Wnt/PCP
Wnt/PCP signaling controls intracellular position of MTOCs during gastrulation convergence and extension movements
... The second type of polarity, a developing planar cell polarity, was exhibited by biased MTOC positions relative to the body axes in cells undergoing C&E movements. The centrosome organizes the MT cytoskeleton during ...
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The non canonical Wnt PCP pathway shapes the mouse caudal neural plate
... The last stage of neural tube (NT) formation involves closure of the caudal neural plate (NP), an embryonic structure formed by neuromesodermal progenitors and newly differentiated cells that becomes incorporated into ...
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Genetic analysis of Wnt/PCP genes in neural tube defects
... 30 Wnt/PCP pathway genes based on KEGG data- bases [23], and the variants were detected using targeted capture and next generation DNA sequencing ...of Wnt/PCP pathway genes in human NTD cases ...
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Wnt activity guides facial branchiomotor neuron migration, and involves the PCP pathway and JNK and ROCK kinases
... of PCP, including convergent extension movements (for example, [7,8]), and cochlear hair cell orientation ...other Wnt/PCP components that play a functional role in FBM migration are widely expressed ...
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Ptk7 promotes non canonical Wnt/PCP mediated morphogenesis and inhibits Wnt/β catenin dependent cell fate decisions during vertebrate development
... in Wnt signal transduction during embryonic development and in ...canonical Wnt/β-catenin ...canonical Wnt/β-catenin activity in vivo ...canonical Wnt-dependent fate specification within ...
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PRDM15 loss of function links NOTCH and WNT/PCP signaling to patterning defects in holoprosencephaly
... Genes encoding transcription factors (TFs) and epigenetic regu- lators are relevant etiological candidates given their central role in integrating signaling cascades and orchestrating multiple biological processes. ...
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A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway
... and WNT/PCP signaling, we per- formed co-IP and immunoblotting experiments in HEK293T cells after overexpression of LRRK2 and some WNT/PCP signaling components, such as Ror2, Vangl2, Prickle1, ...
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Original Article CTHRC1 promotes human colorectal cancer cell proliferation and invasiveness by activating Wnt/PCP signaling
... Abstract: Collagen triple helix repeats containing 1 (CTHRC1) participates in vascular remodeling, bone formation, and developmental morphogenesis. Recently, CTHRC1 has been found up-regulated in many solid tumors and ...
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Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling
... the Wnt/PCP signaling pathway. PCP in vertebrates is regulated by non-canonical Wnt signaling, and a set of core PCP pathway components, which includes Vangl2, frizzled 3/6 and ...
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A phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling
... and Wnt signaling ...non-canonical Wnt signaling is inhibited during the tail protrusion process, we suspected a constituent of this extract to act as a modulator of these ...non-canonical Wnt ...
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Wnt/PCP proteins regulate stereotyped axon branch extension in Drosophila
... the Wnt/PCP pathway act to localize Fz asymmetrically within cells (Strutt, 2001; Strutt, 2003; Klein and Mlodzik, 2005; Strutt and Strutt, 2009; Vladar et ...
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Distinct Xenopus Nodal ligands sequentially induce mesendoderm and control gastrulation movements in parallel to the Wnt/PCP pathway
... non-canonical Wnt pathway, which exhibits analogies with the fly planar cell polarity (PCP) pathway (Solnica-Krezel, 2005; Wallingford et ...non-canonical Wnt pathway is triggered by Wnt11, which ...
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Mechanical control of tissue and organ development
... of PCP in the forming wing by acting in concert with denticle field-specific effectors (Walters et ...regulates Wnt/PCP signaling, which controls junctional resistance sites (Figs 2, 3) crucial to ...
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Gpr125 modulates Dishevelled distribution and planar cell polarity signaling
... and PCP components and planar polarity defects of Gpr125 overexpressing gastrulae are consistent with a role of Gpr125 in modulating Wnt/PCP ...vertebrate Wnt/PCP signaling (Park et ...
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Swap70b is required for convergent and extension cell movement during zebrafish gastrulation linking Wnt11 signalling and RhoA effector function
... non-canonical Wnt/PCP pathway (Hammerschmidt et ...non-canonical Wnt/PCP pathway, Wnt11 is predominantly required anteriorly while Wnt5b is essential in the posterior parts of the embryo (Tada ...
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Defective neuroepithelial cell cohesion affects tangential branchiomotor neuron migration in the zebrafish neural tube
... The observation that in Wnt/PCP mutant embryos, FBMNs at the basal side of the neuroepithelium exhibit ectopic movements towards the apical midline of the neural tube instead of initiati[r] ...
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Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation
... in PCP, such as Frizzled (Fz) and Dishevelled (Dsh), but there is also some evidence that it may act as a cell adhesion molecule in a PCP-pathway- independent ...in PCP signalling during ...during ...
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Atmin mediates kidney morphogenesis by modulating Wnt signaling
... Taken together, our results showed that the phenotype observed in the Atmin Gpg6/Gpg6 kidneys most closely resembled that of other PCP pathway mutants. Furthermore, our data suggested that Atmin and Vangl2 might ...
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Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes
... mice, PCP gene mutations produce defects in neural tube and eyelid closure, elongation of the cochlea and orientation of hair follicles in the skin and of sensory hair bundles in the inner ear (Wang and Nathans, ...
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The polarity protein VANG 1 antagonizes Wnt signaling by facilitating Frizzled endocytosis
... the PCP gene Van Gogh/ Strabismus/Vangl2, suppressed PVM migration defects of the mig-1 mutant, but it did not affect PVM migration in the otherwise wild- type background ...for Wnt, Dishevelled and β ...
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