Wnt Signaling
<p>Activated Wnt signaling promotes growth and progression of AFP-producing gastric cancer in preclinical models</p>
... canonical Wnt signaling (marked by inactive destruction complex including GSK3β dephosphorylation/inactivation, and reduced Axin 1, increased active β-catenin, augmented TCF transcriptional activity and ...
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Wnt signaling in regulation of biological functions of the nurse cell harboring Trichinella spp
... of Wnt ligands responsible for activation of canonical Wnt signaling cascade, the latter known to accompany induction of muscle regeneration [8, 22], may reflect the vestiges from those stages of NC ...
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Role of canonical Wnt signaling/β catenin via Dermo1 in cranial dermal cell development
... for Wnt/-catenin signaling in early cranial dermal development (Brault et ...canonical Wnt signaling activity reporter and the Wnt responsive Axin2 mRNA are transiently expressed, ...
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Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis
... canonical WNT inhibitor Dkk1 display a complete block in the formation of all five pairs of mammary placodes, based on the results of scanning electron microscopy and whole-mount in-situ hybridization with several ...
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Aberrant Wnt Signaling in Leukemia.
... the Wnt proteins: Wnt5b, Wnt6, Wnt10a, Wnt14, and Wnt16 as compared to normal B cells ...canonical Wnt signaling is crucial for CLL ...the Wnt-pathway in CLL by studying the methylation status ...
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The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective
... the Wnt signaling pathway is that β-cat/TCF mediates not only the effect of Wnt ligands, but also other cell signaling molecules during adulthood, including insulin, IGF-1, as well as peptide ...
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Wnt signaling and its downstream target N myc regulate basal progenitors in the developing neocortex
... The Wnt–-catenin pathway promotes both proliferation and neuronal differentiation of neocortical ...NPCs. Wnt signaling induces the expression of Ngn1/2, and thus promotes neocortical neuronal ...
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Reiterated Wnt signaling during zebrafish neural crest development
... that Wnt/β- catenin signaling is also involved later in neural crest cell fate specification after crest cells have been ...of Wnt/β-catenin signaling in pre-migratory zebrafish neural crest ...
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Cilia, Wnt signaling, and the cytoskeleton
... many signaling pathways and as a microtubule organizing ...into signaling and cell function. Of the many signaling pathways associated with primary cilia, the most extensively studied in association ...
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Wnt signaling in development and disease
... canonical Wnt signal- ing in skeletal development, we utilized a canonical Wnt signaling reporter mouse strain Top-Gal in which lacZ ex- pression reflects active canonical Wnt ...canonical ...
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Original Article Oxidized phospholipids inhibit canonical Wnt signaling and osteoblast differentiation via ERK activation
... BMP-2 signaling via activation of the ERK pathway ...Hedgehog signaling and osteogenic differentiation of BM-MSCs by inducing oxidative stress ...attenuating Wnt signaling and ...
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Wnt signaling: a promising target for osteoarthritis therapy
... critical signaling pathways as key regulators and activators of cellular and molecular processes during OA ...development. Wnt signaling is one such pathway whose signaling molecules and ...
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Parathyroid hormone related protein activates Wnt signaling to specify the embryonic mammary mesenchyme
... Canonical Wnt signaling involves a triad of intracellular proteins (adenomatous polyposis coli, axin 1 and glycogen synthase kinase-3 ) that phosphorylate cytoplasmic -catenin and target it for ...
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The Effects of Tracheal Occlusion on Wnt Signaling in a Rabbit Model of Congenital Diaphragmatic Hernia
... of Wnt expression was that Wnt2 was highly expressed during early lung development in normal control fetuses, decreased over time, and was low at term on E21 ...of Wnt signaling pathway genes during ...
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Glucocorticoid dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice
... process, Wnt/ β -catenin signaling is required to suppress chondrogenesis and to allow osteoblasts to form (Day et ...canonical Wnt pathway that promotes degradation of β -catenin, display premature ...
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Wnt Signaling in Sexual Dimorphism
... Dpp signaling, is required to maintain GSC ...Upd-JAK-STAT signaling pathway is compromised, the GCSs fail to self-renew and instead undergo ...STAT signaling is inappropriately upregulated, GSCs ...
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The Wnt signaling regulator R spondin 3 promotes angioblast and vascular development
... factor signaling pathways, such as VEGF, TGF β , BMP4 and hedgehog, have been identified that are required directly or indirectly for formation of both lineages (Dickson et ...-catenin signaling plays a key ...
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Mesenchymal Wnt/β catenin signaling limits tooth number
... Mesenchymal Wnt/ β -catenin signaling is downregulated during continuous tooth formation in β -cat Δex3K14/+ mutants We have previously shown that stabilization of β -catenin in the oral epithelium of mouse ...
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6. R.Prakash and S.Anandakumar
... of Wnt/canonical pathway was identified in the development of begin and malignant breast ...of Wnt ligands and decreased activity of Wnt/Ca 2+ pathway (Howe and Brown, 2004; Clevers and Nusse, ...
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Identification of COX5B as a novel biomarker in high-grade glioma patients
... Methods: In this study, we devised a bioinformatics strategy to map patterns of oncogenic pathway activation in glioma, from the Gene Expression Omnibus (GEO). Bioinformatics analysis revealed that 749 genes were ...
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