[PDF] Top 20 AR1 Is an Integral Part of the Adenovirus Type 2 E1A-CR3 Transactivation Domain
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AR1 Is an Integral Part of the Adenovirus Type 2 E1A-CR3 Transactivation Domain
... for AR1 at its nat- ural ...for AR1 when artificially juxtaposed to the CR3 domain (DˆX, ...major E1A phosphorylation site, serine 231 ...of AR1 in the context of a full-length ... See full document
6
The human papillomavirus type 16 E7 protein complements adenovirus type 5 E1A amino-terminus-dependent transactivation of adenovirus type 5 early genes and increases ATF and Oct-1 DNA binding activity.
... mutant E1A pro- teins, cells known to express HPV E7 were analyzed for per- missiveness for Ad5 E1A mutant ...small-deletion E1A mutant viruses, dl348, and the wild-type virus ...in E1A ... See full document
9
Comparison of E1A CR3-Dependent Transcriptional Activation across Six Different Human Adenovirus Subgroups
... for CR3 function. The region of Ad5 E1A spanning residues 139 to 204 (which includes CR3) is critical for acti- vating the transcription necessary for virus growth and is suf- ficient for potent ... See full document
11
Cellular GCN5 Is a Novel Regulator of Human Adenovirus E1A-Conserved Region 3 Transactivation
... in E1A that maps to the CR3 ...hAd5 E1A through residues 26 to 35 in its N terminus ...(243R) E1A ⌬26-35 failed to coimmunoprecipitate GCN5, al- though this mutant can still ... See full document
12
Transcriptional transactivation of parvovirus B19 promoters in nonpermissive human cells by adenovirus type 2.
... the adenovirus E1A protein is a prototype promiscuous tran- scriptional transactivator ...that E1A targets a promoter by interacting with the DNA-binding domain of cellular transcription ... See full document
6
Adenovirus E4 open reading frame 4 protein autoregulates E4 transcription by inhibiting E1A transactivation of the E4 promoter.
... Since E1A transactivation of several viral promoters has been suggested to work through an induced phosphorylation of cellular transcription factors (reviewed in reference 1), it seemed possible that the ... See full document
8
E1A 12S and 13S of the transformation-defective adenovirus type 12 strain CS-1 inactivate proteins of the RB family, permitting transactivation of the E2F-dependent promoter.
... of E1A, shown to be essential for a functional interaction of p130 and p105-RB with Ad5 ...CR2 domain [GST-13S-DCR2 (Ad12)], and the 13S protein of nononcogenic Ad2 [GST-13S (Ad2)] were expressed and ... See full document
11
Phosphorylation within the transactivation domain of adenovirus E1A protein by mitogen-activated protein kinase regulates expression of early region 4.
... human adenovirus type 5 (Ad5) has been shown to transactivate both viral and cellular genes (for reviews, see references 8, 20, and ...which E1A products enhance gene ...and 2 (CR1 and CR2) of ... See full document
9
Identification of a Second CtBP Binding Site in Adenovirus Type 5 E1A Conserved Region 3
... the CR3-GAL4 reporter when CtBP expression was reduced (or “negated” by excess exon 2) ...activation domain may seem somewhat counterintuitive, recent studies have suggested that the level of ... See full document
11
Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis.
... of E1A domains in p53-independent ...of E1A products involved in causing p53- independent cell death, p53-deficient mouse 10(1) cells were infected with Ad5 mutants which fail to express E1B and which ... See full document
9
The CR1 and CR3 domains of the adenovirus type 5 E1A proteins can independently mediate activation of ATF-2.
... that CR3-dependent activation of Gal4–ATF-2 requires the presence of Thr-69 and Thr-71, located in the N terminus of ...of E1A (32) and for the activation of ATF-2 by genotoxic agents ... See full document
8
The transactivation domain of adenovirus E1A interacts with the C terminus of human TAF(II)135.
... Significantly, CR3 mutant proteins which fail to bind one or more of these cellular transcription factors are also defec- tive in E1A transactivation (7, 23, ...with CR3 need to be elucidated, ... See full document
6
Coxsackievirus and Adenovirus Receptor Amino-Terminal Immunoglobulin V-Related Domain Binds Adenovirus Type 2 and Fiber Knob from Adenovirus Type 12
... IgV-related domain (D1) and an adjacent IgC2-related domain (D2) ...virus type 1 (16). In each of these cases, the receptor amino-terminal domain also is related to the IgV domain fold ... See full document
7
Mitogenic activity of the adenovirus type 12 E1A gene induced by hormones in rat cells.
... The variation may merely reflect differences in the amounts of EGF receptor in these clonal cell lines, but it is likely that some other cellular factors besides ElA proteins are require[r] ... See full document
9
Uncoating of adenovirus type 2.
... Within 1 h of infection, virions were converted into three subviral structures: i subviral structures in the cytoplasm with a density greater than virions but which qualitatively still c[r] ... See full document
10
Autoregulation of adenovirus E1A gene expression.
... The surprisingly early and intense level of ElA expression in Ad3-infected cells suggests a stronger level of positive regulation of the gene than that observed with the more familiar Ad[r] ... See full document
10
Differential requirement for adenovirus type 12 E1A gene products in oncogenic transformation.
... 4997-5007 0022-538X/90/104997-11$02.00/0 Copyright © 1990, American Society for Microbiology Differential Requirement for Adenovirus Type 12 ElA Gene Products in Oncogenic Transformation[r] ... See full document
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trans-dominant interference of type 5 adenovirus E1a mutants in cell transformation.
... A wild-type parent strain or homologous viruses containing mutations at other loci cannot complement trans-dominant interfering mutants 49; therefore, if inlO4 and dllO5 are trans domina[r] ... See full document
8
Transcription factors regulated by the adenovirus E1a gene
... Many of the mammalian general factors that form a complex on the TATA element have conserved equivalents in yeast. Conservation is seen in several subunits of the RNA polymerases. The gene for the large subunit of RNA ... See full document
155
Genetic dissection of the transactivating domain of the E1a 289R protein of adenovirus type 2.
... To measure their effects on the transcriptional activation of a series of target genes, the extent of transcription of all viral early genes and the endogenous hsp70 gene, whose expressi[r] ... See full document
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