Zaire ebolavirus
Comparison of FilmArray and Quantitative Real Time Reverse Transcriptase PCR for Detection of Zaire Ebolavirus from Contrived and Clinical Specimens
... whole blood and urine (10, 11). The apparent differences likely have more to do with variations in the harshness of the protocols used to inactivate the virus in the analyte preparations than the ability of the test ...
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The Tyro3 Receptor Kinase Axl Enhances Macropinocytosis of Zaire Ebolavirus
... Axl, a plasma membrane-associated Tyro3/Axl/Mer (TAM) family member, is necessary for optimal Zaire ebolavirus (ZEBOV) glycoprotein (GP)-dependent entry into some permissive cells but not others. To date, ...
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In Silico Design of a Potent siRNA Molecule for Gene Silencing in Zaire Ebolavirus
... The aim of the study was to find a siRNA target sequence site for mRNA coding for protein L in Zaire ebolavirus. The mRNA sequence and other information regarding the nucleotide sequence were obtained from ...
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Expression of microRNA in human retinal pigment epithelial cells following infection with Zaire ebolavirus
... Zaire ebolavirus causes uveitis in EVD survivors [26, 27]. We have identified miRNAs produced in human RPE cells following infection with EBOV. Viruses take advantage of host miRNAs to adjust gene ...
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Bioinformatics Analysis of Garcinia Kola Active Components and Glycoproteins of Ebola Virus (Zaire ebolavirus)
... in Zaire in ...(the Zaire, Sudan, Tai Forest, Bundibugyo, and Reston viruses), which differ in their virulence for ...species, Zaire ebolavirus seems to be the most virulent, with a case ...
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Ebolavirus diagnosis made simple, comparable and faster than molecular detection methods: preparing for the future
... The Ebolavirus outbreak dominated international news in 2014 and the World Health Organization reported more than 28,000 cases worldwide and over 11,000 deaths ...of Ebolavirus outbreaks [6], based on the ...
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Ebola virus disease: from epidemiology to prophylaxis
... The outbreak of Ebola virus disease (EVD) continues to spread through West Africa. Since the first report of EVD in March 2014, the number of cases has increased rapidly, with the fatality rate of >50%. The most ...
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Ebola Virus and its Mechanism in Fatal Disease Formation
... of Zaire ebolavirus (ZEBOV) and Sudan ebolavirus (SEBOV) in a single complex adenovirus-based vector (CAdVax) and showed potential protection of non-human primates against those ebolaviruses (Pratt, ...
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Ebolavirus in West Africa, and the use of experimental therapies or vaccines
... of ebolavirus hemorrhagic fever (EHF) [1], lately also referred to as Ebola virus disease (EVD), has led to a surge in public interest and concern regarding this virus, which was first discovered in 1976 during ...
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Ebolavirus Entry: From Molecular Characterization to Drug Discovery
... genus Ebolavirus of the Filoviridae family includes five species: Bundibugyo ebolavirus, Reston ebolavirus, Sudan ebolavirus, Tai Forest ebolavirus, and Zaire ...the Zaire ...
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Serological evidence of ebolavirus infection in bats, China
... of ebolavirus have been identi- fied: Ivory Coast ebolavirus, Sudan ebolavirus, Zaire ebolavirus (EBOV), Reston ebolavirus (RESTV) and Bun- dibugyo ...of ebolavirus in ...
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Determination of Specific Antibody Responses to the Six Species of Ebola and Marburg Viruses by Multiplexed Protein Microarrays
... Infectious hemorrhagic fevers caused by the Marburg and Ebola filoviruses result in human mortality rates of up to 90%, and there are no effective vaccines or therapeutics available for clinical use. The highly ...
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AMP-Activated Protein Kinase Is Required for the Macropinocytic Internalization of Ebolavirus
... for Zaire Ebolavirus (EBOV) entry provides insights into the mechanism(s) of filovirus uptake, and these factors may serve as potential antiviral ...
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Characterization of Influenza Virus Pseudotyped with Ebolavirus Glycoprotein
... outbreak, Zaire ebolavirus was first isolated and characterized (3, ...identified: Zaire, Sudan, Taï Forest, Bundibugyo, and Reston ebolavirus ...
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Identity and validity of conserved B cell epitopes of filovirus glycoprotein: towards rapid diagnostic testing for Ebola and possibly Marburg virus disease
... genus Ebolavirus, on the other hand, first emerged in 1976 as the causative agent of two simultaneous VHF outbreaks in southern Sudan and northern Zaire [1, ...genus Ebolavirus, four of which are ...
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Filoviruses in Bats: Current Knowledge and Future Directions
... Reston ebolavirus has been isolated from captive primates (Macaca fascicularis) in the Philippines (131/1051 were antigen positive) ...like Zaire ebolavirus, Reston virus has caused disease and ...
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High prevalence of IgG antibodies to Ebola virus in the Efé pygmy population in the Watsa region, Democratic Republic of the Congo
... had Zaire ebolavirus species as source of ...cross-species ebolavirus antibodies ...cross-reactive ebolavirus species in the study ...unknown ebolavirus species of lower pathogenicity, ...
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Positive Impact Program Evaluation
... The third epidemic in Zaire ebolavirus in Gabon occurred in Booue area. Virus was isolated from two of six samples from patients hospitalized at Booue (Georges, et al., 1999). A retrospective study of the ...
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The face of Ebola: changing frequency of haemorrhage in the West African compared with Eastern Central African outbreaks
... (WA) Zaire Ebolavirus disease (EVD) outbreak was characterized by an exceptionally high number of cases and deaths as compared with the Eastern-Central African (ECA) ...the Zaire Ebolavirus ...
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Novel functional hepatitis C virus glycoprotein isolates identified using an optimised viral pseudotype entry assay
... replicating molecular clone JFH-1 and chimeras derived from this virus possessing the structural genes of other viruses pro- vide a method of assessing neutralization of small panels of genetically diverse viruses ...
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