Zinc Transporters
Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis?
... of zinc homeostasis is ensured by zinc trans- porters assigned to two metal transporter families: the ZIP proteins (SLC39a) and the ZnT proteins ...of zinc to the cytosol from the outside of cells or ...
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Zinc-induced upregulation of metallothionein (MT)-2A is predicted by gene expression of zinc transporters in healthy adults
... of zinc supplementation or depletion on the regulation of selected zinc transporters and MT in ...to zinc depletion or supplementation; for instance, MT and ZnT1 expressions decreased ...
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Functional studies of Drosophila zinc transporters reveal the mechanism for zinc excretion in Malpighian tubules
... mammalian zinc transporters in the Zip and ZnT family include seven potential ZnT and ten Zip proteins ...Drosophila zinc transporters for their roles in dietary zinc absorption, ...
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Altered expression of two zinc transporters, SLC30A5 and SLC30A6, underlies a mammary gland disorder of reduced zinc secretion into milk
... of zinc deficiency in breastfed neonates were investigated where zinc levels in the moth- ers’ milk were reduced by more than 75 % compared to ...maternal zinc deficiency ...the zinc ...
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Effect of ZnO nanoparticle on cell viability, zinc uptake efficiency, and zinc transporters gene expression: a comparison with ZnO and ZnSO4
... lar zinc is deleterious and poisonous to the ...maintaining zinc level in an appropriate variation range in tissue is of great ...result, zinc metabolism is tightly regulated. Zinc homeostasis ...
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Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease
... for zinc containing approximately 60% of total whole-body zinc ...reduced zinc levels leads to changes associated with the phosphorylation status of the insulin receptor substrates directly, or if ...
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The Emerging Role of the LIV-1 Subfamily of Zinc Transporters in Breast Cancer
... ZIP zinc transporters consists of nine human se- quences that share considerable homology across transmembrane ...transport zinc and/or other ions across cell ...zinc transporters. We ...
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Zinc transporters in Alzheimer’s disease
... brain zinc dyshomeostasis may play a critical role in AD progression, which provides encouraging clues for metal-targeted therapies in the treatment of ...of zinc chelator and/or ionophore strategy, such as ...
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HIV-1 transgene expression in rats induces differential expression of tumor necrosis factor alpha and zinc transporters in the liver and the lung
... of zinc status in the livers of wild type and HIV-1 transgenic ...binds zinc and is usually increased when zinc levels are ...parallel, zinc transporters tightly regulate the movement ...
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Zinc transporters are differentially expressed in human non-small cell lung cancer
... that zinc (Zn) and Zn transporters were associated with the development and progression of human ...Zn transporters including ZIPs and ZnTs in lung cancer, however, has never been ...Zn ...
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The role of metallothionein in zinc homeostasis
... ‘sense’ zinc levels significantly changed the understanding of zinc ...These zinc-sensing proteins are transcription factors that can alter the expression of zinc transporters and ...
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Functional studies of Drosophilazinc transporters reveal the mechanism for dietary zinc absorption and regulation
... of zinc from the midgut enterocytes for systemic ...for zinc uptake into the ...mediates zinc uptake, we knocked down individually each of these putative zinc transporters, both ...
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ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942.
... The CDK7 inhibitors (CDK7i) ICEC0942 and THZ1, are promising new cancer therapeutics. Resistance to targeted drugs frequently compromises cancer treatment. We sought to identify mechanisms by which cancer cells may ...
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Host Cell Copper Transporters CTR1 and ATP7A are important for Influenza A virus replication
... Copper handling machinery is evolutionarily con- served throughout eukaryotes, and copper homeostasis is recognized as important in human health. Copper transport machinery has been identified as important in macrophage ...
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12-12-2014 The ins and outs of metal homeostasis by the root nodule actinobacterium Frankia
... Being structurally analogous to phosphate, arsenate enters the cells through phosphate uptake transporters and acts as a metabolic poison [100]. Arsenate resistance involved the reduction of arsenate to arsenite, ...
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Expression of membrane transporters in cane toad Bufo marinus oocytes
... other transporters tested, rendering it more sensitive to endogenous RNAase H activity in ...other transporters tested, making it more susceptible to RNA degradation (Markovich et ...
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Molecular mechanisms of phosphate and sulphate transport in plants
... sulphate transporters to be delegated probable ...phate transporters, Hawkesford and colleagues [33] have classi¢ed these proteins into their ...these transporters are expressed in the root tip and ...
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Seasonal upregulation of fatty acid transporters in flight muscles of migratory white throated sparrows (Zonotrichia albicollis)
... Lipid transporters in a migratory bird H-FABP we hypothesized that, if birds had similar membrane fatty acid transporters to mammals, seasonal increases in their expression could be cruc[r] ...
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Cathepsin K in lymphangioleiomyomatosis: LAM cell fibroblast Interactions enhance protease activity by extracellular acidification
... Inhibition of membrane transporters affects 621-101 cell extra-cellular pH and cathepsin K activity.. We then used pharmacological inhibitors of these membrane transporters to determine [r] ...
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Comparison of two forms of daily preventive zinc supplementation versus therapeutic zinc supplementation for diarrhea on young children’s physical growth and risk of infection: study design and rationale for a randomized controlled trial
... prevent zinc deficiency, a separate set of treatment stu- dies has found that therapeutic zinc supplementation admin- istered during episodes of diarrhea decreases the duration of illness among children ...
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