[PDF] Top 20 Ascl1 is required for oligodendrocyte development in the spinal cord
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Ascl1 is required for oligodendrocyte development in the spinal cord
... the spinal cord, these specified OLPs express either Nkx2-2 or Olig2, thereby comprising two molecularly distinct populations at early stages (Lu et ...rodent spinal cord, myelin gene ... See full document
11
Oligodendrocyte development in the embryonic brain: the contribution of the plp lineage
... of oligodendrocyte development in vivo show striking similarities to those for neuronal subtypes, including the emergence from localized regions of the neural tube, the involvment of common signalling ... See full document
12
Ascl1 controls the number and distribution of astrocytes and oligodendrocytes in the gray matter and white matter of the spinal cord
... cell development. We find that the transcription factor Ascl1 (Mash1), which is best known for its role in neurogenesis, also functions in both astrocyte and oligodendrocyte lineages arising in the ... See full document
11
Oligodendrocyte development in the embryonic tuberal hypothalamus and the influence of Ascl1
... for Ascl1 in gliogen- esis in the tuberal ...and Ascl1-null mutants showed a marked reduction in ...the Ascl1 single mutant showed an increase in the Olig2+ and Sox10+ cells at both at ...that ... See full document
15
Ascl1 defines sequentially generated lineage restricted neuronal and oligodendrocyte precursor cells in the spinal cord
... that Ascl1 is required for efficient neuronal ...embryo. Ascl1 mutant cells identified at ...if Ascl1 was ...the Ascl1 null some cells were maintained in an aberrant progenitor state – ... See full document
9
Making sense out of spinal cord somatosensory development
... and ASCL1, have been shown to directly regulate genes that control terminal neuronal phenotypes in addition to their role in regulating the expression of HD TFs (Borromeo et ...transporters required for ... See full document
15
Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons
... of spinal cord interneuron neurotransmitter ...zebrafish spinal cord and that lmx1bb is expressed by both V0v cells and dI5 ...not required for neurotransmitter fate specification at ... See full document
21
What is the potential of oligodendrocyte progenitor cells to successfully treat human spinal cord injury?
... Whilst it is possible to criticise the extrapolation of ani- mal data to humans, particularly in the context of SCI [72], one must bear in mind that whilst small-animal mod- els may be flawed, they are still an important ... See full document
9
Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord
... dorsal spinal cord at these ...during spinal cord ...mouse development, despite the robust co-expression of Smad1, Smad5 and Smad8 in extra-embryonic tissues, loss of either Smad1 or ... See full document
10
Transcription factors Sox8 and Sox10 perform non equivalent roles during oligodendrocyte development despite functional redundancy
... terminal oligodendrocyte differentiation is permanently or transiently affected, in situ hybridization studies of myelin gene expression were continued in the postnatal spinal ...heterozygous spinal ... See full document
10
Notch activity is required to maintain floorplate identity and to control neurogenesis in the chick hindbrain and spinal cord
... preference of Ser1 for Notch2 over Notch1 (Shimizu et al ., 1999). The homozygous phenotypes of two distinct Notch2 mutants have been studied in the mouse – one a hypomorph that survives to birth (McCright et al ., ... See full document
10
Extracellular signal-regulated kinase (ERK) activation is required for itch sensation in the spinal cord
... the spinal cord 1 d after the last DNFB treatment, and intrathecal injection of U0126 did not affect itch re- sponse in DNFB-induced chronic itch in mice ...the development of new itch- relieving ... See full document
15
Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor α expression
... For the preparation of cryotome sections, genotyped, age-matched embryos were fixed in 4% paraformaldehyde, cryoprotected in 30% sucrose and embedded in OCT compound at –80°C. As previously described, 10 m sections ... See full document
10
Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord
... tube development has been shown, as loss of Gdf7 expression leads to a specific loss of DI1 interneurons (Lee et ...in development of dorsal cell phenotypes in the neural tube using conditional and classic ... See full document
11
Repression of the hindbrain developmental program by Cdx factors is required for the specification of the vertebrate spinal cord
... and spinal cord precursor cells are broadly distributed along the margin of the epiblast and are not yet committed to their fate (Woo and Fraser, 1995; Woo and Fraser, ...and spinal cord cells ... See full document
12
Region specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord
... is required to supply sufficient cholesterol to the rapidly dividing neuroepithelium before neural tube closure, possibly through the endocytosis of cholesterol- containing lipoprotein (Herz et ... See full document
11
Gsh2 is required for the repression of Ngn1 and specification of dorsal interneuron fate in the spinal cord
... In this study, we provide evidence that the Gsh class of homeodomain transcription factors are key components of the genetic program that specifies dI3 interneuron identity in the dorsal spinal cord (Fig. ... See full document
12
Bcl11a is required for neuronal morphogenesis and sensory circuit formation in dorsal spinal cord development
... Mice with a null mutation in Bcl11a show defects in lymphopoiesis and die shortly after birth (Liu et al., 2003b). To define functions of Bcl11a in neurons and to distinguish functions in presynaptic primary sensory ... See full document
11
Neural development and regeneration: it's all in your spinal cord
... of spinal cord development and repair in a number of model organisms, allow us to unravel the principles underlying formation of the spinal circuits and their connections to the ...all ... See full document
6
Quality of Life and Related Factors Among People With Spinal Cord Injuries in Tehran, Iran
... Spinal Cord Injury (SCI) is considered as one of the big- gest problems and catastrophic events related to the health of people (1, ...2). Spinal cord injuries are one the health problems of ... See full document
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