Xenograft models
![[18F]Fludarabine-PET as a promising tool for differentiating CNS lymphoma and glioblastoma: Comparative analysis with [18F]FDG in human xenograft models](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
[18F]Fludarabine-PET as a promising tool for differentiating CNS lymphoma and glioblastoma: Comparative analysis with [18F]FDG in human xenograft models
... lymphoma models (follicular RL7, DOHH2; multiple myeloma RPMI-8226) and under various conditions such as cancerous tissue following therapy and inflammation ...explored xenograft models of human ...
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Establishment of patient derived non small cell lung cancer xenograft models with genetic aberrations within EGFR, KRAS and FGFR1: useful tools for preclinical studies of targeted therapies
... NSCLC xenograft models from the thirty-one implantations were established in consecutive passages in nude mice (Table ...growing xenograft tissues were implanted into nude mice starting from the ...
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Antitumor activity of the multikinase inhibitor regorafenib in patient-derived xenograft models of gastric cancer
... Regorafenib induces apoptosis and central necrosis Regorafenib 10 mg/kg/day induced apoptosis in seven of the eight gastric cancer xenograft models (all p < 0.05 versus tumors from vehicle-treated ...
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Patient derived xenograft models of breast cancer and their predictive power
... patient-derived xenograft models The use of preclinical models to test hypotheses is central to cancer ...mouse models, often fail to recapitulate the key aspects of human malignancies and ...
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Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models
... cancer models after chemotherapy treatment ...same xenograft models. The models had distinct histological origin and diverse response patterns to ...
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Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation
... Next we re-evaluated gene expression differences between the melanoma subgroups at higher stringency (p<0.005 ; Student´s t-test). This analysis resulted in 191 probes representing 180 differentially expressed genes. ...
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CD47 blockade inhibits tumor progression human osteosarcoma in xenograft models
... CD47 blockade using specific antibodies increases macrophage phagocytosis of osteosarcoma tumor cells LM8 and KRIB tumor cells were labeled with carboxy fluorescein diacetate succinimidy[r] ...
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Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models
... A crucial factor for the development of a successful pretargeted system is the elimination properties of the radiotracer. Renal clearance should be favoured over the hepatobiliary excretion in order to avoid unwanted, ...
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Patient derived xenograft models in musculoskeletal malignancies
... PDX models, some have presented promising predictive value for clinical ...PDX models of RMS to identify a superior oncolytic activity of melphalan than that of frequently used drugs, which was further ...
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Establishment and evaluation of four different types of patient-derived xenograft models
... In recent years, patient derived xenografts (PDXs) have been used to evaluate targeted treatments for dif- ferent types of tumors, such as breast and non-small cell lung cancer, esophageal squamous cell carcinoma. The ...
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Leptin produced by obesity altered adipose stem cells promotes metastasis but not tumorigenesis of triple negative breast cancer in orthotopic xenograft and patient derived xenograft models
... Fig. 3 Adipose stem cells do not affect tumor growth of TNBC xenogafts, but obASCs increase metastases. a Average tumor volume of TNBC cell line BT20 xenograft was consistent for all groups across the time course ...
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Establishment of patient derived xenograft models and cell lines for malignancies of the upper gastrointestinal tract
... and models to manipulate and perform functional experiments should be generated to reflect the heterogeneity observed in the ...mouse models (GEMMs) are inadequate to mimick broad, unselected patient ...
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Patient-derived xenograft models of colorectal cancer in pre- clinical research: a systematic review
... PDX models in CRC in the published ...PDX models of CRC have doubled in the last three years (Figure ...PDX models as an intermediary to generating CRC cell-lines or colospheres is not common despite ...
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Analysis of the anti tumor effect of cetuximab using protein kinetics and mouse xenograft models
... mouse xenograft Treatment with 6 injection of cetuximab for 26 days resulted in a significant suppression of tumor growth (P < ...the xenograft tumor ...
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Current status and perspectives of patient-derived xenograft models in cancer research
... PDX models faithfully mimic human can- cers, they can be used to delineate the per se molecular, cellular, and sub-clonal characterizations of various types of ...PDX models of acute myeloid leukemia (AML) ...
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Prognostic value of the expression of cancer stem cell-related markers CD133 and CD44 in hepatocellular carcinoma: From patients to patient-derived tumor xenograft models
... Patient-derived xenograft (PDX) models are established by the transfer of fresh tumors from surgery into immunodeficient mice on the subcutaneous ...These models could overcome the obstacles in the ...
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Preclinical activity of selinexor, an inhibitor of XPO1, in sarcoma
... preclinical models of various sarcoma ...sarcoma xenograft models including gastrointestinal stromal tumor (GIST), liposarcoma (LPS), leiomyosarcoma, rhabdomyosarcoma, undifferentiated sarcomas, and ...
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Third generation EGFR inhibitor osimertinib combined with pemetrexed or cisplatin exerts long-lasting anti-tumor effect in EGFR-mutated pre-clinical models of NSCLC
... and xenograft models the combin- ation of gefitinib with pemetrexed or the intermittent combination of pemetrexed and gefitinib prevented the appearance of gefitinib resistance mediated by T790M mutation ...
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Tumor xenograft animal models for esophageal squamous cell carcinoma
... Orthotopic tumor xenograft model is an alternate ani- mal cancer model used for ESCC research. This model is established by implanting ESCC cells/xenografts in the esophagus of the immunodeficient animals to ...
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Growth inhibition of different human colorectal cancer xenografts after a single intravenous injection of oncolytic vaccinia virus GLV 1h68
... tumor xenograft models like breast can- cer [15], anaplastic thyroid carcinoma [16,17], malignant pleural mesothelioma [18], pancreatic tumor [19], prostate carcinoma [20], squamous cell carcinoma [21], ...
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