X-chromosome inactivation
No evidence that skewing of X chromosome inactivation patterns is transmitted to offspring in humans
... Skewing of X chromosome inactivation (XCI) can occur in normal females and increases in tissues with age. The mechanisms underlying skewing in normal females, however, remain controversial. To better ...
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The Evolution of Genomic Imprinting and X Chromosome Inactivation in Mammals
... the X and the ...for X inactivation in placental ...imprinted X-inactivation and plat- ypus sex chromosome dosage compensation occur via a mechanism that is independent of the ...
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Self assembly and DNA binding of the blocking factor in X chromosome inactivation
... two X chromosomes to equalize X products with respect to ...of X chromosome inactivation ...one X per cell which is protected from inactivation, as the second X is ...
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Analysis of skewed X chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases
... Genomic DNA was extracted from 10 ml of peripheral blood lymphocyte of patients and controls using standard methods [16]. Genotyping of a polymorphic site in the androgen recep- tor (AR) gene was performed and quantified ...
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The role of X chromosome inactivation in female predisposition to autoimmunity
... in X inactivation patterns between buccal mucosa (an ectodermally derived tissue) and peripheral blood (mesoderm) in the same indi- vidual (unpublished ...certain X-linked alleles during embryonic ...
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Escape of X linked miRNA genes from meiotic sex chromosome inactivation
... numerous X-linked mRNA genes have been shown to escape X chromosome inactivation in female somatic cells, no X-linked mRNA gene has yet been shown unequivocally to escape MSCI in ...
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Mammalian X chromosome inactivation evolved as a dosage compensation mechanism for dosage sensitive genes on the X chromosome
... supernumerary X chromo- somes increases, for example in XXXY and XXXXY males ...any X aneuploidy syn- ...other X aneuploidy syndromes, which would make sense as these syndromes often relate to the ...
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Sexual dimorphism in autoimmunity
... Because X chromosome inactivation (XCI) occurs in early embryonic development, one of two X chromosomes in each cell is ...the X chromosome of maternal or paternal origin ...
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Meiotic sex chromosome inactivation
... somatic X chromosome inactivation (XCI) (see Table ...an X-encoded RNA called Xist (inactive X specific transcript), which coats the X chromosome from which it is ...
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X chromosome inactivation in the cycle of life
... equalize X-encoded gene expression, female somatic cells transcriptionally silence one of the two X chromosomes in a process named X chromosome inactivation (XCI), which leads to ...
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Revisiting the X Chromosome Inactivation and Its Impact on Female Longevity
... that X-chromosome inactivation is a random process in approximately 90% of normal women and gives rise to two mosaic cell populations, the interactions between both cell types determine the “quality” ...
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A skewed view of X chromosome inactivation
... parental X active. While in most females the number of cells with either X being active is roughly equal, skewing of X chromosome inactivation is observed in a percentage of ...of ...
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De novo DNA methylation is dispensable for the initiation and propagation of X chromosome inactivation
... and X chromosome inactivation ...the X-linked genes between males and females is functionally equalized by inactivating one of the two X chromosomes in female somatic cells during early ...
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A new model for random X chromosome inactivation
... X chromosome inactivation (XCI) is a process by which mammals reduce the number of active X chromosomes to one per diploid set of autosomes, thereby allowing for dosage equality between the ...
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Dynamics of gene silencing during X inactivation using allele specific RNA seq
... on chromosome X are largely stable between female ES_Tsix ‐ stop and male J1 ESCs ...of chromosome X [29] colocalize with topologically associated domains (TADs) ...
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The Trithorax group protein Ash2l and Saf A are recruited to the inactive X chromosome at the onset of stable X inactivation
... addition of doxycycline. Focal Ash2l staining was observed in 90% of these cells (Fig. 1A). When Xist deletion was induced by the addition of doxycycline, Ash2l foci were lost within 3 days (Fig. 1A). We also observed ...
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Characterization of X Linked SNP genotypic variation in globally distributed human populations
... for X-linked and auto- somal markers are nearly the same; for the Middle Eastern populations, the confidence intervals of the two values overlap (it should be noted, however, that the X chromo- some value ...
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Disruption of a conserved region of Xist exon 1 impairs Xist RNA localisation and X linked gene silencing during random and imprinted X chromosome inactivation
... X inactivation is the dosage compensation mechanism that has evolved in mammals to ensure equal levels of X-linked gene products in females (XX) and males ...(inactive X specific transcripts) ...
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Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X linked combined immunodeficiency
... chromosome inactivation in PMNs was variable. Findings from this analysis prompted sequencing of the gamma c gene in this pedigree. A missense mutation in the region coding for the cytoplasmic portion of ...
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Clonal analysis of palmar fibromatosis: a study whether palmar fibromatosis is a real tumor
... of X-chromosome inactivation (representative cases: cases 3, 4, 7, 9, 12, and positive ...random inactivation of X-chromosome, which indicated palmar fibromatosis is ...
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