[PDF] Top 20 Abnormal properties of an immediate early polypeptide in cells infected with the herpes simplex virus type 1 mutant tsK.
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Abnormal properties of an immediate early polypeptide in cells infected with the herpes simplex virus type 1 mutant tsK.
... 29:275-284, 1979 have shown that the herpes simplex virus type 1 HSV-1 mutant tsK has a temperature-sensitive lesion in an immediate early polypeptide whose function is to induce synthes[r] ... See full document
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Evidence that the Immediate-Early Gene Product ICP4 Is Necessary for the Genome of the Herpes Simplex Virus Type 1 ICP4 Deletion Mutant Strain d120 To Circularize in Infected Cells
... on infected cell lysates from the d120-infected Vero cells and the d120- infected E5 cells that produce ICP4 polypeptide upon infection of HSV-1 (25), as detailed in ... See full document
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Repression of gene expression upon infection of cells with herpes simplex virus type 1 mutants impaired for immediate-early protein synthesis.
... Vero cells which had been transformed to G418 resistance by transfection of a plasmid containing the npt gene controlled by the ICP0 promoter ...3). Cells were infected with in1331 and coinfected ... See full document
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Control of VP16 Translation by the Herpes Simplex Virus Type 1 Immediate-Early Protein ICP27
... in cells infected with HSV vari- ants lacking ...Fig. 1. Vero cells were either mock infected or infected for 12 h with the wild-type ...KOS1.1 virus or the ICP27- ... See full document
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Binding of ICP4, TATA-Binding Protein, and RNA Polymerase II to Herpes Simplex Virus Type 1 Immediate-Early, Early, and Late Promoters in Virus-Infected Cells
... DNA-binding properties but delete the amino- and carboxyl-terminal activation re- ...a mutant (n208) that is truncated at amino acid 774, thereby deleting the carboxyl-terminal 524 amino ... See full document
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Herpes simplex virus mutants defective in the virion-associated shutoff of host polypeptide synthesis and exhibiting abnormal synthesis of alpha (immediate early) viral polypeptides.
... The vhs mutants appeared to be defective also with respect to post-transcriptional shutoff of a immediate early viral gene expression, since i cells infected with mutant viruses overprod[r] ... See full document
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Recruitment of Herpes Simplex Virus Type 1 Immediate-Early Protein ICP0 to the Virus Particle
... the mutant viruses shown in Fig. 8A, together with the ⌬ ICP0 mutant virus dl1403, and ICP0 and VP22 levels were compared to that present in Wt (s17) ...ICP0 mutant virus indicated that ... See full document
15
Herpes Simplex Virus Type 1 Induces CD83 Degradation in Mature Dendritic Cells with Immediate-Early Kinetics via the Cellular Proteasome
... were infected according to our standard infection ...UV-inactivated virus was no longer able to downmodulate ...FIG. 1. CD83 is downregulated from the infected mDC surface with fast kinetics ... See full document
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Long-Term Transgene Expression in Mice Infected with a Herpes Simplex Virus Type 1 Mutant Severely Impaired for Immediate-Early Gene Expression
... VP16 mutant (in1851), which is unable to replicate in neurons due to an insertion that disrupts the TK coding sequences (12), since the number of -galactosidase-positive neurons after inoculation with in1388 is ... See full document
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Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells.
... To examine the role of ICPO in the regulation of viral gene expression during productive infection, we characterized the wild-type virus, an ICPO null mutant 7134, and several ICPO nonse[r] ... See full document
12
Overexpression of the herpes simplex virus type 1 immediate-early regulatory protein, ICP27, is responsible for the aberrant localization of ICP0 and mutant forms of ICP4 in ICP4 mutant virus-infected cells.
... are immediate-early regulatory proteins of herpes simplex virus type ...wild-type virus-infected cells but predominantly in the cytoplasms of ... See full document
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The herpes simplex virus type 1 immediate-early protein ICP0 is necessary for the efficient establishment of latent infection.
... The immediate-early protein ICP0 of herpes simplex virus type 1 (HSV-1) plays an important regulatory role during viral infection in cultured cells and in ... See full document
9
Phenotype of the herpes simplex virus type 1 protease substrate ICP35 mutant virus.
... Phenotypic analysis of AICP35 shows that i mutant virus growth in Vero cells was severely restricted, although small amounts of progeny virus were produced; ii full-length ICP35 protein [r] ... See full document
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Neurons differentially control expression of a herpes simplex virus type 1 immediate-early promoter in transgenic mice.
... Herpes simplex virus (HSV) infections lead to a variety of diseases in humans; these may include recurrent genital and orofacial lesions, keratitis, conjunctivitis, encephalitis, and dis- seminated ... See full document
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The null mutant of the U(L)31 gene of herpes simplex virus 1: construction and phenotype in infected cells.
... codons 1 to 163 was cloned into an Escherichia coli anthranilate synthetase (TrpE) expression vector (22). The fusion protein was induced after 2-h log- phase growth of transformed E. coli with 20 m g of ... See full document
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The range and distribution of murine central nervous system cells infected with the gamma(1)34.5- mutant of herpes simplex virus 1.
... HSV-infected cells in the locus ...one infected neuronal cell is evident (lower arrow), whereas the integrity and nature of other immunostained cells (upper arrow) or cell debris in this ... See full document
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Rolling circle DNA replication by extracts of herpes simplex virus type 1-infected human cells.
... of herpes simplex virus type 1 (HSV-1) circularizes upon the infection of susceptible cells and replicates predominantly by a rolling circle mechanism (1, 4, ... See full document
5
Viral DNA synthesis in cells infected with temperature-sensitive mutants of herpes simplex virus type 1.
... and 10% vol/vol tryptose phosphate broth Difco on 314 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Temperature-sensitive mutants of herpes simplex virus type 1 repre[r] ... See full document
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Characterization of RNA synthesized in isolated nuclei of herpes simplex virus type 1-infected KB cells.
... Because little self-complementary RNA was Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Nuclei isolated from herpes simplex virus HSV-infected KB cells actively synth[r] ... See full document
5
Accumulation of herpes simplex virus type 1 RNAs of different kinetic classes in the cytoplasm of infected cells.
... 144 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest We have analyzed the accumulation of herpes simplex virus type 1 RNA of the immediate early IE; infected cell polype[r] ... See full document
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