Zinc Transporter
Emerging Role of Zinc Transporter-8 Autoantibodies (ZnT8A) in Type 1 Diabetes Mellitus- A Review
... as zinc transporter 8 (ZnT8), islet amyloid polypeptide, chromogranin A and pancreatic duodenal homeobox ...T1DM, zinc transporter 8 autoantibody (ZnT8A) is lately identified as another major ...
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The zinc transporter Zip7 is downregulated in skeletal muscle of insulin resistant cells and in mice fed a high fat diet
... The zinc transporter Zip7 modulates zinc flux and controls cell signaling molecules associated with glucose metabolism in skeletal ...this zinc transporter on several genes implicated ...
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Expression of zinc transporter family genes in Dictyostelium
... Putative zinc transporters in Dictyostelium. (A) A phylogenetic tree of zinc transporter family genes in ...Putative zinc transporters, the ZIP subfam- ily, the CDF subfamily, and the LZT-like ...
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Characterizing the SLC39A14 zinc transporter and collagen products of the chondrocytes from the human umbilical cord-derived mesenchymal stromal cell
... Figure 3. The chondrocyte under Immunofluorescence microscopy showed: (A) Positive for SLC39A14 staining with Anti SLC39A14 alexafluor green filter (40 x magnification); (B) Positive for nucleus staining with DAPI-blue ...
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A role for the Drosophila zinc transporter Zip88E in protecting against dietary zinc toxicity
... dietary zinc content. The Drosophila zinc transporter Zip88E shows strong sequence similarity to Zips ...ila zinc uptake transporters to facilitate dietary zinc absorption by importing ...
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Original Article Zinc transporter 1 (ZnT1) is overexpressed in bladder cancer and promotes the proliferation and invasion of bladder cancer BIU87 cells
... decreased Zinc levels were observed in the serum and tissue samples of patients with cancers of liver, gallbladder, digestive tracts and prostate gland ...[6-10]. Zinc transport- er 1 (ZnT1) is a member of ...
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Zinc transporter-1 concentrates at the postsynaptic density of hippocampal synapses
... labile zinc (Zn 2+ ) in central neu- rons might be important in a range of physiological and pathological ...of zinc transporter pro- teins, Slc30a (ZnT1-10) and Slc39 ...
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Zinc transporter-3 [SLC30A3 (rs11126936)] polymorphism is associated with major depressive disorder in Asian subjects
... The zinc transporter-3 protein, encoded by the ZnT3 (SLC30A3) gene, maintains zinc- glutamate homeostasis at the glutamatergic synapse, a disruption of which increases risk of ...
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Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup
... ZIP7 zinc transporter, which is the human ZIP protein family member most closely related to Drosophila Catsup, mediates the release of zinc from the ER and Golgi (Taylor et ...
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Targeting the Zinc Transporter ZIP7 in the Treatment of Insulin Resistance and Type 2 Diabetes
... for zinc and the protein transporters of this metal ion in ER stress and apoptosis ...[5]. Zinc is an essential metal ion that is critical for maintaining cellular function and homeostasis [6] and ...
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Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis?
... In islets there was no change over time for IFN-J stimula- tion, whereas ZnT6 and ZnT8 showed significant changes over time for both IL-1E and the stimulation with IL-1E+ IFN-J (table 3). There were significant ...
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Crystallization and preliminary X ray diffraction analysis of a soluble domain of the putative zinc transporter CzrB from Thermus thermophilus
... CzrB is a putative zinc transporter from Thermus thermophilus. The protein is proposed to consist of a hexahelical transmembrane domain with a cytosolic extramembranal C-terminus. The latter 92-residue ...
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MicroRNA-488 regulates zinc transporter SLC39A8/ZIP8 during pathogenesis of osteoarthritis
... ( A ) Human articular chondrocytes isolated from biopsy normal cartilage were treated with 10 ng/ml IL-1 β in the presence of miR-488 or miR-488 inhibitor (anti-miR-488), stained with ph[r] ...
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The zrfA and zrfB Genes of Aspergillus fumigatus Encode the Zinc Transporter Proteins of a Zinc Uptake System Induced in an Acid, Zinc-Depleted Environment
... environmental zinc concentration has also been de- scribed for the ZRT1 and ZRT2 genes from ...under zinc-limiting ...low-affinity zinc uptake systems, respectively, of ...in zinc uptake, the ...
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Zinc transporter Slc39a8 is essential for cardiac ventricular compaction
... during heart development. The extracellular matrix (ECM) that separates endocardium from myocardium plays a critical but poorly understood role in ventricular trabeculation and compaction. In an attempt to characterize ...
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The Vacuolar Zinc Transporter TgZnT Protects Toxoplasma gondii from Zinc Toxicity
... expected molecular weight of 77 kDa (Fig. 3D), similar to what was observed with TgZnT-HA (Fig. 2B). We also performed immunofluorescence assays (IFAs) using poly- clonal anti-TgZnT, which showed the labeling of two large ...
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Csr1/Zap1 Maintains Zinc Homeostasis and Influences Virulence in Candida dubliniensis but Is Not Coupled to Morphogenesis
... of zinc by Candida dubliniensis, an emerging pathogen closely related to Candida ...regulate zinc uptake mechanisms under zinc limitation: it governs the expression of the zinc ...
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Specificity of the Metallothionein-1 Response by Cadmium-Exposed Human Urothelial Cells
... Preliminary investigation into the effect of cadmium exposure on zinc homeostasis in normal urothelial cells revealed an upregulation of the zinc transporter-1 SLC30A1 gene transcript in[r] ...
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TNF-α gene expression is increased following zinc supplementation in type 2 diabetes mellitus
... by zinc transporter and MT gene expres- ...these zinc transporters are likely to be involved in either increasing cytoplasmic zinc concentration or the transport of zinc into the golgi ...
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Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia
... granule zinc transporter SLC30A8/ZnT8, identified in GWA studies for T2D [6], this approach has been pivotal in highlight- ing the role of the transporter in the control of secretory granule ...
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