X-box binding protein (XBP1)
X Box Binding Protein XBP-1s Transactivates the Kaposi's Sarcoma-Associated Herpesvirus (KSHV) ORF50 Promoter, Linking Plasma Cell Differentiation to KSHV Reactivation from Latency
... Reactivation of lytic replication from viral latency is a defining property of all herpesviruses. Despite this, the authentic physiological cues for the latent-lytic switch are unclear. Such cues should ensure that viral ...
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Induction of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interleukin-6 by X-Box Binding Protein 1
... (active) X-box binding protein-1 (XBP-1s), a transcription factor activated by endoplasmic reticulum (ER) stress and differentiation of B cells in lymph ...
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The transcription factor X-box binding protein-1 in neurodegenerative diseases
... Unfolded Protein Response ...defective, protein aggregates overwhelm cells and affect, among other mechanisms, synaptic function, signaling transduction and cell ...exacerbated protein aggregation, ...
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X-Box Binding Protein 1 Contributes to Induction of the Kaposi's Sarcoma-Associated Herpesvirus Lytic Cycle under Hypoxic Conditions
... Kaposi’s sarcoma-associated herpesvirus (KSHV), like other herpesviruses, has two stages to its life cycle: latency and lytic replication. KSHV is required for development of Kaposi’s sarcoma, a tumor of endothelial ...
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X-Box-Binding Protein 1 Activates Lytic Epstein-Barr Virus Gene Expression in Combination with Protein Kinase D
... human protein X-box-binding protein 1 (XBP-1) is a basic-region leucine zipper transcrip- tional activator protein belonging to the cyclic AMP response element-binding ...
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Flavivirus Infection Activates the XBP1 Pathway of the Unfolded Protein Response To Cope with Endoplasmic Reticulum Stress
... transmembrane protein with both serine/threonine kinase and RNase activities (61, ...the protein is then activated by ...the X box binding protein 1 gene (XBP1) is the ...
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IRE1α/XBP1 mediated branch of the unfolded protein response regulates osteoclastogenesis
... and protein synthesis overload, lead to an accumulation of unfolded proteins in the ER lumen, a condition referred to as ER ...unfolded protein response ...inositol-requiring protein-1α (IRE1α). ...
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IRE1α XBP1 pathway promotes melanoma progression by regulating IL 6/STAT3 signaling
... RNA-activated protein kinase-like ER kinase (PERK), which act as proximal sensors of ER ...lated protein 78 ...encoding X-box-binding protein 1 (XBP1) by removing a 26 nt ...
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Endoplasmic reticulum stress cooperates with Toll like receptor ligation in driving activation of rheumatoid arthritis fibroblast like synoviocytes
... unfolded protein response (UPR), aimed at relieving the burden by slowing down the global translation rate while increasing production of a selected set of proteins, par- ticularly ER chaperones ...unfolded ...
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Endoplasmic Reticulum Stress Implicated in the Development of Renal Fibrosis
... promoting protein folding, maturation and secretion to induce ER-associated deg- radation and CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP) expression ...splicing ...
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Thrombin activates a Y box–binding protein (DNA binding protein B) in endothelial cells
... cells) were prepared as already described here. The extract was heat treated (60°C for 2 hours), centrifuged at 21,000 g in a Micromax centrifuge (International Equipment Co., Needham Heights, Massachusetts, USA) for 15 ...
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Hepatitis B Virus X Protein Function Requires Zinc Binding
... Biophysical analyses of recombinant HBx indicate that C61, C69, C115, and C137 are involved in zinc binding. We next performed mass spectrometry-based hydrogen-deuterium exchange (HDX) analysis of the coexpressed ...
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Interaction of SecA with Unfolded Polypeptides
... direct binding assay revealed that although the isolated PPXD fragment, which contained both bulb and stem regions, retained some binding towards the polypeptides, its binding was several times lower ...
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Shrimp miR-965 induced the human melanoma stem-like cell apoptosis and inhibited their stemness by disrupting the MCL-1-ER stress-XBP1 feedback loop in a cross-species manner
... anti-apoptotic protein, which belongs to BCL-2 protein family and is primarily located in the mitochondria, in which it inserts into the mitochondrial membrane via a hydrophobic tail and is implicated in ...
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Validation of reference genes for expression analysis by quantitative real time PCR in Leptinotarsa decemlineata (Say)
... TATA box binding protein, TBP1 and TBP2; ribosomal protein RP4 and RP18; translation elongation factor 1α EF1α) from the transcriptome and validated the stability of their ...
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Some studies in purine metabolism and control
... Cyclic-AMP binding curves for the DEAEcellulose toiumn npeaks A and B Effect of cyclic-GMP on the binding of cyclic-AMP by the binding protein in the 5,000 x g supernatant and two ammoni[r] ...
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High mobility group box 1 protein, lipopolysaccharide binding protein, interleukin 6 and C reactive protein in children with community acquired infections and bacteraemia: a prospective study
... HMGB1 has been known from many years as chromo- somal protein, but in recent years it has been very intensively investigated as a proinflammatory cytokine [9,23]. In 1999, Wang et al [24] found increased levels of ...
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The F box protein family
... a protein motif of approximately 50 amino acids that functions as a site of protein-protein ...F-box protein), in which they bind substrates for ubiquitin-mediated ...F-box ...
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Z(x) and S(x) are the output of S-Box of AES and
... Abstract—This paper presents an efficient hardware implementation of Advance Encryption Standard (AES) and SM4 algorithms on Xilinx Virtex 7 FPGA by exploiting the feature of dynamic partial reconfiguration (DPR) to ...
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Concentrations of TATA box binding protein (TBP) type genes affect chordamesodermal gene expression
... Fig. 2. Optimal concentrations of TBP and TBP2 induced chordamesodermal gene expression at gastrula stage. (A) Effects on gene expression by the various concentrations of TBP at stage 10. Injection of TBP-MO (0.1 ng-10 ...
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