[PDF] Top 20 Alzheimer's Disease: Synaptic Dysfunction and Aβ
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Alzheimer's Disease: Synaptic Dysfunction and Aβ
... (dodecamer) Aβ species were detected at an age that coincided with the first observed changes in spatial memory ...[86]. Aβ monomer, trimer and hexamer were seen at earlier time points and hence were not ... See full document
14
Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease
... ’ s disease (AD) is a devastating disease characterized by synaptic and neuronal loss in the ...induce synaptic loss in AD. A β -induced synaptic dysfunction is dependent ... See full document
12
Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer’s disease
... of Aβ on synaptic plasticity, we used several epitope-specific ...neutralize Aβ-mediated synaptotoxicity and reduce Aβ plaque load [3, 64, 83], thus leading to most anti-Aβ antibodies ... See full document
16
ALZHEIMER’S DISEASE: A REVIEW
... of Aβ. Furthermore, the development of Alzheimer disease in individuals with trisomy 21 has been related to a gene dosage effect with increased production of APP and subsequently ...familial ... See full document
9
Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer’s disease
... The study protocol was approved by the ethics commit- tee of the university clinic Erlangen-Nürnberg (number 3987), and all participants provided written informed consent. The patients were recruited in the memory clinic ... See full document
8
Dominantly Inherited Alzheimer Network: facilitating research and clinical trials
... CSF Aβ assays) as well as future ...National Alzheimer’ s Coordinating Center, the National Cell Repository for Alzheimer’s Disease, and the Alzheimer’ s Disease ... See full document
7
Mitochondrial β amyloid in Alzheimer's disease
... intracellular Aβ-binding protein and was first identified in 1997 using a yeast two-hybrid screen ...with Aβ (33). However the precise residues involved in the Aβ-ABAD interaction could not be ... See full document
11
Alzheimer’s Disease Assessment Scale–Cognitive subscale variants in mild cognitive impairment and mild Alzheimer’s disease: change over time and the effect of enrichment strategies
... In the context of this study, we also sought to deter- mine whether enrichment strategies could improve the sensitivity to change over time of these ADAS-Cog vari- ants. Since the introduction of enrichment as part of ... See full document
13
Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease
... Alzheimer’s disease and Parkinson’s disease are two common neurodegenerative diseases of the elderly people that have devastating effects in terms of morbidity and ...the disease in either case is ... See full document
14
Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels
... Alzheimer’s disease (AD). Cerebrospinal fluid (CSF) levels of amyloid-beta (Aβ) and tau change before clin- ical symptoms of AD are ...the disease progresses, and tau levels ... See full document
9
Untangling the Tauopathy for Alzheimer’s disease and parkinsonism
... Although AD and PD are considered as diseases prevalent in the elderly, the initiation of neuron pathology associated with tauopathy in the AD, PD, and other tauopathy-associ- ated neurodegenerative diseases starts early ... See full document
11
Cognitive reserve and clinical progression in Alzheimer diseaseA paradoxical relationship
... (median 12 months), possibly because repeated cognitive testing is more challenging at clinically advanced stages. As cognitive changes may be harder to capture over shorter follow-up durations, this could have caused a ... See full document
14
Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer’s disease (DELCODE)
... Memory services are often approached by individuals who subjectively experience decline in cognitive func- tioning but perform within the age, sex, and education- adjusted normal limits on standard cognitive tests. In- ... See full document
10
Alzheimer’s in a dish – induced pluripotent stem cell based disease modeling
... pathology Aβ has been described to interfere with synaptic processes and mediate synaptic degener- ation and toxicity (reviewed in ...of synaptic function and ...of Aβ to healthy ... See full document
13
Baicalein improves behavioral dysfunction induced by Alzheimer’s disease in rats
... II: disease control treated with AlCl 3 to induce the mimicking AD for 4 successive weeks (SW); Group III: normal control group treated with baicalein (5 mg/kg) for 2 SW followed by combination of baicalein and ... See full document
8
The Evolution of Aβ Peptide Burden in the APP23 Transgenic Mice: Implications for Aβ Deposition in Alzheimer Disease
... The heterogeneity exhibited in almost every as- pect of AD patients has complicated attempts to de- fine risk factors and predict the course of the disease. Consideration of the incomplete analogy between AD and ... See full document
10
Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti Aβ antibody
... The Aβ peptide was coimmunoprecipitated from hippocampal extracts prepared from PDAPP trans- genic mice by an anti–ChT-1 antibody followed by Western blot analysis with bioti- nylated anti-Aβ antibodies ... See full document
9
The role of cerebral amyloid β accumulation in common forms of Alzheimer disease
... and Aβ generation ...of Aβ by stimulating α-secretase to yield a processing pattern that is indistinguishable from regulated cleavage modulated by PKC and MAPK/ERK ...brain Aβ accumulation ... See full document
10
Olfactory dysfunction in Alzheimer’s disease
... olfactory dysfunction caused by diseases. It is also unclear during which disease stage AD pathological changes are limited to the olfactory ...olfactory dysfunction and other biomarkers of AD remain ... See full document
7
Prevalence of preclinical Alzheimer diseaseComparison of current classification systems
... Among the strengths of this study are the representative population-based sample, the relatively high response rate for LP, and the comprehensive examinations conducted by trained psychiatric nurses. Some limitations ... See full document
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