Zebrafish models
Attenuation of Anxiety Behaviours by Xylopic Acid in Mice and Zebrafish Models of Anxiety Disorder
... reduced latency to feeding in mice in the hyponeophagia test for anxiety and also significantly reduced thigmotaxis in the OFT at 30 mg kg -1 (P<0.001). All mice given xylopic acid significantly spent more time in the ...
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New zebrafish models of neurodegeneration
... mutant zebrafish and demonstrated lack of clp1 mRNA expression, a reduction in expression of the otx2 midbrain marker and an increase in midbrain and hindbrain TUNEL stain which indicates cell death, both of which ...
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Exploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish models
... The zebrafish has well-conserved Hif-1 α , Hif-2 α and Hif-3 α variants and given its genetic tractability and the range of diseases that can be modelled, it offers an opportunity to understand the interplay ...
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Zebrafish Models in Neural and Behavioral Toxicology across the Life Stages
... The industry is increasingly relying on fish for toxicity assessment. However, current guidelines for toxicity assessment focus on teratogenicity and mortality. From an ecotoxicological point of view, however, these ...
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Vitamin K reduces hypermineralisation in zebrafish models of PXE and GACI
... start codon of the abcc6a gene via BAC recombineering (Bussmann and Schulte-Merker, 2011). The mosaic expression of Tg(abcc6a: gal4;uas:gfp) at 7 dpf revealed GFP in the notochord and in cells near the operculum and ...
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Evaluation and characterisation of two zebrafish models of schizophrenia
... As zebrafish satiate rapidly after a short period of feeding, it was expected that the fish would complete more trials per session when reinforced with social ...
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Zebrafish: An in Vivo Model for the Study of Human Diseases
... characterized zebrafish model of Non-alcoholic fatty liver disease (NAFLD) involved a forward genetic screen using viral insertion and screening for ...discovered zebrafish gene foie gras (foigr) [56], ...
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Transcriptome analysis reveals a ribosome constituents disorder involved in the RPL5 downregulated zebrafish model of Diamond-Blackfan anemia
... DBA zebrafish models (such as RPS19 MO zebrafish, RPS24 MO zebrafish, and RPL11 MO zebrafish), these differentially expressed genes showed RPL5 MO had some general characters and little ...
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Three-dimensional reconstruction and measurements of zebrafish larvae from high-throughput axial-view in vivo imaging
... the zebrafish larvae in our ...the zebrafish for the di ff erent larval stages; i.e. as the zebrafish grow, the VRV ...identical zebrafish specimen in Fig. 9. For a ASD of 4 or 7, the 3D ...
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A Comprehensive Study of High Cholesterol Diet-Induced Larval Zebrafish Model: A Short-Time In Vivo Screening Method for Non-Alcoholic Fatty Liver Disease Drugs
... larval zebrafish models we built above and the multiple test we performed, we believed the mort- ality, TC levels, TG levels and nile red stain could be the index of lipid metabolism for drug screening; The ...
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Analysis of myostatin gene structure, expression and function in zebrafish
... as zebrafish, guppies and other fish that remain small (Van Raamsdonk et ...in zebrafish could be due to the lack of mosaic hyperplasia in ...transgenic zebrafish only grow 20% faster than ...
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Image analysis in light sheet fluorescence microscopy images of transgenic zebrafish vascular development
... The zebrafish has become an established model to study vas- cular development and disease in ...of zebrafish neurovascular ...of zebrafish neurovasculature de- ...
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Transcriptome dynamics in early zebrafish embryogenesis determined by high-resolution time course analysis of 180 successive, individual zebrafish embryos.
... in zebrafish embryogenesis from late blastula to mid-gastrula is tightly regulated and gene-expression changes are in general gradual with small fold ...early zebrafish embryogenesis that we also made ...
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FREQUENCY OF γ-RAY INDUCED SPECIFIC LOCUS AND RECESSIVE LETHAL MUTATIONS IN MATURE GERM CELLS OF THE ZEBRAFISH, BRACHYDANIO RERIO
... Comparison of zebrafish and mouse mutagenesis: The frequency of mutations induced in zebrafish eggs or sperm appears to be higher than reported for any germ line stages in the m[r] ...
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Abstract: Though the cancer research community has used mouse xenografts for decades more than
... events. Zebrafish are part of the teleost radiation that followed a whole genome duplication in the common ancestor to the teleosts ...in zebrafish are duplicated when compared to their mammalian ...
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Reciprocal endoderm mesoderm interactions mediated by fgf24 and fgf10 govern pancreas development
... In mouse, the mesenchyme surrounding the dorsal pancreatic bud is characterized by the expression of isl1 and fgf10 genes (Ahlgren et al., 1997; Bhushan et al., 2001). Also, strong expression of the murine meis genes, ...
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Development of the acoustically evoked behavioral response in zebrafish to pure tones
... of zebrafish is also similar to goldfish (Platt, 1993), and leads to the expectation that zebrafish will have similar hearing capabilities as ...adult zebrafish, and adult goldfish. They found that ...
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Slow calcium waves mediate furrow microtubule reorganization and germ plasm compaction in the early zebrafish embryo
... Zebrafish germ plasm ribonucleoparticles (RNPs) become recruited to furrows of early zebrafish embryos through their association with astral microtubules ends. During the initiation of cytokinesis, ...
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Zebrafish embryo, a tool to study tumor angiogenesis
... molecules, zebrafish allows disease-driven drug target identification and in vivo validation, thus representing an interesting bioassay tool for small molecule testing and dissection of biological pathways ...
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The role of the homeodomain protein Bozozok in zebrafish axis formation
... in zebrafish gastrula, the lateral but not dorsal blastoderm margin exerts a posteriorizing influence upon transplantation into the prospective forebrain region (Woo and Fraser, ...the zebrafish gastrula ...
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