Wnt/β-catenin pathway
Docking studies reveal zerumbone targets β-catenin of the Wnt–β-catenin pathway in breast cancer
... The Wnt–β-catenin pathway appears to be deregulated in most can- cer cells including breast ...the Wnt–β-catenin pathway is relat- ively unknown, especially ...
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Original Article MicroRNA-29 mediates TGFβ1-induced extracellular matrix synthesis by targeting wnt/β-catenin pathway in human orbital fibroblasts
... of β-catenin whether the treatment of TGFβ1 was used or ...of wnt/β-catenin ...of Wnt/β-catenin pathway in hu- man ...
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Promoter methylation analysis of WNT/β-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer
... extracellular WNT inhibitors [WNT inhibitory factor-1 (WIF1), DKK3, SFRP2, SFRP4, SFRP5], cytosolic WNT antagonists (AXIN2, APC), nuclear proteins [sex deter- mining region Y related box 7 (SOX7) and ...
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LncRNA CASC11 promotes the cervical cancer progression by activating Wnt/beta-catenin signaling pathway
... ing Wnt/β-catenin pathway [9], but also facilitated the cell proliferation, migration and invasion in hepato- cellular carcinoma and in gastric cancer via activating PI3K/AKT signaling ...
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Regulation of Wnt/β-catenin signaling by posttranslational modifications
... Gsk3 β have redundant function in the Wnt/ β -catenin pathway ...canonical Wnt signaling regulates Gsk3 to inhibit β -catenin proteolysis remains largely ...in ...
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Circular RNAs Regulate Cancer Onset and Progression via Wnt/β Catenin Signaling Pathway
... the Wnt/β-catenin pathway, which controls a plethora of cellular pro- cesses that drive cancer ...and Wnt/β-catenin signaling pathway presents potential diagnostic ...
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PubMedCentral-PMC5647938.pdf
... canonical Wnt signal- ing as a pathway disrupted in ...involving β -catenin, Brn2, and Tbr2, causing an expansion of the IP cell population and ASD-related aberrant social behavior (Belinson ...
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Grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis
... of β- catenin results in accelerated tumor cell proliferation and tumor progression through the transcriptional acti- vation of target genes including c-Myc, cyclin D1 and COX-2 ...nuclear β- ...
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LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma
... signalling pathway that is frequently disrupted during tumorigenesis is the canonical Wnt/β- catenin ...secreted Wnt ligands to Frizzled and LRP5/6 receptors, which triggers ...
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PITX2 enhances progression of lung adenocarcinoma by transcriptionally regulating WNT3A and activating Wnt/β-catenin signaling pathway
... the Wnt/β-catenin pathway ...and Wnt/ β-catenin pathway, which provides a new sight into the pathogenesis of ...
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Loss of β-catenin in adrenocortical cancer cells causes growth inhibition and reversal of epithelial-to-mesenchymal transition
... The Wnt signaling pathway has crucial roles in the regulation of cellular, embryological and physiological activities ...mutated pathway components, underscoring the importance of the Wnt ...
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Deubiquitinase USP9X deubiquitinates β-catenin and promotes high grade glioma cell growth
... the Wnt/β-catenin signal pathway through ...the Wnt/β- catenin ...a Wnt ligand, we found that USP9X knockdown partly blocked the activation of Wnt/β- ...
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Original Article PFTK1 promotes the progression of non-small cell lung cancer (NSCLC) through the Wnt/β-catenin signaling pathway
... Abstract: PFTK1, as a Cdc-related serine/threonine protein kinase, is a crucial regulator of cyclins and cell cycle. However, the role of PFTK1 in non-small cell lung cancer (NSCLC) remains elusive. In the present study, ...
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Deregulation of secreted frizzled-related proteins is associated with aberrant β-catenin activation in the carcinogenesis of oral submucous fibrosis
... identified Wnt antagonists, have been well recognized as tumor suppressors in multiple human cancers through suppressing the Wnt/β-catenin ...and β-catenin in normal oral ...
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Roles of transcriptional factor 7 in production of inflammatory factors for lung diseases
... CD3E, β -catenin, TCF7L2, LEF-1, IL-17, IL-4, or Eomes) and is involved in several signal pathways ...(e.g. Wnt, FoxO1, Notch, or P21pathways) which are criti- cal for lung diseases, especially the ...
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Molecular markers associated with outcome and metastasis in human pancreatic cancer
... Finally we identified a PDAC metastasis-related genetic profile containing 358 differentially expressed genes be- tween the primary tumour and metastatic tissue. Molecu- lar knowledge on the metastatic process in PDAC is ...
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<p>BCL11A enhances stemness and promotes progression by activating Wnt/β-catenin signaling in breast cancer</p>
... the Wnt/ β -catenin pathway is crucial for the acquisition of uncontrolled cell proliferation and ...the Wnt inhibitor Dkk1 led to a different result, which indicated a weaker ...
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EFEMP2 suppresses epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway in human bladder cancer
... the Wnt/β-catenin signaling in T24 ...and Wnt/β-catenin factors (β-catenin, c-Myc, cyclin D1) reasoned by EFEMP2 interfering or upregulation can be recovered by ...
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Original Article TRAF4 enhances oral squamous cell carcinoma cell growth, invasion and migration by Wnt-β-catenin signaling pathway
... Wnt/β-catenin pathway ranks as the best understood Wnt signaling pathway and is highly conserved during ...that Wnt/β-catenin pathway possesses ...
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TRIM29 facilitates the epithelial-to-mesenchymal transition and the progression of colorectal cancer via the activation of the Wnt/β-catenin signaling pathway
... stabilizing β-catenin and altering β-catenin subcellular localization, and the progression of cervical cancer by increasing β-catenin expression [22, ...B pathway but ...
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