[PDF] Top 20 Animal models of systemic sclerosis: their utility and limitations
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Animal models of systemic sclerosis: their utility and limitations
... and systemic nature of systemic sclerosis and the poor replicability of many of the models utilized in studies published to date, the issue arises as to whether more than one model should be ... See full document
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Animal models of obsessive–compulsive disorder: utility and limitations
... For animal models of OCD, this would imply demonstrating the involvement of the OFC, ACC, or basal ganglia, as well as the serotonergic, dopaminergic, and glutamatergic systems and ovarian hormones in the ... See full document
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Animal models and therapeutic molecular targets of cancer: utility and limitations
... cancer models are described that could be used for diagnosis, therapy, or ...weaknesses, utility, and significance during development of novel therapeutic drugs and imaging agents for clinical ... See full document
12
Brain in flames – animal models of psychosis: utility and limitations
... found in adult glia cells, although its function there is not yet known; this model provides a good tool to screen how these cells are affected by an aberrant DISC1 production. Other combinatorial strategies include the ... See full document
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Animal models of myasthenia gravis: utility and limitations
... As discussed so far, the EAMG model has been exten- sively used to analyze various aspects of MG pathology and experimental therapies. Nevertheless, there are limita- tions in using this animal model. For ... See full document
12
<p>Animal models of well-differentiated/dedifferentiated liposarcoma: utility and limitations</p>
... WDL/DDL show high expression of several RTKs, including DDR2, ERBB3, NTRK1, FGFR3, ROS1, MET, AXL, KIT, and IGFR. 37,47 This leads to high activation of downstream signaling primarily through the Mapk and PI3K/Akt/mTOR ... See full document
12
Animal models of β-hemoglobinopathies: utility and limitations
... opmental β -like globin gene switching is simpler in the mouse than in humans, occurring only once (Figure 1). This fact and the brief gestational period of the mouse (21 days) compared to human suggest that biological ... See full document
12
Animal models of contraception: utility and limitations
... Validated animal models are crucial for preclinical predic- tion of drug safety and efficacy that cannot be determined in ...murine models has enabled discovery of pathways in reproductive biology ... See full document
9
Animal models of asthma: utility and limitations
... ogy. Animal models have been developed to better understand these mechanisms and to evaluate both safety and efficacy of therapies before starting clinical ...experimental models of asthma, such as ... See full document
9
Rodent models of diabetic nephropathy: their utility and limitations
... However, animal models have limited utility for understand- ing the pathogenesis of advanced diabetic nephropathy, in part because there is no ideal model that exhibits all of the key histological ... See full document
12
Abnormal endothelial cell function in scleroderma and related conditions
... Scleroderma is a connective tissue disease characterised by the deposition of excess collagen in skin and internal organs predominantly affecting young women (Black & Stephens 1993). Although there are references to ... See full document
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Animal models of ulcerative colitis and their application in drug research
... If the drug candidate does not pertain to any specific pathway/process, chemically induced colitis mice may be a good approach. The advantage of using these methods, as compared with spontaneous models, is the ... See full document
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Animal models of ischemic stroke and their application in clinical research
... stroke models and discusses their strengths and ...one animal model is not feasible because ischemic stroke in humans is a heterogeneous disorder with a complex ...the models that most closely ... See full document
10
The benefits and limitations of animal models for translational research in cartilage repair
... The chosen model affects the analysis that can the car- ried out, both during the study and post euthanasia at the study end point, and also the results that can be ob- tained. In smaller animals, it is possible to do in ... See full document
12
Pressure and pain In Systemic sclerosis/Scleroderma - an evaluation of a simple intervention (PISCES): randomised controlled trial protocol
... with Systemic Sclerosis (SSc)/Scleroderma have been reported to be both common and ...with Systemic Sclerosis can be improved through the provision of a simple pressure-relieving ... See full document
8
Primary myocardial disease in scleroderma – a comprehensive review of the literature to inform the UK Systemic Sclerosis Study Group cardiac working group
... Cardiac involvement is reported in both disease subtypes although more frequently in dcSSc (see Table 3) [60-64]. In the study by Ferri et al, 23% of lcSSc and 32% of dcSSc (p=0.05) had cardiac involvement at diagnosis ... See full document
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Cartilage oligomeric matrix protein induced complement activation in systemic sclerosis
... Systemic sclerosis (SSc) is a multi-organ disease character- ized by fibrosis of the skin and internal organs as well as vasculopathy [1]. SSc is generally divided into two subsets based on the extent of ... See full document
8
Identification of new autoantibody specificities directed at proteins involved in the transforming growth factor β pathway in patients with systemic sclerosis
... Systemic sclerosis (SSc) is a connective tissue disorder characterised by excessive collagen deposition in the dermis and internal organs, vascular hyperreactivity and obliteration phenomena ... See full document
13
Pressure and pain In Systemic sclerosis/Scleroderma an evaluation of a simple intervention (PISCES): randomised controlled trial protocol
... with Systemic Sclerosis (SSc)/Scleroderma have been reported to be both common and ...with Systemic Sclerosis can be improved through the provision of a simple pressure-relieving ... See full document
8
Comprehensive comparison of three different animal models for systemic inflammation
... mid-grade systemic inflammatory condition was ...mid-grade systemic inflammation making acute lethality very un- likely, in none of the three animal sepsis models antibiotic therapy or fluid ... See full document
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