Y-box protein 1
Stable expression of Y box protein 1 gene in early development of the abalone Haliotis diversicolor
... genes, Y-box protein 1 (YB1), ornithine decarboxylase antizyme 1 (OAZ1) and eukaryotic translation initiation factor 5A (EIF5A), were found to be the most stable and could be used as ...
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Cold shock Y-box protein-1 proteolysis autoregulates its transcriptional activities
... YB-1 protein remained cytoplasmic with only a minor fraction shuttling to the nucleus (Figure ...the protein N-terminus was ...YB-1 protein was still detected peri- ...stress-dependent ...
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rSjp40 inhibits activated hepatic stellate cells by promoting nuclear translocation of YB1 and inducing BMP 7/Smad1/5/8 pathway
... morphogenic protein (BMP)-7 has recently been identified as an anti-fibrotic factor and leads to phosphoryla- tion of Smad1/5/8 in activated hepatic stellate ...activator, Y-Box ...
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Physical and Functional Interaction between the Y-Box Binding Protein YB-1 and Human Polyomavirus JC Virus Large T Antigen
... The Y-box binding proteins are the most evolutionarily con- served nucleic acid binding proteins, representing a multigene family identified in a number of organisms ranging from bac- teria to higher ...
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Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1)
... in structure of all the compounds and the fact that they were identified in both in vitro kinase assays and in silico docking to an ATP-bound RSK crystal structure is indicative of a structure-activity relationship for ...
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Transcriptional regulation of human polyomavirus JC: evidence for a functional interaction between RelA (p65) and the Y-box-binding protein, YB-1.
... crude protein extract was made by repeated cycles of freezing and ...of protein were assayed for chloramphenicol acetyltransferase (CAT) activity ...
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High expression of Y-box-binding protein 1 correlates with poor prognosis and early recurrence in patients with small invasive lung adenocarcinoma
... mammalian protein extraction kit (KW-BIO, Beijing, Peo- ple’s Republic of China) and then quantified by BCA protein assay kit (Thermo Fisher ...(diluted 1:2,000) and GAPDH (diluted 1:5,000), ...
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Akt-mediated phosphorylation controls the activity of the Y-box protein MSY3 in skeletal muscle
... file 1: Figure ...file 1: Figure ...MSY3 protein is completely de- pleted ...file 1: Figure ...MSY3 protein were distributed equally between the nuclei and cytoplasm in untreated ...
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Original Article High expression of Y-box-binding protein 1 is associated with local recurrence and predicts poor outcome in patients with colorectal cancer
... and their matched normal tissues were collect- ed between September 2013 and December 2013. For immunohistochemistry assay, a total of 170 paraffin-embedded primary CRC tissues and their matched normal tissues were ...
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Y-Box Binding Protein 1 Stabilizes Hepatitis C Virus NS5A via Phosphorylation-Mediated Interaction with NS5A To Regulate Viral Propagation
... on the serine residues examined (13, 78, 79). Since NS5A phosphorylation also regulates virion assembly (13), phosphory- lation of NS5A has been suggested to control the switch from HCV RNA replication to virus ...
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Y-Box-Binding Protein 1 Interacts with Hepatitis C Virus NS3/4A and Influences the Equilibrium between Viral RNA Replication and Infectious Particle Production
... core protein levels of the replication-defective GND JFH-1 mutant were not decreased following YB-1 knockdown (data not shown), strongly suggest- ing that YB-1 does not negatively influence ...
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The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density
... Y-box transcription factors are multifunctional regulators of gene expression and have been proposed to play a general role in promoting proliferation (Bargou et al., 1997; Matsu- moto and Wolffe, 1998). ...
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Aloe-emodin inhibits HER-2 expression through the downregulation of Y-box binding protein-1 in HER-2-overexpressing human breast cancer cells
... In recent years, much attention has been paid to the anti-tumor effect of emodin, with the main focus on neuroectodermal tumors, liver cancer, lung squamous cell carcinoma, merkel cell skin cancer, stomach cancer, and ...
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Thrombin activates a Y box–binding protein (DNA binding protein B) in endothelial cells
... nuclear protein, thrombin-inducible nuclear factor (TINF), which specifically bound an oligonucleotide corresponding to the sequence of the thrombin-response element ...
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Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y box binding protein 1 (YB 1) and can be inhibited with Iressa in basal like breast cancer, providing a potential target for therapy
... lanes 1, 5 and 10), the introduction of the nuclear extract from all cell lines produced intense bind- ing to the EGFR promoter (Figure 5b, lanes 2, 6 and 11) that could be competitively inhibited with unlabelled ...
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Serum Y Box Binding Protein 1 (YBX 1) and Interleukin 6 (IL 6) Are Associated with Metastasis in Breast Cancer Patients
... focused on evaluating its serum levels. YBX-1 is secreted through anon-classical vesicle-mediated pathway, from mesangial and monocyticcells under lipopoly- saccharide-induced inflammatory stress [23]. In 2014, ...
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Y-box binding protein 1 enhances DNA topoisomerase 1 activity and sensitivity to camptothecin via direct interaction
... Co-immunoprecipitation and GST pull-down assay Co-immunoprecipitation was performed as described previously [21]. For the interactions between endogen- ous YB-1 and TOPO1, the cytosolic or nuclear extracts (500 ...
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<p>Elevated nuclear YBX1 expression and the clinicopathological characteristics of patients with solid tumors: a meta-analysis</p>
... binding protein 1 (YBX1) is a multifunctional protein of the cold-shock superfamily which plays different roles in both nucleus and ...the Y-box sequence located in the promoter which ...
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Original Article Y-box-binding protein-1 and E-cadherin are potential prognostic factors in human bladder carcinoma
... Abstract: Many studies have reported various results regarding the relationship of Y-box binding protein 1 (YB-1) and E-cadherin with many cancers, including bladder carcinoma (BC). ...
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Kindlin-2 interacts with β-catenin and YB-1 to enhance EGFR transcription during glioma progression
... up-regulating Y-box binding protein-1 (YB-1) and β-catenin expression, Kindlin-2 formed a transcriptional complex with YB-1 and β-catenin that bound to the EGFR promoter and ...
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