signaling Pathways and Potential Diagnostic Biomarkers for Human Cancers
... CircRNAs are relatively stable in animal cells and can regulate the target gene expression in several ways. First, circRNAs, have a covalently closed loop with no 5'-3' polarity or poly A tail; the circular loop consists ...
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EpCAM- AN OLD CANCER ANTIGEN, TURNED ONCOGENIC RECEPTOR AND ITS TAGETING IMMUNOTHERAPY
... . Wnt binds to receptors of the Frizzled family on the ...to beta-catenin, which accumulates initially in the cytoplasm, and then enters the nucleus where it binds a lymphoid enhancer factor/T-cell ...
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Novel mutation G324C in WNT1 mapped in a large Pakistani family with severe recessively inherited Osteogenesis Imperfecta
... Osteogenesis imperfecta (OI) is a genetic disorder with se- vere bone abnormalities and is the most common form of primary osteoporosis in children [1]. Clinical phenotype may vary from prenatal lethal forms to milder ...
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A review on the diagnosis and treatment of hepatocellular carcinoma with a focus on the role of Wnts and the dickkopf family of Wnt inhibitors
... the Wnt pathway has been identified as contributing to the development and progression of ...the Wnt pathway is the dickkopf (DKK) family of Wnt ...DKK, beta-catenin, morphogen, ...
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Inactivation of the Wnt/β-catenin signaling pathway underlies inhibitory role of microRNA-129-5p in epithelial–mesenchymal transition and angiogenesis of prostate cancer by targeting ZIC2
... canonical Wnt signaling pathway, extensively conserved in the animal kingdom, is essential for embry- onic development and adult tissue homeostasis ...the Wnt/β-catenin signaling pathway ...
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Original Article Highly expressed DDX10 promotes hepatocellular carcinoma cell proliferation through Wnt/β-catenin signaling
... and Wnt/β-catenin signaling. We then find that the activity of Wnt/β-catenin signaling is positively correlated with the level change of ...
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Original Article TRAF4 enhances oral squamous cell carcinoma cell growth, invasion and migration by Wnt-β-catenin signaling pathway
... understood Wnt signaling pathway and is highly conserved during ...that Wnt/β-catenin pathway possesses multiple roles in regulating diverse physiological processes, including cell prolifer- ation, ...
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PDIA6 promotes the proliferation of HeLa cells through activating the Wnt/β-catenin signaling pathway
... MG-132. Western blotting demonstrated that MG-132 restored β-catenin levels in HeLa cells transfected with pCMV-sport6 similar to that transfected with pCMV- sport6-PDIA6 (Figure 5A and 5B). As β-catenin is ...
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