[PDF] Top 20 Aspirin in venous leg ulcer study (ASPiVLU): study protocol for a randomised controlled trial

... small, randomised, controlled trials (RCTs) suggest aspirin may be effective in speeding ulcer healing and may reduce the ulcer recurrence, although the quality of this evidence is ... See full document

... Research on novel treatments with cell-based therapy is currently in progress, with promising results from phase II and phase III trials investigating the use of allogenic cells, either applied topically or via injection ... See full document

... community ulcer clinics, hospital outpatient clinics or home visits and will not be required to attend any further visits for research ...All randomised participants will receive aspirin or placebo ... See full document

... a randomised, controlled, assessor-blinded, two-centre, feasibility trial with two parallel ...a venous leg ulcer will be randomly assigned to receive usual care (compression ... See full document

... health, venous vascular function and skin microvascular func- tion [14, 25, 26] and the fact that it will likely be better tolerated than high-intensity ... See full document

... with study capsules was assessed in two ...(300mg Aspirin/placebo per day) this ...with study capsules for each participant, the responses across all weeks following delivery of the capsules up to ... See full document

... all leg ulcers, with a lifetime prevalence of ...a venous ulcer is a continuous cycle of healing and tissue de- rangement that can persist for a long time, with sub- stantial morbidity and recurrence ... See full document

... inclusion criteria were a venous ulcer below the knee to the foot that was present for at least 3 months and ability to travel to the clinic. Patients were assessed by clinic coordinators using Doppler ... See full document

... Background: Venous leg ulcers are slow-healing wounds with a high recurrence rate of 70% and a 60% risk of becoming ...estimated leg ulcer prevalence in the general population is ...for ... See full document

... synthesising trial effectiveness data from VenUS IV with other relevant RCTs ’ data within a ...single trial with a group for each treatment included in the ... See full document

... Background: In the United Kingdom (UK), there is an extensive market for the class 'A' drug heroin. Many heroin users spend time in prison. People addicted to heroin often require prescribed medication when attempting to ... See full document

... The primary endpoint is the composite endpoint of selected pregnancy- and birth-related complications: PIH, GDM, CS and LGA. PIH and GDM are assessed during pregnancy; CS and LGA are determined at time of delivery (Fig. ... See full document

... This randomised controlled trial uses a high-reach, low-cost strategy, which can readily be translated into clinical practice in underserved and mi- nority ... See full document

... no randomised placebo-controlled trials of clotrimazole in pregnancy to reduce preterm ...A randomised controlled trial of clotrimazole is necessary to provide the best evidence of ... See full document

... the trial at vari- ous gestations, including the fact that both using and not using lactate measurement are both common strat- egies at RWH and are accepted as appropriate by senior clinical ...the trial ... See full document

... clustered randomised controlled superiority trial conducted across 12 large Maternity Units in ...the study is to follow up each Unit for at least 12-months after they have commenced their ... See full document

... Background: In the United Kingdom (UK), there is an extensive market for the class 'A' drug heroin. Many heroin users spend time in prison. People addicted to heroin often require prescribed medication when attempting to ... See full document

... one study evaluated the withdrawal severity of methadone and lofexidine [12], the rates of completion were not sufficient to detect a statistically significant difference between the two ...Detoxification ... See full document

... the trial in keeping with current recommended ...in randomised controlled ...largest trial of over 500 women used "need for an additional uterotonic agent" as the primary out- come ... See full document

... This trial seeks to provide evidence for such an alterna- tive in the form of probiotics, which may increase breastfeeding duration and potentially provide long-term health, cognitive and developmental benefits ... See full document