[PDF] Top 20 Antioxidant Effect of Epigallocatechin-3-Gallate in a Bleomycin-Induced Scleroderma Model

... In conclusion, we state that EGCG reduced the severity of fibrosis in an experimental animal model of SSc. The improved pathology occurred in association with lower concentrations of pro- fibrogenic factors, lipid ... See full document

... effects and require a long duration of administration. Thus, it is urgent to develop another drug that is effective and does not induce side effects. EGCG is a possible solution. The literature has indicated ... See full document

... EGCG induced apoptotic cell death at 5 µg/mL ...and induced apoptotic molecular signals such as Bax/ Bcl-2, Caspase, and cytochrome ...graft model of HuCC-T1 cells, EGCG was subcutaneously ... See full document

... protective effect of EGCG against NaF induced changes in plasma lipid peroxidation and antioxidant status such as Vitamin C , E, and reduced glutathione and In vitro free radical scavenging assays of ... See full document

... potent antioxidant activity. Epigallocatechin gallate (EGCG) is one of the four major green tea ...substance epigallocatechin gallate (EGCG) in the pure form on the mutagenicity ... See full document

... Studies showed that miR-126 could enhance the sensi- tivity of non-small-cell lung cancer to adriamycin and vincristine [21] and cervical cancer cells to bleomycin [22]. In our study, we found that overexpression ... See full document

... and epigallocatechin 3-gallate (EGCG), the main phenolic component of GT, have been shown to have antioxidant, anti-carcinogenic, anti-mutagenic and anti-inflammatory activities (Fujiki ... See full document

... hypothetical model for inter- action networks, the proteins identified were imported into the EMBL Search Tool for the Retrieval of Interact- ing Proteins (STRING) database ... See full document

... an antioxidant and anti-inflammatory DJHQWDJDLQVWȕDP\ORLGDJJUHJDWLRQLQKLSSRFDPSXV and in this way EGCG may have a neuroprotective ...its antioxidant property ... See full document

... Osteoarthritis (OA) is a multifactorial degenerative joint disease which involves articular cartilage matrix destruc- tion and for which there is no cure and no useful treat- ments to block disease progression. The ... See full document

... cancer [41]. EGCG has antioxidant activities and re- solved inflammation during BLM induced pulmonary fibrosis [42]. BLM is clinically used for cancer therapy [21]. BLM plays both central and coordinated ... See full document

... an antioxidant and anti-inflammatory agent [10] against β-amyloid aggregation in hippocampus and in this way EGCG may have a neuroprotective ...A induced hippocampal neuronal cell death in cultured ... See full document

... dietary antioxidant. Its ORAC value exceeds that of various antioxidant rich foods such as raw Kiwi, extra virgin olive oil, lemon juice, brewed black ... See full document

... In rheumatic diseases, loss of the intricate balance between bone formation and bone resorption activity leads to skeletal abnormalities that aff ect the quality of life [29]. In particular, three TNF family molecules – ... See full document

... after dosing, may not be sufficient to determine T max , given the fact that T max of rosuvastatin is typically between 2 and 4 hours after dosing. Another limitation is that we were only able to recruit 13 volunteers ... See full document

... Recent in vivo and in vitro studies suggest the protective role of EGCG against free radical-induced neuronal damage [14,15]. Studies have indicated that S100B, a member of the S100 protein family, is abundant in ... See full document

... Interestingly, recent studies have identified a novel link between iron and AD, associated with an enhancement of endogenous APP translation and subsequent Ab formation, via activation of an iron responsive element ... See full document

... Next, SH-SY5Y-CFP-DEVD-YFP cells were treated for 72 hours with EGCG-GNPs at different concentrations and cell viability was measured by MTS assay (Figure 8C). At the end of 72 hours of exposure, EGCG-GNPs decreased cell ... See full document

... 11 cells were fixed in Carnoy’s fixatives (glacial acetic acid/methanol, 1:3, v/v), washed thrice with Carnoy’s fixative at intervals of 10 min. The pellet was resuspended in fixative and dropped on chilled slides ... See full document

... The results of total phenolic, total tannin and total flavon- oid content assays are presented in Table 1. The total phenolic and total flavonoid content decreased and total tannins increased, with an increasing degree ... See full document