[PDF] Top 20 Alzheimer's disease Aß assemblies mediating rapid disruption of synaptic plasticity and memory
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Alzheimer's disease Aß assemblies mediating rapid disruption of synaptic plasticity and memory
... oligomers both in vitro and in vivo [107] whereas a Fab directed to the C-terminus of PrP C appeared to be in- active [67]. Since the alpha helix of PrP C does not overlap with the putative binding site of Aβ oligomers, ... See full document
10
Emotional enhancement of memory: how norepinephrine enables synaptic plasticity
... fear memory by regulating the suscep- tibility of cortico-amygdala and thalamo-amygdala syn- apses to LTP ...Could synaptic plasticity in the circuits underlying fear conditioning also be modulated ... See full document
9
Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition
... heterogeneous disease caused by multiple known and unknown ...manipulating memory-enhancing mechanisms may be beneficial to AD animal models irrespective of their individual etiology [18, 31], we examined ... See full document
10
Lithium rescues synaptic plasticity and memory in Down syndrome mice
... explicit memory, a feature that is replicated in relevant mouse models of the ...circuit plasticity and has been implicated in learning and ...hippocampal plasticity and behavioral performance in the ... See full document
15
Neuroprotective effect of β-asarone against Alzheimer’s disease: regulation of synaptic plasticity by increased expression of SYP and GluR1
... Notes: (A) Learning performance was analyzed by monitoring escape latency. Statistical analysis revealed a significant group effect (F=42.191, P=0.000) and significant interaction between factors (group × day) (F=3.151, ... See full document
9
Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats
... and memory and synaptic plasticity in the hippocampus of the immature nervous system in Wistar rats, and attempted to interpret the underlying ... See full document
9
Genes and signaling pathways involved in memory enhancement in mutant mice
... enhances memory in normal mice ...and memory in mice ...enhance memory in mice ...in synaptic plasticity and spatial memory in mice expressing familial Alzheimer's ... See full document
14
Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo
... Theories of how the brain stores memories have been made for decades, with early ideas including the suggestion that there is a specific brain area for memories and learning. Eventually, Hebb and Konorski suggested that ... See full document
79
From altered synaptic plasticity to atypical learning:a computational model of Down syndrome
... From altered synaptic plasticity to atypical learning: a computational model of Down syndrome.. Learning and memory rely on the adaptation of synaptic connections.[r] ... See full document
38
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease
... of synaptic plasticity and a key molecule in memory pro- cesses, the CREB protein (19, 20, ...of synaptic plasticity caused by overexpression of the APP and PS1 ... See full document
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Independent effects of white matter hyperintensities on cognitive, neuropsychiatric, and functional decline: a longitudinal investigation using the National Alzheimer’s Coordinating Center Uniform Data Set
... working memory and information processing speed (WAIS-R DSC), and learning and encoding (LM Imme- diate ...semantic memory, semantic fluency tasks have a significant executive function loading [79] that may ... See full document
13
Posterior atrophy predicts time to dementia in patients with amyloid-positive mild cognitive impairment
... For comparison of demographic and clinical variables be- tween groups with and without progression to dementia, we used the Pearson chi-squared test, Mann–Whitney test, or Student’s t test as appropriate. We assessed the ... See full document
9
Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer’s disease (DELCODE)
... German age, sex, and education-adjusted norms of the CERAD neuropsychological battery are available online (www.memoryclinic.ch). SCD was defined by the presence of subjectively reported decline in cognitive functioning ... See full document
10
Cognitive reserve and clinical progression in Alzheimer diseaseA paradoxical relationship
... Strengths of this study include our neuroimaging method to capture CR. 23 W scores are not based on lifestyle proxies, but derived from more direct measures that constitute the core of the concept (i.e., cognition and ... See full document
14
Dominantly Inherited Alzheimer Network: facilitating research and clinical trials
... Inherited Alzheimer Network (DIAN) is an international registry of individuals at risk for developing autosomal dominant Alzheimer ’ s disease ... See full document
7
Enhancement of Local Retionic Acid Signaling: A Pivotal Mechanism in Fluoxetine's Pleiotropic Actions
... effects. Synaptic plasticity including structural and functional processes in neurons due to environmental influences such as injury, stress and inflammation, is well known to be affected during MDD ... See full document
6
Mild cognitive impairment and deficits in instrumental activities of daily living: a systematic review
... Alzheimer’s disease; ADCS-ADL, Alzheimer’s Disease Cooperative Study/Activities of Daily Living Inventory; ADCS-MCI-ADL-18, 18-item Alzheimer’s Disease Cooperative Study/Activities of Daily Living ... See full document
20
Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer’s disease
... Elevated levels of CSF YKL-40 in early stages of AD have been demonstrated in two independent studies, but there are also contradictory data [28, 32, 40]. In our study, we confirmed that YKL-40 is elevated early in the ... See full document
8
Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort
... only), memory tests (DMS48 immediate recall and Free and Cued Selective Reminding Test sum of immediate total recall and sum of free and cued delayed recalls), and executive function ...all disease-specific ... See full document
13
Alzheimer’s Disease Assessment Scale–Cognitive subscale variants in mild cognitive impairment and mild Alzheimer’s disease: change over time and the effect of enrichment strategies
... For the past two decades, the 11-item Alzheimer’s Dis- ease Assessment Scale–Cognitive subscale (ADAS-Cog 11) has been a nearly ubiquitous measure of cognition in clinical trials of putative new therapies for Alzheimer’s ... See full document
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