[PDF] Top 20 Adaptation of a CCR5-Using, Primary Human Immunodeficiency Virus Type 1 Isolate for CD4-Independent Replication
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Adaptation of a CCR5-Using, Primary Human Immunodeficiency Virus Type 1 Isolate for CD4-Independent Replication
... observed CD4-independent CCR5 bind- ...with CD4 independence might alter the conformation of the V2 loop, thereby better exposing the chemokine receptor-binding ...with CCR5 that ... See full document
7
Increased CCR5 Affinity and Reduced CCR5/CD4 Dependence of a Neurovirulent Primary Human Immunodeficiency Virus Type 1 Isolate
... of CD4 expression on rhesus macrophages restrict infection by M-tropic HIV-1 or T-tropic SIV strains (8, ...of CD4 or CCR5 expressed on human microglia may restrict infection by certain ... See full document
16
Continued Utilization of CCR5 Coreceptor by a Newly Derived T-Cell Line-Adapted Isolate of Human Immunodeficiency Virus Type 1
... of human immunodeficiency virus ...upon adaptation of primary isolates (PI) to growth in established T-cell ...be independent of neutralization ...TCLA virus that is ... See full document
6
Lentiviral Vectors Interfering with Virus-Induced CD4 Down-Modulation Potently Block Human Immunodeficiency Virus Type 1 Replication in Primary Lymphocytes
... during human immunodeficiency virus (HIV) infection. CD4 is required for entry of HIV into most permissive cells ...the CD4 re- ceptor from the surface of infected cells (reviewed in ... See full document
10
Differential CD4/CCR5 Utilization, gp120 Conformation, and Neutralization Sensitivity between Envelopes from a Microglia-Adapted Human Immunodeficiency Virus Type 1 and Its Parental Isolate
... use CD4 (26, 47, 64) and the seven-transmembrane- domain, G-protein-coupled chemokine receptor molecule CCR5 as coreceptors (4, 23, 28, 30, 32, 101, ...to CD4 induces conformational changes in gp120 ... See full document
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Determinants of Entry Cofactor Utilization and Tropism in a Dualtropic Human Immunodeficiency Virus Type 1 Primary Isolate
... not replication, while others enable both entry and productive infection, sug- gests that an Env function(s) in addition to cofactor-mediated entry is necessary for productive infection, possibly through ... See full document
7
Adaptation to persistent growth in the H9 cell line renders a primary isolate of human immunodeficiency virus type 1 sensitive to neutralization by vaccine sera.
... diverse primary isolates of human immunodeficiency virus type 1 (HIV-1) were examined and found to be refractory to neutralization by antisera to recombinant gp120 ... See full document
10
CD4-Independent Use of Rhesus CCR5 by Human Immunodeficiency Virus Type 2 Implicates an Electrostatic Interaction between the CCR5 N Terminus and the gp120 C4 Domain
... in human tissues and the more restricted expression of CD4, CD4-independent viruses would be expected to exhibit ex- panded tropism in ...However, primary CD4-independent ... See full document
13
CCR5 and CXCR4 Usage by Non-Clade B Human Immunodeficiency Virus Type 1 Primary Isolates
... studied CCR5 and CXCR4 usage by nine non- clade B, primary, full-length molecular clones previously de- scribed by Gao et ...used CCR5, whereas the other three exclusively used CXCR4 (Table ... See full document
6
Neutralization Sensitivity of Human Immunodeficiency Virus Type 1 Primary Isolates to Antibodies and CD4-Based Reagents Is Independent of Coreceptor Usage
... T-tropic primary HIV-1 isolates are differentially sensitive to neutral- ization by MAbs or CD4-based reagents, or that coreceptor usage (CCR5 versus CXCR4) was a significant variable affect- ... See full document
10
Genetic Subtype-Independent Inhibition of Human Immunodeficiency Virus Type 1 Replication by CC and CXC Chemokines
... HIV-1 replication is consistent with reports that this ligand has the lowest ability among MIP-1a, MIP-1b, and RANTES to activate signal transduction through CCR5 (3, ...for CCR5 in ... See full document
9
A Quantitative Affinity-Profiling System That Reveals Distinct CD4/CCR5 Usage Patterns among Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus Strains
... of human immunodeficiency virus (HIV) envelope for CD4 and CCR5 appears to be associated with aspects of R5 virus (virus using the CCR5 coreceptor) ...both ... See full document
11
Expanded Tropism of Primary Human Immunodeficiency Virus Type 1 R5 Strains to CD4+ T-Cell Lines Determined by the Capacity To Exploit Low Concentrations of CCR5
... Two primary R5 isolates out of ten also infected Molt4 and SupT1, providing evidence that viruses like the C3 variant do exist in ...several CCR5 ligands including 2D7 (a MAb specific for CCR5) ... See full document
6
Interaction with CD4 and Antibodies to CD4-Induced Epitopes of the Envelope gp120 from a Microglial Cell-Adapted Human Immunodeficiency Virus Type 1 Isolate
... leukemia virus (MLV) ...either human CD4 or CCR5 expression vectors or an empty vector as a negative ...80, using an SW41Ti rotor (Beckman, Palo Alto, CA) at 100,000 ⫻ g (29,000 rpm) ... See full document
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Inhibition of Human Immunodeficiency Virus Replication by a Dual CCR5/CXCR4 Antagonist
... of primary HIV-1 iso- lates, blood was collected from HIV-1-infected patients, isolated by Ficoll gra- dient, and mixed with 3-day-old phytohemagglutinin (PHA)-stimulated periph- eral blood ... See full document
11
Inhibition of Human Immunodeficiency Virus Type 1 Replication in Primary CD4+ T Lymphocytes, Monocytes, and Dendritic Cells by Cytotoxic T Lymphocytes
... other CD4-expressing cells are thought to be infected in ...the replication of monocyte-tropic (M-tropic, R5) strains of HIV-1 in ...of virus in vivo that may decay with slower kinetics than ... See full document
5
Effects of CCR5 and CD4 Cell Surface Concentrations on Infections by Macrophagetropic Isolates of Human Immunodeficiency Virus Type 1
... of primary T-cell-tropic HIV-1 are directly dependent on CD4 cell surface concentra- tions, whereas laboratory-adapted T-cell-tropic viruses can ef- ficiently infect cells independently of CD4 ... See full document
10
Cytokine Regulation of Human Immunodeficiency Virus Type 1 Entry and Replication in Human Monocytes/Macrophages through Modulation of CCR5 Expression
... of CCR5 in monocytes and macro- phages was measured by flow cytometry with the monoclonal antibody ...than 1% of fresh monocytes expressed CCR5 ...absent CCR5 expression in resting ... See full document
6
CXCR-4 Is Expressed by Primary Macrophages and Supports CCR5-Independent Infection by Dual-Tropic but Not T-Tropic Isolates of Human Immunodeficiency Virus Type 1
... which replication of even CCR5-dependent HIV-1 and sim- ian immunodeficiency virus strains may be restricted in mac- rophages (6, 23, 32), there may be conditions under which CXCR-4 ... See full document
6
Fcγ Receptor-Mediated Suppression of Human Immunodeficiency Virus Type 1 Replication in Primary Human Macrophages
... receptor CCR5 or CXCR4 (2), suggesting that Fc␥R-mediated HIV-1 suppression in MDM involves a postentry level of re- ...internalized virus to endosomal compartments and to ly- sosomes, resulting in ... See full document
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