[PDF] Top 20 Altered Substrate Specificity of Drug-Resistant Human Immunodeficiency Virus Type 1 Protease
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Altered Substrate Specificity of Drug-Resistant Human Immunodeficiency Virus Type 1 Protease
... various drug-resistant viruses produce differ- ent patterns of accumulated, partially processed polyproteins ...the protease can differentially affect cleavage site recognition and, by association, ... See full document
10
Structural Basis for Coevolution of a Human Immunodeficiency Virus Type 1 Nucleocapsid-p1 Cleavage Site with a V82A Drug-Resistant Mutation in Viral Protease
... Human immunodeficiency virus type 1 (HIV-1) matures af- ter the viral protease processes (35) the Gag and Pol polypro- teins at 10 substrate locations (3, ... See full document
9
Individual Contributions of Mutant Protease and Reverse Transcriptase to Viral Infectivity, Replication, and Protein Maturation of Antiretroviral Drug-Resistant Human Immunodeficiency Virus Type 1
... Genome stability of resistant isolates. The stability of viral Gag, PR, and RT sequences in the absence of drug pressure was assessed in PBMCs for up to 100 viral life cycles (20). Limited genetic evolution ... See full document
10
Sensitive Phenotypic Detection of Minor Drug Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptase Variants
... dual protease inhibitor-containing regimens in 481 patients on a failing regimen containing a protease inhibitor ...more protease inhibitors; approximately half of the subjects had prior experience ... See full document
9
Induction of T-Cell Immunity to Antiretroviral Drug-Resistant Human Immunodeficiency Virus Type 1
... I type A*0101/0205, B*0702/0801, Cw*0701/0702), a CD8 T-cell response was repeatedly de- tected against the pool containing resistant protease ... See full document
10
Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors.
... against human immunodeficiency virus type ...to protease inhibitors can develop and is attributed to the appearance of mutations in the protease ...the substrate analog ... See full document
8
In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects.
... Certain combinations of amino acid substitutions occur to- gether either more frequently or less frequently than expected if substitutions occur independently. It was surprising that untreated patients would harbor viral ... See full document
6
Effects of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors on Reverse Transcriptase Processing, Activity, and Drug Sensitivity
... inhibitor- resistant proteases from plasma virus were compared to iso- genic clones harboring the corresponding pretherapy protease ...of protease sequences were as previously described (20, ... See full document
5
Retracing the Evolutionary Pathways of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors: Virus Fitness in the Absence and in the Presence of Drug
... whom virus exposure to SQV is high due to more bioavailable formulations of the drug than in patients in whom SQV pressure is lower and in whom HIV-1 often displays L90M as a genetic marker of SQV ... See full document
8
Structural and Kinetic Analyses of the Protease from an Amprenavir-Resistant Human Immunodeficiency Virus Type 1 Mutant Rendered Resistant to Saquinavir and Resensitized to Amprenavir
... Recent drug regimens have had much success in the treatment of human immunodeficiency virus (HIV)- infected individuals; however, the incidence of resistance to such drugs has become a problem ... See full document
6
The Impact of Individual Human Immunodeficiency Virus Type 1 Protease Mutations on Drug Susceptibility Is Highly Influenced by Complex Interactions with the Background Protease Sequence
... for protease inhibitor (PI) resistance necessitates a better under- standing of the molecular basis of resistance ...clinical human immunodeficiency virus type 1 (HIV-1) ... See full document
9
Conditional human immunodeficiency virus type 1 protease mutants show no role for the viral protease early in virus replication.
... The human immunodeficiency virus type 1 protease plays a critical role in the proteolytic processing of precursor polyproteins during virion ...the protease early after ... See full document
5
Intracellular expression of human immunodeficiency virus type 1 (HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines.
... ventional drug-based antiviral therapies and td-PR-based gene therapy to treat emerging drug-resistant viral strains in ...systemic drug concentrations can be rapidly ...the virus can ... See full document
8
Monitoring Resistance to Human Immunodeficiency Virus Type 1 Protease Inhibitors by Pyrosequencing
... of resistant forms of the virus ...inadequate drug absorption, or drug resistance (18, ...of drug-resistant virus variants (9, ...HIV- 1-infected patients ... See full document
10
Structural Analysis of Human Immunodeficiency Virus Type 1 CRF01_AE Protease in Complex with the Substrate p1-p6
... the human immunodefi- ciency virus type 1 (HIV-1) has been classified into three groups, M (major), N (nonmajor), and O (other/outlier) ...HIV-1 protease is one of the ... See full document
5
Gag Determinants of Fitness and Drug Susceptibility in Protease Inhibitor-Resistant Human Immunodeficiency Virus Type 1
... under drug pressure ...of protease-resistant viruses, although the mech- anism remains unclear (12, ...and drug resistance, since mutant matrix and partial capsid regions can recover the RC of ... See full document
8
Human Immunodeficiency Virus Type 1 Protease Inhibitor Drug Resistant Mutants Give Discordant Results When Compared in Single Cycle and Multiple Cycle Fitness Assays
... whole virus versus recombinant virus, growth competitions versus parallel infections, direct measurement of a viral gene product versus a reporter gene, primary cells versus a cell line, and a single cycle ... See full document
9
Alteration of Substrate and Inhibitor Specificity of Feline Immunodeficiency Virus Protease
... the substrate-binding pocket are well ...the specificity of each protease. FIV protease has a distinct substrate specificity that differs from that of HIV-1 ... See full document
11
Molecular Basis for the Relative Substrate Specificity of Human Immunodeficiency Virus Type 1 and Feline Immunodeficiency Virus Proteases
... the substrate at a much greater rate than does FIV ...the substrate at a much higher rate than does HIV-1 ...several protease residues likely to dictate the observed specificity ... See full document
12
Replicative Fitness of Protease Inhibitor-Resistant Mutants of Human Immunodeficiency Virus Type 1
... other resistant HIV-1 mu- tants studied earlier with the same model (16, 21, 22, 27, ...mutant virus documented by the experimental data in the present study agrees with a prior study of the ... See full document
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