Zinc-Finger Proteins
An affinity-based scoring scheme for predicting DNA-binding activities of modularly assembled zinc-finger proteins
... Zinc-finger proteins (ZFPs) have long been recog- nized for their potential to manipulate genetic infor- mation because they can be engineered to bind novel DNA ...Individual ...
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Identification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteins
... TOPK/PBK is an oncogenic kinase upregulated in most human cancers and its high expression correlates with poor prognosis. TOPK is known to be activated by Cdk1 and needed for mitotic cell division; however, its mitotic ...
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Inhibition of Virus DNA Replication by Artificial Zinc Finger Proteins
... artificial proteins), rapid evolution of viruses to inactivate AZPs seems to be ...replication proteins and DNA sequences of the binding sites of the emerging mu- tant proteins in their replication ...
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Zinc finger proteins in early Xenopus development
... Int J De\' BioI 40 291 295 (1996) 291 Zinc finger proteins in early Xenopus development THOMAS HOLLEMANN, ERIC BELLEFROID, REIMER STICK and TOMAS PIELER* Georg August Universitat Gdttingen, Institut f[.] ...
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Live cell imaging of repetitive DNA sequences via GFP-tagged polydactyl zinc finger proteins
... on zinc finger-DNA recognition ...polydactyl zinc finger (PZF) DNA-binding domains aimed to recog- nize specific DNA sequences in Arabidopsis and mouse and fused these with ...PZF:GFP ...
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Inhibition of DNA Replication of Human Papillomavirus by Artificial Zinc Finger Proteins
... artificial zinc finger protein (AZP) that was designed to block binding of the replication protein (Rep) to its repli- cation origin, and transgenic Arabidopsis thaliana plants ex- pressing the AZP showed ...
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Allosteric Inhibition of Zinc Finger Proteins by DNA Binding Polyamides
... isotherms represent binding at the match target site in the minor groove, which has the sequence shown in the lower right panel of the figure, and which overlaps [r] ...
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KRAB zinc finger proteins
... ERV-derived proteins can themselves be sources of genetic diversity, as illustrated in placental mammals in which formation of the syncytiotrophoblast, a placenta layer with extensive cellular fusion, is mediated ...
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Zinc finger proteins in cancer progression
... conserved zinc finger motifs, is found acetylated at the lysine residues adjacent to the C terminal zinc finger by acetyltransferase CBP and ...its zinc finger motif mediated by ...
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Zinc Finger Transcription Factors as Molecular Targets for Nitric Oxide-mediated Immunosuppression: Inhibition of IL-2 Gene Expression in Murine Lymphocytes
... In conclusion, inhibition of the DNA binding activities of transcription factors such as the zinc finger proteins Spl and EGR-1 appears to be a molecular mechanism for the inhibition of [r] ...
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Comparative analysis of the genetic variability within the Q-type C2H2 zinc-finger transcription factors in the economically important cabbage, canola and Chinese cabbage genomes
... C2H2 zinc finger proteins (ZFP) are transcrip- tion ...the zinc finger domains, and C2H2 characterizes the two cysteine and two histidine residues found in each ...a zinc ion ...
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Analysis of the interaction between Zinc finger protein 179 (Znf179) and promyelocytic leukemia zinc finger (Plzf)
... kruppel-like zinc fingers ...and zinc-finger proteins, and has been shown to mediate homo/heterodimerization, nuclear localization as well as to direct binding of corepressors ...
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Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family
... C2H2-type zinc finger proteins (ZFPs) constitute the largest transcription factor family in ...multiple zinc finger domains that allow high flexibility and specificity in target ...the ...
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A novel combination of bortezomib, lenalidomide, and clarithromycin produced stringent complete response in refractory multiple myeloma complicated with diabetes mellitus – clinical significance and possible mechanisms: a case report
... revealed that Len’s multiple effects include: (1) immune modulation (CD4+ and CD8+ T cell co-stimulation, regu- latory T cell suppression, Th1 cytokine production, NK and NKT cell activation, and antibody-dependent ...
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Development of neurodevelopmental disorders: a regulatory mechanism involving bromodomain-containing proteins
... WSTF including the nucleosome assembly complex (WINAC) is another SWI/SNF-type complex that has ATP-dependent chromatin-remodeling activity. It interacts with the vitamin D receptor (VDR) through the Williams syndrome ...
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The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis
... binding proteins or even intramolecular folding events; third, the protein was phosphorylated by one or more protein kinases that were either slowly activated by LPS or whose biosynthesis was also stimulated by ...
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Structure of Arabidopsis HISTONE DEACETYLASE15
... The zinc finger domain enhances HDA15HD dimerization and enzymatic. 796[r] ...
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Importance of Basic Residues in the Nucleocapsid Sequence for Retrovirus Gag Assembly and Complementation Rescue
... Gag proteins. For example, myristate-minus Gag proteins of M-PMV are still able to associate into cyto- plasmic cores (24) and studies with myristylation inhibitors have shown that HIV particles can form ...
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The transcriptional foundation of pluripotency
... native proteins that can have significant differences in their affinity and may have differential access to epitopes present in multi-protein ...of proteins studied by each approach (Table ...the ...
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Human Immunodeficiency Virus Type 1 Incorporated with Fusion Proteins Consisting of Integrase and the Designed Polydactyl Zinc Finger Protein E2C Can Bias Integration of Viral DNA into a Predetermined Chromosomal Region in Human Cells
... six-zinc finger E2C, constructed by grafting the amino acid residues of each zinc finger involved in specific DNA recognition into the framework of the designed consensus pro- tein Sp1C, a ...
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