[PDF] Top 20 Altered Gene Expression Associated with microRNA Binding Site Polymorphisms
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Altered Gene Expression Associated with microRNA Binding Site Polymorphisms
... tain binding sites for several different miRNAs, and quite often, there is more than one site for a specific ...single binding site may be reduced by the action of other ...miRNA ... See full document
25
Polymorphisms in microRNA target sites modulate risk of lymphoblastic and myeloid leukemias and affect microRNA binding
... Hardy-Weinberg equilibrium of the genotypes in the study groups was verified by the Chi-square test. The association between SNPs and leukemia risk was calcu- lated by estimating the odds ratio (OR) and its 95% ... See full document
13
Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes
... target site interactions may also involve local accessibility of the binding ...target site (Xiao et ...target site, and is likely to overestimate the number of true targets (Moxon et ... See full document
13
Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease
... by binding of the miRNA within the RISC to the complementary sequences in the 3 0 UTRs of target mRNAs (Figure 1) ...of gene expression acting on the mRNA at the post-transcriptional levels ...single ... See full document
18
Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes
... HIF1A gene and PDAC ...miR-199a binding site in HIF1A, could lead to differential regulation of HIF1A by ...HIF-1α expression on both mRNA and protein ...1α expression are significantly ... See full document
13
Impact of polymorphisms in microRNA biogenesis genes on colon cancer risk and microRNA expression levels: a population-based, case-control study
... corresponding gene showed that very few SNPs were predicted to have any ...be associated with altered colon cancer risk, rs2740348 (GEMIN4), which is in LD with rs2740349 ...miRNA expression ... See full document
14
GSK3B and MAPT polymorphisms are associated with grey matter and intracranial volume in healthy individuals
... tau gene (MAPT) codes for a protein that plays an integral role in stabilisation of microtubules and axonal transport in ...kinase-3b gene (GSK3B) codes for a serine/threonine kinase that phosphorylates ... See full document
7
MicroRNA-binding site polymorphisms in hematological malignancies
... were associated with increased ALL risk, while carriers of the variant allele of PML_rs9479 were at lower risk of ALL and ...miRNA binding was evaluated by luciferase reporter assay and confirmed for three ... See full document
6
Placental dysfunction is associated with altered microRNA expression in pregnant women with low folate status
... is associated with higher incidence of SGA infants (28% versus 13%, p < ...and altered placental hormones (pregnancy-associated plasma protein A, progesterone, and human placental ...a gene ... See full document
15
TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression
... AP-1 binding sites which are altered by causal variation, leading to differ- ences in gene ...cognate binding site in an intron of the SMAD3 gene has been shown to regulate ... See full document
18
MicroRNA binding site polymorphisms as biomarkers in cancer management and research
... nucleotide polymorphisms of transcripts may modulate the posttranscriptional regulation of gene expression by miRNAs and explain interindividual variability in cancer risk and in chemotherapy ... See full document
19
Prediction and Analysis of SARS-CoV-2-Targeting microRNA in Human Lung Epithelium
... non-conserved binding sites in the genomes of other prominent ...predicted binding sites, we found that only 28/128 and 23/128 had a predicted binding site (P < ...these binding ... See full document
13
An mRNA expression signature for prognostication in de novo acute myeloid leukemia patients with normal karyotype
... and Gene Set Enrichment Analysis (GSEA, Java program downloadable ...whole-genome expression pattern; ...the gene sets (biological functions) were downloaded from the IPA ... See full document
13
Cis regulatory somatic mutations and gene expression alteration in B cell lymphomas
... We expect our results to be an underestimate of the functional non-coding mutational landscape. Our approach relied on high-quality annotations of the cis- regulatory space, capitalizing on the availability of a large ... See full document
17
High expression of RUNX1 is associated with poorer outcomes in cytogenetically normal acute myeloid leukemia
... microarray expression data for LEF1 was in good agreement with quantitative real time PCR (qPCR) ...RUNX1 expression can be easily ...our gene/ microRNA expression data and cell ... See full document
12
Marek’s disease virus challenge induced immune related gene expression and chicken repeat 1 (CR1) methylation alterations in chickens
... governs gene transcription. In the present study, we found that expression of signal transducer and activa- tor of transcription 1 (STAT1) was upregulated at 10 days post infection (dpi) in MD susceptible ... See full document
10
Growth and the regulation of myotomal muscle mass in teleost fish
... phenotypes associated with the disruption or overexpression of individual ...the gene are responsible for the ‘double-muscling’ phenotype of Belgian Blue and Piedmontese cattle, Texel sheep and ‘bully’ ... See full document
12
rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk.
... menopause, number of pregnancies and family history 21 . Therefore, to exclude that an association of rs2735383 with breast cancer risk exists in a particular subgroup of individuals or breast cancer patients, we ... See full document
40
Mitogen-activated protein kinase binding protein 1 ( MAPKBP1 is an unfavorable prognostic biomarker in cytogenetically normal acute myeloid leukemia
... and gene mutations can induce NF-κB cell signalling pathway in AML[44], and small-molecule NF- κB pathway inhibitors are cytotoxic for AML blasts[45], and the SP1/NF-κB transactivation complex mediated SPARC ... See full document
11
A survey of motif discovery methods in an integrated framework
... understanding gene regulation, and as experimental identification and verification of such elements is challenging, much effort has been put into the development of computational ...of binding sites and ... See full document
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