YKL-40
YKL-40: a Potential Biomarker and Therapeutic Target for Breast Cancer Diagnosis and Therapy
... of YKL- 40 ...of YKL-40 in individual benign breast tissue (Figure 1A) may also implicate the genetic influence in its distinct expression ...of YKL-40 in breast cancer ...
15
Prognostic and Clinicopathological Value of the Expression of FOXC2 & YKL 40 in Carcinoma of the Breast, an Immunohistochemical Study
... distributed parameters. And Kruskal Wallis H test to compare between more than two sets of normally distributed parameters. We have used Pearson’s Chi-square test or Fisher’s exact test to compare percent of categorical ...
20
Prognostic value of YKL-40 in solid tumors: a meta-analysis of 41 cohort studies
... serum/plasma YKL-40 in solid tumors, such as gastrointestinal tumors, ovarian cancer, melanoma, lung cancer, urologic neo- plasms, glioblastoma, breast cancer, squamous cell car- cinoma of the head and neck ...
15
HUMAN CARTILAGE GLYCOPROTEIN 39 (YKL 40): A VIEW IN TYPE 2 DIABETES MELLITUS
... Plasma YKL-40 was assessed by ELISA method and routine investigations was done fully automated ...Plasma YKL-40 was significantly increased in diabetic patients compared with ...Plasma ...
5
<p>Overexpression of chitotriosidase and YKL-40 in peripheral blood and sputum of healthy smokers and patients with chronic obstructive pulmonary disease</p>
... and YKL-40 increase with ...and YKL-40 levels and reduced lung function, which has been previously reported in COPD studies assessing chitinases expression in peripheral ...
21
Neutrophil-to-lymphocyte ratio, calprotectin and YKL-40 in patients with chronic obstructive pulmonary disease: correlations and 5-year mortality – a cohort study
... of YKL-40 (also named CHI3L1) is another potential biomarker of inflammatory activity in patients with ...Plasma YKL-40 is elevated, compared to normal levels, in patients with diseases ...
12
Plasma YKL-40 and all-cause mortality in patients with chronic obstructive pulmonary disease
... of YKL-40 is known [18]. YKL- 40 is mainly secreted by cancer cells, macrophages, and neutrophils ...that YKL-40 plays a role in cell proliferation and differentiation [20], ...
10
Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer’s disease
... CSF YKL-40 in early stages of AD have been demonstrated in two independent studies, but there are also contradictory data [28, 32, ...that YKL-40 is elevated early in the course of AD and that ...
8
Plasma YKL-40 and NGAL are useful in distinguishing ACO from asthma and COPD
... [21]. YKL-40, originally shown to be an upstream cytokine that drives dendritic cells to enhance Th2 polarization in asthmatic patients [20, 22], is now found to be more related with remodeling and more ...
10
Urine YKL-40 is associated with progressive acute kidney injury or death in hospitalized patients
... summary, YKL-40 is a repair-phase protein that is de- tectable in urine on the first day of clinically apparent AKI and provides only modest prognostic potential on its ...combining YKL-40 ...
9
In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases
... (HC-gp39), YKL-40, gp38k, chondrex, breast regression protein 39 (BRP-39)) is up-regulated in inflamed tissues in ulcerative colitis, Crohn's disease, rheumatoid arthritis, osteoarthritis, asthma, chronic ...
8
Chitinase-like protein YKL-40 correlates with inflammatory phenotypes, anti-asthma responsiveness and future exacerbations
... Firstly, YKL-40 levels were measured only once during the one-year co- hort study, which led that we could not explore whether serum YKL-40 level was an invariant characteristic des- pite ...
12
Cerebrospinal fluid levels of glial marker YKL-40 strongly associated with axonal injury in HIV infection
... Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is a receptor glycoprotein belonging to the im- munoglobulin superfamily. It is more specific for activa- tion of microglia and macrophages than ...
9
Original Article Serum YKL-40 levels and risk factors of cardiovascular disease in Saudi patients with essential hypertension
... Abstract: YKL-40 has been suggested to be a potential biomarker of inflammation and endothelial ...serum YKL-40 levels and some risk factors of cardiovascular diseases (CVD) in essential ...
12
YKL 40 is highly expressed in the epicardial adipose tissue of patients with atrial fibrillation and associated with atrial fibrosis
... follows: YKL-40 (CHI3L1), forward 5 ′ -GTG AAG GCG TCT CAA ACA GG-3 ′ , reverse 5 ′ -GAA GCG GTC AAG GGC ATC T-3 ′ ; collagen I (COL1A1), forward 5 ′ -CCA AGA CGA AGA CAT CCC ACC-3 ′ , reverse 5 ′ -CAG TTG ...
9
Airway, but not serum or urinary, levels of YKL-40 reflect inflammation in early cystic fibrosis lung disease
... of YKL-40 in BAL and serum were not associ- ated with age at time of BAL, sex, initial presentation with meconium ileus or regular antibiotic prophylaxis (data not ...Serum YKL-40, but not BAL ...
6
YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer’s disease and other tauopathies
... is YKL-40 (also named Chitinase 3-like I) [7, ...that YKL-40 participates in connective tissue cell growth, endothelial cell migration and inhib- ition of mammary epithelial cell ...
10
TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells
... In conclusion, we revealed the essential role of exosomes in communication between cancer cells and surrounding stroma and demonstrated that TrkB expression in exosomes is required for inducing aggressiveness phenotype. ...
16
YKL-40 expression in chronic obstructive pulmonary disease: relation to acute exacerbations and airway remodeling
... serum YKL-40 levels were increased in severe asthma patients and were correlated positively with the thickness of the subepithelial basement membrane [8, ...of YKL-40 was involved in tissue ...
11
CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development
... previous prospective study [6], we diagnosed asthma based on one definition and assessed further outcomes on respiratory health (lung function at 5 weeks and 6 years, respiratory symptoms during the first year). ...
9