X-chromosome
Nonrandom X chromosome DNA methylation patterns in hemophiliac females
... Molecular X chromosome inactivation analysis was used to characterize three females (and their families) with severe ...paternal X chromosomes were distinguished by restriction fragment length ...
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Sex and gamete specific patterns of X chromosome segregation in a trioecious nematode
... To genotype the X chromosome and autosomal linkage group 4 (LG4), we used 5 polymorphic markers (SNPs) for each chromosome (Data S1). We generated these markers from a draft genome sequence for A. ...
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Gender and gamete specific patterns of X chromosome segregation in a three gendered nematode
... the X chromosomes segregate to the pole fated to become functional ...the X chromosome is inherited through the sperm-producing germline and from father to son in the event of a ...complete X ...
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A new model for random X chromosome inactivation
... X chromosome inactivation (XCI) is a process by which mammals reduce the number of active X chromosomes to one per diploid set of autosomes, thereby allowing for dosage equality between the ...two ...
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A skewed view of X chromosome inactivation
... parental X active. While in most females the number of cells with either X being active is roughly equal, skewing of X chromosome inactivation is observed in a percentage of ...of X ...
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BRCA1 mediated repression of select X chromosome genes
... the X chro- mosome was ...X chromosome. Our investigation shows that genes endogenous to the X chromosome are also repressed by BRCA1 and that genes on certain loci are preferentially ...
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The Evolution of Genomic Imprinting and X Chromosome Inactivation in Mammals
... alternating X and Y chromosomes ...and X chromosome dosage compensation in female eutherian ...between X chromosome inactivation (XCI) and autosomal genomic imprinting that have long ...
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Carrier detection in X linked severe combined immunodeficiency based on patterns of X chromosome inactivation
... whose X chromosome bearing the XSCID mutation was inactivated early in ...inactive X chromosomes and restriction fragment length polymorphisms to distinguish them, we have determined the lymphocyte ...
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Dosage compensation on the active X chromosome minimizes transcriptional noise of X linked genes in mammals
... monosomy, X chromosome gene products would face both the potential problems of dosage deficiency and high gene expression ...expressed X chromosomal genes and diploid autosomal ...from ...
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Activity map of the tammar X chromosome shows that marsupial X inactivation is incomplete and escape is stochastic
... We performed RNA-FISH using two BACs that were labeled with different fluorochromes (Figure 9). These were co-hybridized to male and female fibroblasts. For each comparison, we scored 100 female nuclei in which at least ...
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Revisiting the X Chromosome Inactivation and Its Impact on Female Longevity
... that X-linked loci participate in the selection process, as demonstrated by Chris- tensen et ...inactivated chromosome seem to randomly escape si- lencing, favoring compensation mechanisms ...increases ...
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Mechanics and dynamics of X chromosome pairing at X inactivation
... for X chromosome colocaliza- tion at XCI in the Tsix/Xite ...that X colocalization can be spontaneously attained only when the concentration, or affinity, of molecules is above a critical ...
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Chromosome silencing mechanisms in X chromosome inactivation: unknown unknowns
... the X chromosome or whether it reflects a general asymmetry of repeat transcription from paternal and maternal genomes in early preimplantation ...of X-linked genes in early preimplantation embryos ...
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Mammalian X chromosome inactivation evolved as a dosage compensation mechanism for dosage sensitive genes on the X chromosome
... the X/A expression ratio increased from ...the X chromosome was probably up-regulated as a ...the X/A expression ratio reaches 1, only a small fraction of X genes (159; ...of X ...
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X chromosome inactivation in the cycle of life
... equalize X-encoded gene expression, female somatic cells transcriptionally silence one of the two X chromosomes in a process named X chromosome inactivation (XCI), which leads to mono-allelic ...
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Failure of extra embryonic progenitor maintenance in the absence of dosage compensation
... of X-linked gene expression, termed dosage compensation, is required for the normal development of mammalian ...of X chromosome inactivation (XCI), somatic cells of mammalian females inactivate one ...
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Sexual dimorphism in autoimmunity
... Because X chromosome inactivation (XCI) occurs in early embryonic development, one of two X chromosomes in each cell is ...the X chromosome of maternal or paternal origin ...non-random ...
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Rapid evolution of cancer/testis genes on the X chromosome
... the X chromosome, are mostly members of gene families organized into complex direct and inverted repeats, and are expressed primarily during the spermato- gonial stage of spermatogenesis ...human X ...
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The role of X chromosome inactivation in female predisposition to autoimmunity
... studying X-inactivation patterns. One might examine X-inactivation skewing specifically in thymic dendritic populations, but if the effect is at the level of microenvironment and varies over time, then it ...
8
Drosophila dosage compensation: a complex voyage to the X chromosome
... the X chromosome from autosomes, but also in the spreading of the MSL complex along this ...the X chromosome, with a bias for the bodies of active genes ...the X chromosome that ...
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