[PDF] Top 20 Activation of Human T-Cell Leukemia Virus Type 1tax Gene Expression in Chronically Infected T Cells
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Activation of Human T-Cell Leukemia Virus Type 1tax Gene Expression in Chronically Infected T Cells
... cellular activation stimuli that may affect HTLV-1 gene expression, we have utilized a series of HTLV-1 chronically infected cell lines exhibiting differing levels of ex- ... See full document
7
Human T cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules
... the expression of various cellular genes through the NF-κB and AP-1 pathways ...A549 cells cocultured with MT-2 cells exhibited high transcriptional activity of NF-κB and AP-1, compared with control ... See full document
10
Transcriptional activation of the vascular cell adhesion molecule-1 gene in T lymphocytes expressing human T-cell leukemia virus type 1 Tax protein.
... of cells transfected with the F4 con- struct, no induction of CAT activity by Tax was observed, suggesting that the major Tax-responsive elements in the VCAM-1 promoter were found between 2 98 and 2 ...VCAM-1 ... See full document
9
Inhibition of constitutively active Jak Stat pathway suppresses cell growth of human T cell leukemia virus type 1 infected T cell lines and primary adult T cell leukemia cells
... the expression of IAP and Bcl-2 family members, which determine the response to apoptotic ...the expression of XIAP and survivin, which are Stat-regu- lated genes [25,26], but not that of Bcl-x L protein in ... See full document
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Human T-Cell Leukemia Virus Type 1 Tax Relieves Repression of Proliferating Cell Nuclear Antigen Gene Expression
... 293 cells together with the pRL-SV40 Renilla luciferase reporter plasmid and either pCMV-Tax or sheared salmon sperm ...between cells transfected with 2X ⌬ PIR or 2X ⌬ PDR and cells transfected with ... See full document
9
The role of cyclin D2 and p21/waf1 in human T cell leukemia virus type 1 infected cells
... their expression levels during the early stages of the G 1 phase, as shown in Figures 3B and ...HTLV-1 infected cells (C81) and uninfected T-cells (CEM) were examined along with NIH-3T3 ... See full document
17
Overgrowth of human synovial cells driven by the human T cell leukemia virus type I tax gene
... synovial cell clones (SCCs) from three HTLV-I carriers who demonstrated synovial overgrowth but were otherwise ...tax gene exhibited high levels of proliferative ...tax expression plasmid into SCCs ... See full document
9
Polymorphic Nature of Human T-Cell Leukemia Virus Type 1 Particle Cores as Revealed through Characterization of a Chronically Infected Cell Line
... into virus particles produced from MT-2 cells (25). Since the MT-2 cell line harbors eight provi- ruses, a number of which could produce aberrant Gag proteins (24), we wanted to study the structure ... See full document
13
Role of O-Glycosylation and Expression of CD43 and CD45 on the Surfaces of Effector T Cells in Human T Cell Leukemia Virus Type 1 Cell-to-Cell Infection
... reporter gene with the neomycin resistance gene from the pcDNA ...of gene expression, we ex- ploited the pGIPZ mir30-based lentiviral vector from Open ...CD45 expression. To reduce CD43 ... See full document
12
Transmission of Human T-Cell Leukemia Virus Type 1 to Mice
... spleen cells of the infected ...this virus replicates mainly by cell division rather than by viral gene expression leading to viral amplification like human ... See full document
6
Aberrant Activation of the Interleukin-2 Autocrine Loop through the Nuclear Factor of Activated T Cells by Nonleukemogenic Human T-Cell Leukemia Virus Type 2 but Not by Leukemogenic Type 1 Virus
... in infected peripheral blood mononuclear cells ...Tax2 expression plays a central role in immortalization of T cells and maintenance of persistent ...primary human T ... See full document
10
Human T-Cell Lymphotropic Virus Type 1 p12I Expression Increases Cytoplasmic Calcium To Enhance the Activation of Nuclear Factor of Activated T Cells
... NFAT activation mediated by both ...NFAT activation induced by ionomycin treatment. Jurkat T cells were transfected with increasing amounts of pcDNA-CRT plus 10 g of NFAT-Luc, and the NFAT ... See full document
9
Human T cell leukemia virus type I (HTLV I) infection and the onset of adult T cell leukemia (ATL)
... the virus replication due to nonsense muta- tions or impairment of viral gene functions, some become capable of replicating under different circumstances such as the presence of anti-HIV drugs and ... See full document
13
APOBEC3G targets human T cell leukemia virus type 1
... MT-2/Vif cells to block incorporation of endogenous APOBEC3G into HTLV-1 ...virions. Expression of Vif in MT-2 cells reduced the expression of APOBEC3G and its incorporation into ...MT-2 ... See full document
10
Clonal expansion of human T-cell leukemia virus type I-infected cells in asymptomatic and symptomatic carriers without malignancy.
... 1 T rich, a value that closely resembles the A 1 T con- tent of the human ...a human Alu repeat (HSALU1), P20-50 showed 93% (219 of 235) identity with the human b -satellite DNA ... See full document
6
Human T-Cell Leukemia Virus Type 2 Tax Mutants That Selectively Abrogate NFκB or CREB/ATF Activation Fail To Transform Primary Human T Cells
... The human T-cell leukemia virus types 1 and 2 (HTLV-1 and HTLV-2) are oncogenic retroviruses associated with hu- man T-cell malignancies and degenerative neurological ... See full document
8
Silencing of human T cell leukemia virus type I gene transcription by epigenetic mechanisms
... in T-cells ...to gene silencing than ...ATL cells while 5'-LTR is methylated in about half of ...(HBZ) gene is encoded by minus strand of provirus ...HBZ gene was transcribed in ... See full document
16
Constitutive phosphorylation and turnover of I kappa B alpha in human T-cell leukemia virus type I-infected and Tax-expressing T cells.
... ketone (TPCK), an inhibitor of serine proteases, stabilizes I k B a and inhibits NF- k B-binding activity (27). The recent observation that HTLV-I Tax interacts with the ankyrin repeat domain of the p105 precursor of I k ... See full document
6
Altered Expression of Tyrosine Kinases of the Src and Syk Families in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines
... All cell lines were maintained in RPMI with Glutamax supplemented with 10% fetal calf serum, penicillin, and streptomycin (Life Technologies, ...a cell line derived from peripheral blood from a patient with ... See full document
9
Costimulation of cytokine gene expression in T cells by the human T leukemia/lymphotropic virus type 1 trans activator Tax.
... cellular gene expression appears to be associated with the virus-encoded trans-activat- ing protein p40x, or Tax, and overexpression of Tax in unin- fected cells is sufficient for the ... See full document
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